Anterior eye development and ocular mesenchyme: New insights from mouse models and human diseases

Ales Cvekl, Ernst R. Tamm

Research output: Contribution to journalArticle

187 Citations (Scopus)

Abstract

During development of the anterior eye segment, cells that originate from the surface epithelium or the neuroepithelium need to interact with mesenchymal cells, which predominantly originate from the neural crest. Failures of proper interaction result in a complex of developmental disorders such Peters' anomaly, Axenfeld-Rieger's syndrome or aniridia. Here we review the role of transcription factors that have been identified to be involved in the coordination of anterior eye development. Among these factors is PAX6, which is active in both epithelial and mesenchymal cells during ocular development, albeit at different doses and times. We propose that PAX6 is a key element that synchronizes the complex interaction of cell types of different origin, which are all needed for proper morphogenesis of the anterior eye. We discuss several molecular mechanisms that might explain the effects of haploinsufficiency of PAX6 and other transcription factors, and the broad variation of the resulting phenotypes.

Original languageEnglish (US)
Pages (from-to)374-386
Number of pages13
JournalBioEssays
Volume26
Issue number4
DOIs
StatePublished - Apr 2004

Fingerprint

Mesoderm
human diseases
Transcription Factors
eyes
animal models
Aniridia
Anterior Eye Segment
Haploinsufficiency
transcription factors
Neural Crest
cells
Morphogenesis
Cell Communication
neural crest
Epithelium
Epithelial Cells
morphogenesis
Phenotype
epithelium
phenotype

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Biochemistry
  • Cell Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Developmental Biology
  • Agricultural and Biological Sciences (miscellaneous)
  • Plant Science

Cite this

Anterior eye development and ocular mesenchyme : New insights from mouse models and human diseases. / Cvekl, Ales; Tamm, Ernst R.

In: BioEssays, Vol. 26, No. 4, 04.2004, p. 374-386.

Research output: Contribution to journalArticle

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