TY - JOUR
T1 - Anterograde transneuronal degeneration in the limbic system
T2 - Clinical-anatomic correlation
AU - Torch, William C.
AU - Hirano, Asao
AU - Solomon, Seymour
PY - 1977/12
Y1 - 1977/12
N2 - A 64-year-old man with diffuse atherosclerosis developed an organic mental syndrome, followed by hypothalamic symptoms. Autopsy showed an old large cystic infarct involving the left temporal lobe including the hippocampus, and atrophy of the ipsilateral fornix, mammillary body, hypothalamus, mammillothalamic tract, and the anterior thalamic nucleus. The clinical deterioration and pathologic findings may be explained by anterograde transneuronal degeneration within the limbic system following the infarction.
AB - A 64-year-old man with diffuse atherosclerosis developed an organic mental syndrome, followed by hypothalamic symptoms. Autopsy showed an old large cystic infarct involving the left temporal lobe including the hippocampus, and atrophy of the ipsilateral fornix, mammillary body, hypothalamus, mammillothalamic tract, and the anterior thalamic nucleus. The clinical deterioration and pathologic findings may be explained by anterograde transneuronal degeneration within the limbic system following the infarction.
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U2 - 10.1212/wnl.27.12.1157
DO - 10.1212/wnl.27.12.1157
M3 - Article
C2 - 412120
AN - SCOPUS:0017570911
SN - 0028-3878
VL - 27
SP - 1157
EP - 1163
JO - Neurology
JF - Neurology
IS - 12
ER -