Anthrax-associated shock

David L. Goldman; Arturo Casadevall

doi:10.2741/2988

Anthrax-associated shock

David L. Goldman, Arturo Casadevall

Research output: Contribution to journal › Review article › peer-review

17 Scopus citations

Abstract

Recent events have brought attention to the potential of Bacillus anthracis as an agent of bioterrorism. The shock like state of anthrax is invariably associated with high mortality, despite anti-microbial and supportive therapy. Multi-system dysfunction is typical, including: enhanced vascular permeability, hemorrhage and inflammation. Important questions concerning the pathophysiology of anthrax-associated shock remain unanswered, including the effects of B. anthracis infection on cardiac function. This review discusses the current state of knowledge regarding the pathophysiology of anthrax-associated shock.

Original language	English (US)
Pages (from-to)	4009-4014
Number of pages	6
Journal	Frontiers in Bioscience
Volume	13
Issue number	11
DOIs	https://doi.org/10.2741/2988
State	Published - 2008

Keywords

Anthrax
Bacillus anthracis
Edema toxin
Lethal toxin
Review
Shock

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology
General Immunology and Microbiology

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10.2741/2988

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title = "Anthrax-associated shock",

abstract = "Recent events have brought attention to the potential of Bacillus anthracis as an agent of bioterrorism. The shock like state of anthrax is invariably associated with high mortality, despite anti-microbial and supportive therapy. Multi-system dysfunction is typical, including: enhanced vascular permeability, hemorrhage and inflammation. Important questions concerning the pathophysiology of anthrax-associated shock remain unanswered, including the effects of B. anthracis infection on cardiac function. This review discusses the current state of knowledge regarding the pathophysiology of anthrax-associated shock.",

keywords = "Anthrax, Bacillus anthracis, Edema toxin, Lethal toxin, Review, Shock",

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AU - Casadevall, Arturo

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AB - Recent events have brought attention to the potential of Bacillus anthracis as an agent of bioterrorism. The shock like state of anthrax is invariably associated with high mortality, despite anti-microbial and supportive therapy. Multi-system dysfunction is typical, including: enhanced vascular permeability, hemorrhage and inflammation. Important questions concerning the pathophysiology of anthrax-associated shock remain unanswered, including the effects of B. anthracis infection on cardiac function. This review discusses the current state of knowledge regarding the pathophysiology of anthrax-associated shock.

KW - Anthrax

KW - Bacillus anthracis

KW - Edema toxin

KW - Lethal toxin

KW - Review

KW - Shock

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Anthrax-associated shock

Abstract

Keywords

ASJC Scopus subject areas

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