Anti-inflammatory effect of sulodexide during acute peritonitis in rats

Jacek Karoń, Alicja Połubinska, Artur A. Antoniewicz, Katarzyna Sumińska-Jasińska, Andrzej Brȩborowicz

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Background/Aims: Peritonitis is one of the complications of peritoneal dialysis. We demonstrate the systemic and intraperitoneal anti-inflammatory action of sulodexide given systemically. Methods: Dialysis was performed in male Wistar rats with acute peritonitis induced by addition of endotoxin to the fluid. Sulodexide (10 mg/kg b.w.) was used acutely as supplement to the dialysis fluid or chronically, during 7 days preceding the study by intramuscular (IM) injection. Results: In rats given IM sulodexide the dialysate cell count was lower by 45% (p <0.001) versus untreated rats with peritonitis. Dialysate elastase activity in IM sulodexide-treated rats was lower by 22% (p <0.05) compared to peritonitis. In rats treated with IM sulodexide the increase of plasma tumor necrosis factor-α was reduced by 53% (p <0.002). Pretreatment with IM sulodexide reduced transperitoneal loss of total protein and albumin during peritonitis by 26% (p <0.002) and by 16% (p <0.05), respectively. Conclusion: Sulodexide given systemically reduces the intraperitoneal and vascular inflammatory response during acute peritonitis in rats.

Original languageEnglish (US)
Pages (from-to)510-514
Number of pages5
JournalBlood Purification
Volume25
Issue number5-6
DOIs
StatePublished - Jan 2008
Externally publishedYes

Fingerprint

Peritonitis
Anti-Inflammatory Agents
Dialysis Solutions
Dialysis
Pancreatic Elastase
Intramuscular Injections
Peritoneal Dialysis
glucuronyl glucosamine glycan sulfate
Endotoxins
Blood Vessels
Wistar Rats
Albumins
Tumor Necrosis Factor-alpha
Cell Count
Proteins

Keywords

  • Inflammation
  • Lipopolysaccharide
  • Peritonitis
  • Tumor necrosis factor-α

ASJC Scopus subject areas

  • Hematology
  • Nephrology

Cite this

Karoń, J., Połubinska, A., Antoniewicz, A. A., Sumińska-Jasińska, K., & Brȩborowicz, A. (2008). Anti-inflammatory effect of sulodexide during acute peritonitis in rats. Blood Purification, 25(5-6), 510-514. https://doi.org/10.1159/000113011

Anti-inflammatory effect of sulodexide during acute peritonitis in rats. / Karoń, Jacek; Połubinska, Alicja; Antoniewicz, Artur A.; Sumińska-Jasińska, Katarzyna; Brȩborowicz, Andrzej.

In: Blood Purification, Vol. 25, No. 5-6, 01.2008, p. 510-514.

Research output: Contribution to journalArticle

Karoń, J, Połubinska, A, Antoniewicz, AA, Sumińska-Jasińska, K & Brȩborowicz, A 2008, 'Anti-inflammatory effect of sulodexide during acute peritonitis in rats', Blood Purification, vol. 25, no. 5-6, pp. 510-514. https://doi.org/10.1159/000113011
Karoń J, Połubinska A, Antoniewicz AA, Sumińska-Jasińska K, Brȩborowicz A. Anti-inflammatory effect of sulodexide during acute peritonitis in rats. Blood Purification. 2008 Jan;25(5-6):510-514. https://doi.org/10.1159/000113011
Karoń, Jacek ; Połubinska, Alicja ; Antoniewicz, Artur A. ; Sumińska-Jasińska, Katarzyna ; Brȩborowicz, Andrzej. / Anti-inflammatory effect of sulodexide during acute peritonitis in rats. In: Blood Purification. 2008 ; Vol. 25, No. 5-6. pp. 510-514.
@article{4c266ec4808d4b53ad7311628bf66612,
title = "Anti-inflammatory effect of sulodexide during acute peritonitis in rats",
abstract = "Background/Aims: Peritonitis is one of the complications of peritoneal dialysis. We demonstrate the systemic and intraperitoneal anti-inflammatory action of sulodexide given systemically. Methods: Dialysis was performed in male Wistar rats with acute peritonitis induced by addition of endotoxin to the fluid. Sulodexide (10 mg/kg b.w.) was used acutely as supplement to the dialysis fluid or chronically, during 7 days preceding the study by intramuscular (IM) injection. Results: In rats given IM sulodexide the dialysate cell count was lower by 45{\%} (p <0.001) versus untreated rats with peritonitis. Dialysate elastase activity in IM sulodexide-treated rats was lower by 22{\%} (p <0.05) compared to peritonitis. In rats treated with IM sulodexide the increase of plasma tumor necrosis factor-α was reduced by 53{\%} (p <0.002). Pretreatment with IM sulodexide reduced transperitoneal loss of total protein and albumin during peritonitis by 26{\%} (p <0.002) and by 16{\%} (p <0.05), respectively. Conclusion: Sulodexide given systemically reduces the intraperitoneal and vascular inflammatory response during acute peritonitis in rats.",
keywords = "Inflammation, Lipopolysaccharide, Peritonitis, Tumor necrosis factor-α",
author = "Jacek Karoń and Alicja Połubinska and Antoniewicz, {Artur A.} and Katarzyna Sumińska-Jasińska and Andrzej Brȩborowicz",
year = "2008",
month = "1",
doi = "10.1159/000113011",
language = "English (US)",
volume = "25",
pages = "510--514",
journal = "Blood Purification",
issn = "0253-5068",
publisher = "S. Karger AG",
number = "5-6",

}

TY - JOUR

T1 - Anti-inflammatory effect of sulodexide during acute peritonitis in rats

AU - Karoń, Jacek

AU - Połubinska, Alicja

AU - Antoniewicz, Artur A.

AU - Sumińska-Jasińska, Katarzyna

AU - Brȩborowicz, Andrzej

PY - 2008/1

Y1 - 2008/1

N2 - Background/Aims: Peritonitis is one of the complications of peritoneal dialysis. We demonstrate the systemic and intraperitoneal anti-inflammatory action of sulodexide given systemically. Methods: Dialysis was performed in male Wistar rats with acute peritonitis induced by addition of endotoxin to the fluid. Sulodexide (10 mg/kg b.w.) was used acutely as supplement to the dialysis fluid or chronically, during 7 days preceding the study by intramuscular (IM) injection. Results: In rats given IM sulodexide the dialysate cell count was lower by 45% (p <0.001) versus untreated rats with peritonitis. Dialysate elastase activity in IM sulodexide-treated rats was lower by 22% (p <0.05) compared to peritonitis. In rats treated with IM sulodexide the increase of plasma tumor necrosis factor-α was reduced by 53% (p <0.002). Pretreatment with IM sulodexide reduced transperitoneal loss of total protein and albumin during peritonitis by 26% (p <0.002) and by 16% (p <0.05), respectively. Conclusion: Sulodexide given systemically reduces the intraperitoneal and vascular inflammatory response during acute peritonitis in rats.

AB - Background/Aims: Peritonitis is one of the complications of peritoneal dialysis. We demonstrate the systemic and intraperitoneal anti-inflammatory action of sulodexide given systemically. Methods: Dialysis was performed in male Wistar rats with acute peritonitis induced by addition of endotoxin to the fluid. Sulodexide (10 mg/kg b.w.) was used acutely as supplement to the dialysis fluid or chronically, during 7 days preceding the study by intramuscular (IM) injection. Results: In rats given IM sulodexide the dialysate cell count was lower by 45% (p <0.001) versus untreated rats with peritonitis. Dialysate elastase activity in IM sulodexide-treated rats was lower by 22% (p <0.05) compared to peritonitis. In rats treated with IM sulodexide the increase of plasma tumor necrosis factor-α was reduced by 53% (p <0.002). Pretreatment with IM sulodexide reduced transperitoneal loss of total protein and albumin during peritonitis by 26% (p <0.002) and by 16% (p <0.05), respectively. Conclusion: Sulodexide given systemically reduces the intraperitoneal and vascular inflammatory response during acute peritonitis in rats.

KW - Inflammation

KW - Lipopolysaccharide

KW - Peritonitis

KW - Tumor necrosis factor-α

UR - http://www.scopus.com/inward/record.url?scp=38849097250&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=38849097250&partnerID=8YFLogxK

U2 - 10.1159/000113011

DO - 10.1159/000113011

M3 - Article

C2 - 18187942

AN - SCOPUS:38849097250

VL - 25

SP - 510

EP - 514

JO - Blood Purification

JF - Blood Purification

SN - 0253-5068

IS - 5-6

ER -