Anthrax-associated shock

David L. Goldman, Arturo Casadevall

Research output: Contribution to journalReview article

15 Scopus citations

Abstract

Recent events have brought attention to the potential of Bacillus anthracis as an agent of bioterrorism. The shock like state of anthrax is invariably associated with high mortality, despite anti-microbial and supportive therapy. Multi-system dysfunction is typical, including: enhanced vascular permeability, hemorrhage and inflammation. Important questions concerning the pathophysiology of anthrax-associated shock remain unanswered, including the effects of B. anthracis infection on cardiac function. This review discusses the current state of knowledge regarding the pathophysiology of anthrax-associated shock.

Original languageEnglish (US)
Pages (from-to)4009-4014
Number of pages6
JournalFrontiers in Bioscience
Volume13
Issue number11
DOIs
Publication statusPublished - May 5 2008

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Keywords

  • Anthrax
  • Bacillus anthracis
  • Edema toxin
  • Lethal toxin
  • Review
  • Shock

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

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