Antepartum fetal surveillance tests during sickle cell crisis

Akolisa Anyaegbunam, Marie Ignace Gauthier Morel, Irwin R. Merkatz

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

A study was conducted to evaluate the characteristics of antepartum fetal assessment tests for women with sickle cell disease during crisis. A total of 24 women with 39 episodes of crisis after 34 weeks of pregnancy were studied. All subjects were evaluated with nonstress tests, biophysical profile score, and uterine and umbilical artery systolic/diastolic ratios during and after sickle cell crisis. Results revealed that the incidence of nonreactive nonstress tests was significantly higher during crisis compared with the period after crisis (58.9% vs 10.3%, p < 0.05). The frequency of biophysical profile score <8 was significantly higher during crisis compared with after crisis (33.3% vs 7.7%, p < 0.05). All subjects had an increase in uterine systolic/diastolic ratio during crisis. The average uterine systolic/diastolic ratio was 3.92 (range, 2.16 to 4.24) during crisis and 2.54 (range, 1.98 to 3.23) after crisis (p < 0.05). In contrast, there was no significant change in the mean umbilical systolic/diastolic ratios during and after crisis (2.58 and 2.62, respectively). We conclude that, although sickle cell disease crisis is associated with a higher incidence of abnormal biophysical test results, in most patients these results will revert to normal after crisis. The increase in uterine vascular resistance without a concordant increase in umbilical vascular resistance suggests that the transient effects of sickling during crisis may not compromise umbilical blood flow.

Original languageEnglish (US)
Pages (from-to)1081-1083
Number of pages3
JournalAmerican Journal of Obstetrics and Gynecology
Volume165
Issue number4 PART 1
DOIs
StatePublished - 1991

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Umbilicus
Sickle Cell Anemia
Vascular Resistance
Uterine Artery
Umbilical Arteries
Incidence
Pregnancy

Keywords

  • Doppler
  • nonstress test
  • Sickle cell crisis

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynecology

Cite this

Antepartum fetal surveillance tests during sickle cell crisis. / Anyaegbunam, Akolisa; Morel, Marie Ignace Gauthier; Merkatz, Irwin R.

In: American Journal of Obstetrics and Gynecology, Vol. 165, No. 4 PART 1, 1991, p. 1081-1083.

Research output: Contribution to journalArticle

Anyaegbunam, Akolisa ; Morel, Marie Ignace Gauthier ; Merkatz, Irwin R. / Antepartum fetal surveillance tests during sickle cell crisis. In: American Journal of Obstetrics and Gynecology. 1991 ; Vol. 165, No. 4 PART 1. pp. 1081-1083.
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