Anthropometric factors and thyroid cancer risk by histological subtype

Pooled analysis of 22 prospective studies

Cari M. Kitahara, Marjorie L. McCullough, Silvia Franceschi, Sabina Rinaldi, Alicja Wolk, Gila Neta, Hans Olov Adami, Kristin Anderson, Gabriella Andreotti, Laura E. Beane Freeman, Leslie Bernstein, Julie E. Buring, Francoise Clavel-Chapelon, Lisa A. De Roo, Yu Tang Gao, J. Michael Gaziano, Graham G. Giles, Niclas Håkansson, Pamela L. Horn-Ross, Vicki A. Kirsh & 24 others Martha S. Linet, Robert J. Macinnis, Nicola Orsini, Yikyung Park, Alpa V. Patel, Mark P. Purdue, Elio Riboli, Kimberly Robien, Thomas E. Rohan, Dale P. Sandler, Catherine Schairer, Arthur B. Schneider, Howard D. Sesso, Xiao Ou Shu, Pramil N. Singh, Piet A. Van Den Brandt, Elizabeth Ward, Elisabete Weiderpass, Emily White, Yong Bing Xiang, Anne Zeleniuch-Jacquotte, Wei Zheng, Patricia Hartge, Amy Berrington De González

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Background: Greater height and body mass index (BMI) have been associated with an increased risk of thyroid cancer, particularly papillary carcinoma, the most common and least aggressive subtype. Few studies have evaluated these associations in relation to other, more aggressive histologic types or thyroid cancer-specific mortality. Methods: This large pooled analysis of 22 prospective studies (833,176 men and 1,260,871 women) investigated thyroid cancer incidence associated with greater height, BMI at baseline and young adulthood, and adulthood BMI gain (difference between young-adult and baseline BMI), overall and separately by sex and histological subtype using multivariable Cox proportional hazards regression models. Associations with thyroid cancer mortality were investigated in a subset of cohorts (578,922 men and 774,373 women) that contributed cause of death information. Results: During follow-up, 2996 incident thyroid cancers and 104 thyroid cancer deaths were identified. All anthropometric factors were positively associated with thyroid cancer incidence: hazard ratios (HR) [confidence intervals (CIs)] for height (per 5 cm) = 1.07 [1.04-1.10], BMI (per 5 kg/m2) = 1.06 [1.02-1.10], waist circumference (per 5 cm) = 1.03 [1.01-1.05], young-adult BMI (per 5 kg/m2) = 1.13 [1.02-1.25], and adulthood BMI gain (per 5 kg/m2) = 1.07 [1.00-1.15]. Associations for baseline BMI and waist circumference were attenuated after mutual adjustment. Baseline BMI was more strongly associated with risk in men compared with women (p = 0.04). Positive associations were observed for papillary, follicular, and anaplastic, but not medullary, thyroid carcinomas. Similar, but stronger, associations were observed for thyroid cancer mortality. Conclusion: The results suggest that greater height and excess adiposity throughout adulthood are associated with higher incidence of most major types of thyroid cancer, including the least common but most aggressive form, anaplastic carcinoma, and higher thyroid cancer mortality. Potential underlying biological mechanisms should be explored in future studies.

Original languageEnglish (US)
Pages (from-to)306-318
Number of pages13
JournalThyroid
Volume26
Issue number2
DOIs
StatePublished - Feb 1 2016

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Thyroid Neoplasms
Prospective Studies
Body Mass Index
Mortality
Waist Circumference
Young Adult
Incidence
Papillary Carcinoma
Adiposity
Proportional Hazards Models
Cause of Death
Confidence Intervals
Carcinoma

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Kitahara, C. M., McCullough, M. L., Franceschi, S., Rinaldi, S., Wolk, A., Neta, G., ... De González, A. B. (2016). Anthropometric factors and thyroid cancer risk by histological subtype: Pooled analysis of 22 prospective studies. Thyroid, 26(2), 306-318. https://doi.org/10.1089/thy.2015.0319

Anthropometric factors and thyroid cancer risk by histological subtype : Pooled analysis of 22 prospective studies. / Kitahara, Cari M.; McCullough, Marjorie L.; Franceschi, Silvia; Rinaldi, Sabina; Wolk, Alicja; Neta, Gila; Olov Adami, Hans; Anderson, Kristin; Andreotti, Gabriella; Beane Freeman, Laura E.; Bernstein, Leslie; Buring, Julie E.; Clavel-Chapelon, Francoise; De Roo, Lisa A.; Gao, Yu Tang; Gaziano, J. Michael; Giles, Graham G.; Håkansson, Niclas; Horn-Ross, Pamela L.; Kirsh, Vicki A.; Linet, Martha S.; Macinnis, Robert J.; Orsini, Nicola; Park, Yikyung; Patel, Alpa V.; Purdue, Mark P.; Riboli, Elio; Robien, Kimberly; Rohan, Thomas E.; Sandler, Dale P.; Schairer, Catherine; Schneider, Arthur B.; Sesso, Howard D.; Shu, Xiao Ou; Singh, Pramil N.; Van Den Brandt, Piet A.; Ward, Elizabeth; Weiderpass, Elisabete; White, Emily; Xiang, Yong Bing; Zeleniuch-Jacquotte, Anne; Zheng, Wei; Hartge, Patricia; De González, Amy Berrington.

In: Thyroid, Vol. 26, No. 2, 01.02.2016, p. 306-318.

Research output: Contribution to journalArticle

Kitahara, CM, McCullough, ML, Franceschi, S, Rinaldi, S, Wolk, A, Neta, G, Olov Adami, H, Anderson, K, Andreotti, G, Beane Freeman, LE, Bernstein, L, Buring, JE, Clavel-Chapelon, F, De Roo, LA, Gao, YT, Gaziano, JM, Giles, GG, Håkansson, N, Horn-Ross, PL, Kirsh, VA, Linet, MS, Macinnis, RJ, Orsini, N, Park, Y, Patel, AV, Purdue, MP, Riboli, E, Robien, K, Rohan, TE, Sandler, DP, Schairer, C, Schneider, AB, Sesso, HD, Shu, XO, Singh, PN, Van Den Brandt, PA, Ward, E, Weiderpass, E, White, E, Xiang, YB, Zeleniuch-Jacquotte, A, Zheng, W, Hartge, P & De González, AB 2016, 'Anthropometric factors and thyroid cancer risk by histological subtype: Pooled analysis of 22 prospective studies', Thyroid, vol. 26, no. 2, pp. 306-318. https://doi.org/10.1089/thy.2015.0319
Kitahara CM, McCullough ML, Franceschi S, Rinaldi S, Wolk A, Neta G et al. Anthropometric factors and thyroid cancer risk by histological subtype: Pooled analysis of 22 prospective studies. Thyroid. 2016 Feb 1;26(2):306-318. https://doi.org/10.1089/thy.2015.0319
Kitahara, Cari M. ; McCullough, Marjorie L. ; Franceschi, Silvia ; Rinaldi, Sabina ; Wolk, Alicja ; Neta, Gila ; Olov Adami, Hans ; Anderson, Kristin ; Andreotti, Gabriella ; Beane Freeman, Laura E. ; Bernstein, Leslie ; Buring, Julie E. ; Clavel-Chapelon, Francoise ; De Roo, Lisa A. ; Gao, Yu Tang ; Gaziano, J. Michael ; Giles, Graham G. ; Håkansson, Niclas ; Horn-Ross, Pamela L. ; Kirsh, Vicki A. ; Linet, Martha S. ; Macinnis, Robert J. ; Orsini, Nicola ; Park, Yikyung ; Patel, Alpa V. ; Purdue, Mark P. ; Riboli, Elio ; Robien, Kimberly ; Rohan, Thomas E. ; Sandler, Dale P. ; Schairer, Catherine ; Schneider, Arthur B. ; Sesso, Howard D. ; Shu, Xiao Ou ; Singh, Pramil N. ; Van Den Brandt, Piet A. ; Ward, Elizabeth ; Weiderpass, Elisabete ; White, Emily ; Xiang, Yong Bing ; Zeleniuch-Jacquotte, Anne ; Zheng, Wei ; Hartge, Patricia ; De González, Amy Berrington. / Anthropometric factors and thyroid cancer risk by histological subtype : Pooled analysis of 22 prospective studies. In: Thyroid. 2016 ; Vol. 26, No. 2. pp. 306-318.
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TY - JOUR

T1 - Anthropometric factors and thyroid cancer risk by histological subtype

T2 - Pooled analysis of 22 prospective studies

AU - Kitahara, Cari M.

AU - McCullough, Marjorie L.

AU - Franceschi, Silvia

AU - Rinaldi, Sabina

AU - Wolk, Alicja

AU - Neta, Gila

AU - Olov Adami, Hans

AU - Anderson, Kristin

AU - Andreotti, Gabriella

AU - Beane Freeman, Laura E.

AU - Bernstein, Leslie

AU - Buring, Julie E.

AU - Clavel-Chapelon, Francoise

AU - De Roo, Lisa A.

AU - Gao, Yu Tang

AU - Gaziano, J. Michael

AU - Giles, Graham G.

AU - Håkansson, Niclas

AU - Horn-Ross, Pamela L.

AU - Kirsh, Vicki A.

AU - Linet, Martha S.

AU - Macinnis, Robert J.

AU - Orsini, Nicola

AU - Park, Yikyung

AU - Patel, Alpa V.

AU - Purdue, Mark P.

AU - Riboli, Elio

AU - Robien, Kimberly

AU - Rohan, Thomas E.

AU - Sandler, Dale P.

AU - Schairer, Catherine

AU - Schneider, Arthur B.

AU - Sesso, Howard D.

AU - Shu, Xiao Ou

AU - Singh, Pramil N.

AU - Van Den Brandt, Piet A.

AU - Ward, Elizabeth

AU - Weiderpass, Elisabete

AU - White, Emily

AU - Xiang, Yong Bing

AU - Zeleniuch-Jacquotte, Anne

AU - Zheng, Wei

AU - Hartge, Patricia

AU - De González, Amy Berrington

PY - 2016/2/1

Y1 - 2016/2/1

N2 - Background: Greater height and body mass index (BMI) have been associated with an increased risk of thyroid cancer, particularly papillary carcinoma, the most common and least aggressive subtype. Few studies have evaluated these associations in relation to other, more aggressive histologic types or thyroid cancer-specific mortality. Methods: This large pooled analysis of 22 prospective studies (833,176 men and 1,260,871 women) investigated thyroid cancer incidence associated with greater height, BMI at baseline and young adulthood, and adulthood BMI gain (difference between young-adult and baseline BMI), overall and separately by sex and histological subtype using multivariable Cox proportional hazards regression models. Associations with thyroid cancer mortality were investigated in a subset of cohorts (578,922 men and 774,373 women) that contributed cause of death information. Results: During follow-up, 2996 incident thyroid cancers and 104 thyroid cancer deaths were identified. All anthropometric factors were positively associated with thyroid cancer incidence: hazard ratios (HR) [confidence intervals (CIs)] for height (per 5 cm) = 1.07 [1.04-1.10], BMI (per 5 kg/m2) = 1.06 [1.02-1.10], waist circumference (per 5 cm) = 1.03 [1.01-1.05], young-adult BMI (per 5 kg/m2) = 1.13 [1.02-1.25], and adulthood BMI gain (per 5 kg/m2) = 1.07 [1.00-1.15]. Associations for baseline BMI and waist circumference were attenuated after mutual adjustment. Baseline BMI was more strongly associated with risk in men compared with women (p = 0.04). Positive associations were observed for papillary, follicular, and anaplastic, but not medullary, thyroid carcinomas. Similar, but stronger, associations were observed for thyroid cancer mortality. Conclusion: The results suggest that greater height and excess adiposity throughout adulthood are associated with higher incidence of most major types of thyroid cancer, including the least common but most aggressive form, anaplastic carcinoma, and higher thyroid cancer mortality. Potential underlying biological mechanisms should be explored in future studies.

AB - Background: Greater height and body mass index (BMI) have been associated with an increased risk of thyroid cancer, particularly papillary carcinoma, the most common and least aggressive subtype. Few studies have evaluated these associations in relation to other, more aggressive histologic types or thyroid cancer-specific mortality. Methods: This large pooled analysis of 22 prospective studies (833,176 men and 1,260,871 women) investigated thyroid cancer incidence associated with greater height, BMI at baseline and young adulthood, and adulthood BMI gain (difference between young-adult and baseline BMI), overall and separately by sex and histological subtype using multivariable Cox proportional hazards regression models. Associations with thyroid cancer mortality were investigated in a subset of cohorts (578,922 men and 774,373 women) that contributed cause of death information. Results: During follow-up, 2996 incident thyroid cancers and 104 thyroid cancer deaths were identified. All anthropometric factors were positively associated with thyroid cancer incidence: hazard ratios (HR) [confidence intervals (CIs)] for height (per 5 cm) = 1.07 [1.04-1.10], BMI (per 5 kg/m2) = 1.06 [1.02-1.10], waist circumference (per 5 cm) = 1.03 [1.01-1.05], young-adult BMI (per 5 kg/m2) = 1.13 [1.02-1.25], and adulthood BMI gain (per 5 kg/m2) = 1.07 [1.00-1.15]. Associations for baseline BMI and waist circumference were attenuated after mutual adjustment. Baseline BMI was more strongly associated with risk in men compared with women (p = 0.04). Positive associations were observed for papillary, follicular, and anaplastic, but not medullary, thyroid carcinomas. Similar, but stronger, associations were observed for thyroid cancer mortality. Conclusion: The results suggest that greater height and excess adiposity throughout adulthood are associated with higher incidence of most major types of thyroid cancer, including the least common but most aggressive form, anaplastic carcinoma, and higher thyroid cancer mortality. Potential underlying biological mechanisms should be explored in future studies.

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