Abstract
Background/Aims: Peritonitis is one of the complications of peritoneal dialysis. We demonstrate the systemic and intraperitoneal anti-inflammatory action of sulodexide given systemically. Methods: Dialysis was performed in male Wistar rats with acute peritonitis induced by addition of endotoxin to the fluid. Sulodexide (10 mg/kg b.w.) was used acutely as supplement to the dialysis fluid or chronically, during 7 days preceding the study by intramuscular (IM) injection. Results: In rats given IM sulodexide the dialysate cell count was lower by 45% (p < 0.001) versus untreated rats with peritonitis. Dialysate elastase activity in IM sulodexide-treated rats was lower by 22% (p < 0.05) compared to peritonitis. In rats treated with IM sulodexide the increase of plasma tumor necrosis factor-α was reduced by 53% (p < 0.002). Pretreatment with IM sulodexide reduced transperitoneal loss of total protein and albumin during peritonitis by 26% (p < 0.002) and by 16% (p < 0.05), respectively. Conclusion: Sulodexide given systemically reduces the intraperitoneal and vascular inflammatory response during acute peritonitis in rats.
Original language | English (US) |
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Pages (from-to) | 510-514 |
Number of pages | 5 |
Journal | Blood Purification |
Volume | 25 |
Issue number | 5-6 |
DOIs | |
State | Published - Jan 2008 |
Externally published | Yes |
Keywords
- Inflammation
- Lipopolysaccharide
- Peritonitis
- Tumor necrosis factor-α
ASJC Scopus subject areas
- Hematology
- Nephrology