ANOMALOUS EXCHANGE KINETICS OF PEPTIDE AMIDE PROTONS IN AQUEOUS SOLUTIONS

ERIC M. KRAUSS, DAVID COWBURN

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Reports concerning anomalous rates of exchange of some amides in oxytocin, alumichrome, and gramicidin S are reexamined through systematic analysis of the exchange data as a function of pH and primary structure. It is shown that such an analysis can provide useful information on secondary structure when the degree of hydrogen bonding to both the NH undergoing exchange and the neighboring carbonyl group are taken into consideration.

Original languageEnglish (US)
Pages (from-to)42-47
Number of pages6
JournalInternational Journal of Peptide and Protein Research
Volume17
Issue number1
DOIs
StatePublished - Jan 1981
Externally publishedYes

Keywords

  • alumichrome
  • base catalysis of hydrogen exchange
  • effect of hydrogen‐bonding on peptide hydrogen exchange
  • gramicidin S
  • hydrogen exchange rates
  • oxytocin
  • peptide conformation

ASJC Scopus subject areas

  • Biochemistry

Fingerprint Dive into the research topics of 'ANOMALOUS EXCHANGE KINETICS OF PEPTIDE AMIDE PROTONS IN AQUEOUS SOLUTIONS'. Together they form a unique fingerprint.

  • Cite this