Animal Models of Peritoneal Dialysis

Thirty Years of Our Own Experience

Krzysztof Pawlaczyk, Ewa Baum, Krzysztof Schwermer, Krzysztof Hoppe, Bengt Lindholm, Andrzej Breborowicz

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Experimental animal models improve our understanding of technical problems in peritoneal dialysis PD, and such studies contribute to solving crucial clinical problems. We established an acute and chronic PD model in nonuremic and uremic rats. We observed that kinetics of PD in rats change as the animals are aging, and this effect is due not only to an increasing peritoneal surface area, but also to changes in the permeability of the peritoneum. Changes of the peritoneal permeability seen during chronic PD in rats are comparable to results obtained in humans treated with PD. Effluent dialysate can be drained repeatedly to measure concentration of various bioactive molecules and to correlate the results with the peritoneal permeability. Additionally we can study in in vitro conditions properties of the effluent dialysate on cultured peritoneal mesothelial cells or fibroblasts. We can evaluate acute and chronic effect of various additives to the dialysis fluid on function and permeability of the peritoneum. Results from such study are even more relevant to the clinical scenario when experiments are performed in uremic rats. Our experimental animal PD model not only helps to understand the pathophysiology of PD but also can be used for testing biocompatibility of new PD fluids.

Original languageEnglish (US)
Article number261813
JournalBioMed Research International
Volume2015
DOIs
StatePublished - 2015
Externally publishedYes

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Dialysis
Peritoneal Dialysis
Rats
Permeability
Animals
Animal Models
Peritoneum
Dialysis Solutions
Effluents
Materials Testing
Fluids
Fibroblasts
Biocompatibility
Aging of materials
Molecules
Kinetics
Testing
Experiments

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

Cite this

Pawlaczyk, K., Baum, E., Schwermer, K., Hoppe, K., Lindholm, B., & Breborowicz, A. (2015). Animal Models of Peritoneal Dialysis: Thirty Years of Our Own Experience. BioMed Research International, 2015, [261813]. https://doi.org/10.1155/2015/261813

Animal Models of Peritoneal Dialysis : Thirty Years of Our Own Experience. / Pawlaczyk, Krzysztof; Baum, Ewa; Schwermer, Krzysztof; Hoppe, Krzysztof; Lindholm, Bengt; Breborowicz, Andrzej.

In: BioMed Research International, Vol. 2015, 261813, 2015.

Research output: Contribution to journalArticle

Pawlaczyk, K, Baum, E, Schwermer, K, Hoppe, K, Lindholm, B & Breborowicz, A 2015, 'Animal Models of Peritoneal Dialysis: Thirty Years of Our Own Experience', BioMed Research International, vol. 2015, 261813. https://doi.org/10.1155/2015/261813
Pawlaczyk K, Baum E, Schwermer K, Hoppe K, Lindholm B, Breborowicz A. Animal Models of Peritoneal Dialysis: Thirty Years of Our Own Experience. BioMed Research International. 2015;2015. 261813. https://doi.org/10.1155/2015/261813
Pawlaczyk, Krzysztof ; Baum, Ewa ; Schwermer, Krzysztof ; Hoppe, Krzysztof ; Lindholm, Bengt ; Breborowicz, Andrzej. / Animal Models of Peritoneal Dialysis : Thirty Years of Our Own Experience. In: BioMed Research International. 2015 ; Vol. 2015.
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