Anti-biofilm activity of garlic extract loaded nanoparticles

Vallerinteavide Mavelli Girish, HongYing Liang, Jennifer T. Aguilan, Joshua D. Nosanchuk, Joel M. Friedman, Parimala Nacharaju

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

The emergence and widespread distribution of multi-drug resistant bacteria are considered as a major public health concern. The inabilities to curb severe infections due to antibiotic resistance have increased healthcare costs as well as patient morbidity and mortality. Bacterial biofilms formed by drug-resistant bacteria add additional challenges to treatment. This study describes a solgel based nanoparticle system loaded with garlic extract (GE-np) that exhibits: i) slow and sustained release of garlic components; ii) stabilization of the active components; and iii) significant enhancement of antimicrobial and antibiofilm activity relative to the free garlic extract. Also, GE-np were efficient in penetrating and disrupting the well-established methicillin-resistant Staphylococcus aureus (MRSA) biofilms. Overall, the study suggests that GE-np might be a promising candidate for the treatment of chronic infections due to biofilm forming drug-resistant bacteria.

Original languageEnglish (US)
Article number102009
JournalNanomedicine: Nanotechnology, Biology, and Medicine
Volume20
DOIs
StatePublished - Aug 2019

Keywords

  • Antibacterial
  • Biofilm
  • Garlic extract
  • MRSA
  • Nanoparticles

ASJC Scopus subject areas

  • Bioengineering
  • Medicine (miscellaneous)
  • Molecular Medicine
  • Biomedical Engineering
  • Materials Science(all)
  • Pharmaceutical Science

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