Antagonistic effect of atorvastatin on high fat diet induced survival during acute Chagas disease

Dazhi Zhao, Kezia Lizardo, Min-Hui Cui, Kamalakar Ambadipudi, Jose Lora, Linda A. Jelicks, Jyothi F. Nagajyothi

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Chagasic cardiomyopathy, which is seen in Chagas disease, is the most severe and life-threatening manifestation of infection by the kinetoplastid Trypanosoma cruzi. Adipose tissue and diet play a major role in maintaining lipid homeostasis and regulating cardiac pathogenesis during the development of Chagas cardiomyopathy. We have previously reported that T. cruzi has a high affinity for lipoproteins and that the invasion rate of this parasite increases in the presence of cholesterol, suggesting that drugs that inhibit cholesterol synthesis, such as statins, could affect infection and the development of Chagasic cardiomyopathy. The dual epidemic of diabetes and obesity in Latin America, the endemic regions for Chagas disease, has led to many patients in the endemic region of infection having hyperlipidemia that is being treated with statins such as atorvastatin. The current study was performed to examine mice fed on either regular or high fat diet for effects of atorvastatin on T. cruzi infection-induced myocarditis and to evaluate the effect of this treatment during infection on adipose tissue physiology and cardiac pathology. Atorvastatin was found to regulate lipolysis and cardiac lipidopathy during acute T. cruzi infection in mice and to enhance tissue parasite load, cardiac LDL levels, inflammation, and mortality in during acute infection. Overall, these data suggest that statins, such as atorvastatin, have deleterious effects during acute Chagas disease.

Original languageEnglish (US)
Pages (from-to)675-686
Number of pages12
JournalMicrobes and Infection
Volume18
Issue number11
DOIs
StatePublished - Nov 1 2016

Fingerprint

Chagas Disease
High Fat Diet
Acute Disease
Trypanosoma cruzi
Survival
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Infection
Cardiomyopathies
Adipose Tissue
Chagas Cardiomyopathy
Cholesterol
Parasite Load
Latin America
Lipolysis
Myocarditis
Atorvastatin Calcium
Hyperlipidemias
Lipoproteins
Parasites
Homeostasis

Keywords

  • Adipose tissue
  • Cardiomyopathy
  • Chagas disease
  • High fat diet
  • Lipidopathy
  • Metabolic disorder

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Infectious Diseases

Cite this

Antagonistic effect of atorvastatin on high fat diet induced survival during acute Chagas disease. / Zhao, Dazhi; Lizardo, Kezia; Cui, Min-Hui; Ambadipudi, Kamalakar; Lora, Jose; Jelicks, Linda A.; Nagajyothi, Jyothi F.

In: Microbes and Infection, Vol. 18, No. 11, 01.11.2016, p. 675-686.

Research output: Contribution to journalArticle

Zhao, D, Lizardo, K, Cui, M-H, Ambadipudi, K, Lora, J, Jelicks, LA & Nagajyothi, JF 2016, 'Antagonistic effect of atorvastatin on high fat diet induced survival during acute Chagas disease', Microbes and Infection, vol. 18, no. 11, pp. 675-686. https://doi.org/10.1016/j.micinf.2016.06.006
Zhao, Dazhi ; Lizardo, Kezia ; Cui, Min-Hui ; Ambadipudi, Kamalakar ; Lora, Jose ; Jelicks, Linda A. ; Nagajyothi, Jyothi F. / Antagonistic effect of atorvastatin on high fat diet induced survival during acute Chagas disease. In: Microbes and Infection. 2016 ; Vol. 18, No. 11. pp. 675-686.
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