ANOMALOUS EXCHANGE KINETICS OF PEPTIDE AMIDE PROTONS IN AQUEOUS SOLUTIONS

ERIC M. KRAUSS; DAVID COWBURN

doi:10.1111/j.1399-3011.1981.tb01966.x

ANOMALOUS EXCHANGE KINETICS OF PEPTIDE AMIDE PROTONS IN AQUEOUS SOLUTIONS

ERIC M. KRAUSS, DAVID COWBURN

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Reports concerning anomalous rates of exchange of some amides in oxytocin, alumichrome, and gramicidin S are reexamined through systematic analysis of the exchange data as a function of pH and primary structure. It is shown that such an analysis can provide useful information on secondary structure when the degree of hydrogen bonding to both the NH undergoing exchange and the neighboring carbonyl group are taken into consideration.

Original language	English (US)
Pages (from-to)	42-47
Number of pages	6
Journal	International Journal of Peptide and Protein Research
Volume	17
Issue number	1
DOIs	https://doi.org/10.1111/j.1399-3011.1981.tb01966.x
State	Published - Jan 1981
Externally published	Yes

Keywords

alumichrome
base catalysis of hydrogen exchange
effect of hydrogen‐bonding on peptide hydrogen exchange
gramicidin S
hydrogen exchange rates
oxytocin
peptide conformation

ASJC Scopus subject areas

Biochemistry

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10.1111/j.1399-3011.1981.tb01966.x

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title = "ANOMALOUS EXCHANGE KINETICS OF PEPTIDE AMIDE PROTONS IN AQUEOUS SOLUTIONS",

abstract = "Reports concerning anomalous rates of exchange of some amides in oxytocin, alumichrome, and gramicidin S are reexamined through systematic analysis of the exchange data as a function of pH and primary structure. It is shown that such an analysis can provide useful information on secondary structure when the degree of hydrogen bonding to both the NH undergoing exchange and the neighboring carbonyl group are taken into consideration.",

keywords = "alumichrome, base catalysis of hydrogen exchange, effect of hydrogen‐bonding on peptide hydrogen exchange, gramicidin S, hydrogen exchange rates, oxytocin, peptide conformation",

author = "KRAUSS, {ERIC M.} and DAVID COWBURN",

year = "1981",

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doi = "10.1111/j.1399-3011.1981.tb01966.x",

language = "English (US)",

volume = "17",

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journal = "International Journal of Peptide and Protein Research",

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AU - KRAUSS, ERIC M.

AU - COWBURN, DAVID

PY - 1981/1

Y1 - 1981/1

N2 - Reports concerning anomalous rates of exchange of some amides in oxytocin, alumichrome, and gramicidin S are reexamined through systematic analysis of the exchange data as a function of pH and primary structure. It is shown that such an analysis can provide useful information on secondary structure when the degree of hydrogen bonding to both the NH undergoing exchange and the neighboring carbonyl group are taken into consideration.

AB - Reports concerning anomalous rates of exchange of some amides in oxytocin, alumichrome, and gramicidin S are reexamined through systematic analysis of the exchange data as a function of pH and primary structure. It is shown that such an analysis can provide useful information on secondary structure when the degree of hydrogen bonding to both the NH undergoing exchange and the neighboring carbonyl group are taken into consideration.

KW - alumichrome

KW - base catalysis of hydrogen exchange

KW - effect of hydrogen‐bonding on peptide hydrogen exchange

KW - gramicidin S

KW - hydrogen exchange rates

KW - oxytocin

KW - peptide conformation

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AN - SCOPUS:0019491881

SN - 0367-8377

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JO - International Journal of Peptide and Protein Research

JF - International Journal of Peptide and Protein Research

IS - 1

ER -

ANOMALOUS EXCHANGE KINETICS OF PEPTIDE AMIDE PROTONS IN AQUEOUS SOLUTIONS

Abstract

Keywords

ASJC Scopus subject areas

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