Anterior horn cell degeneration and Bunina-type inclusions associated with dementia

Michael Noel Hart, Pasquale A. Cancilla, Stephen Frommes, Asao Hirano

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

The ultrastructural features of Bunina type inclusions in the anterior horn cells of a patient dying of amyotrophic lateral sclerosis with dementia appear unique. The Bunina-type inclusions are electron dense aggregates containing, and surrounded by organelle-like membranes. These inclusions appear to be a special type of autophagic vacuole, possibly arising from altered mitochondria.

Original languageEnglish (US)
Pages (from-to)225-228
Number of pages4
JournalActa Neuropathologica
Volume38
Issue number3
DOIs
StatePublished - Jan 1977

Fingerprint

Anterior Horn Cells
Amyotrophic Lateral Sclerosis
Vacuoles
Organelles
Dementia
Mitochondria
Electrons
Membranes

Keywords

  • Amyotrophic lateral sclerosis
  • Anterior horn cell degeneration
  • Autophagic vacuoles
  • Bunina inclusion
  • Mitochondrial alteration

ASJC Scopus subject areas

  • Neuroscience(all)
  • Pathology and Forensic Medicine
  • Clinical Neurology

Cite this

Anterior horn cell degeneration and Bunina-type inclusions associated with dementia. / Hart, Michael Noel; Cancilla, Pasquale A.; Frommes, Stephen; Hirano, Asao.

In: Acta Neuropathologica, Vol. 38, No. 3, 01.1977, p. 225-228.

Research output: Contribution to journalArticle

Hart, Michael Noel ; Cancilla, Pasquale A. ; Frommes, Stephen ; Hirano, Asao. / Anterior horn cell degeneration and Bunina-type inclusions associated with dementia. In: Acta Neuropathologica. 1977 ; Vol. 38, No. 3. pp. 225-228.
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