Anterior horn cell degeneration and Bunina-type inclusions associated with dementia

Michael Noel Hart; Pasquale A. Cancilla; Stephen Frommes; Asao Hirano

doi:10.1007/BF00688069

Anterior horn cell degeneration and Bunina-type inclusions associated with dementia

Michael Noel Hart, Pasquale A. Cancilla, Stephen Frommes, Asao Hirano

Pathology

Research output: Contribution to journal › Article › peer-review

57 Scopus citations

Abstract

The ultrastructural features of Bunina type inclusions in the anterior horn cells of a patient dying of amyotrophic lateral sclerosis with dementia appear unique. The Bunina-type inclusions are electron dense aggregates containing, and surrounded by organelle-like membranes. These inclusions appear to be a special type of autophagic vacuole, possibly arising from altered mitochondria.

Original language	English (US)
Pages (from-to)	225-228
Number of pages	4
Journal	Acta neuropathologica
Volume	38
Issue number	3
DOIs	https://doi.org/10.1007/BF00688069
State	Published - Jan 1977

Keywords

Amyotrophic lateral sclerosis
Anterior horn cell degeneration
Autophagic vacuoles
Bunina inclusion
Mitochondrial alteration

ASJC Scopus subject areas

Pathology and Forensic Medicine
Clinical Neurology
Cellular and Molecular Neuroscience

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10.1007/BF00688069

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abstract = "The ultrastructural features of Bunina type inclusions in the anterior horn cells of a patient dying of amyotrophic lateral sclerosis with dementia appear unique. The Bunina-type inclusions are electron dense aggregates containing, and surrounded by organelle-like membranes. These inclusions appear to be a special type of autophagic vacuole, possibly arising from altered mitochondria.",

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AU - Hart, Michael Noel

AU - Cancilla, Pasquale A.

AU - Frommes, Stephen

AU - Hirano, Asao

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AB - The ultrastructural features of Bunina type inclusions in the anterior horn cells of a patient dying of amyotrophic lateral sclerosis with dementia appear unique. The Bunina-type inclusions are electron dense aggregates containing, and surrounded by organelle-like membranes. These inclusions appear to be a special type of autophagic vacuole, possibly arising from altered mitochondria.

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KW - Anterior horn cell degeneration

KW - Autophagic vacuoles

KW - Bunina inclusion

KW - Mitochondrial alteration

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Anterior horn cell degeneration and Bunina-type inclusions associated with dementia

Abstract

Keywords

ASJC Scopus subject areas

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