TY - JOUR
T1 - Animal models of closed-skull, repetitive mild traumatic brain injury
AU - Hoogenboom, Wouter S.
AU - Branch, Craig A.
AU - Lipton, Michael L.
N1 - Funding Information:
This research was supported by NIH/National Center for Advancing Translational Science (NCATS) Einstein-Montefiore CTSA Grant Number TL1TR001072; Burroughs Wellcome Foundation Grant (PUP program); NIH/National Institute of Neurological Disorders and Stroke R01 NS082432; and a grant from the Dana Foundation. The authors are thankful to Dr. Mark Wagshul of Albert Einstein College of Medicine and Dr. Philip V. Bayly of Washington University for their contribution in the discussion of the manuscript. WSH wrote the main manuscript text and prepared all tables and figures. MLL and CAB contributed to discussion, reviewed and edited the manuscript. The authors report no potential conflicts of interest. This research was supported by NIH/National Center for Advancing Translational Science (NCATS) Einstein-Montefiore CTSA Grant Number TL1TR001072; Burroughs Wellcome Foundation Grant (PUP program); NIH/National Institute of Neurological Disorders and Stroke R01 NS082432; and a grant from the Dana Foundation.
Funding Information:
This research was supported by NIH/National Center for Advancing Translational Science (NCATS) Einstein-Montefiore CTSA Grant Number TL1TR001072 ; Burroughs Wellcome Foundation Grant (PUP program); NIH/National Institute of Neurological Disorders and Stroke R01 NS082432 ; and a grant from the Dana Foundation .
Funding Information:
The authors are thankful to Dr. Mark Wagshul of Albert Einstein College of Medicine and Dr. Philip V. Bayly of Washington University for their contribution in the discussion of the manuscript. WSH wrote the main manuscript text and prepared all tables and figures. MLL and CAB contributed to discussion, reviewed and edited the manuscript. The authors report no potential conflicts of interest. This research was supported by NIH/National Center for Advancing Translational Science (NCATS) Einstein-Montefiore CTSA Grant Number TL1TR001072; Burroughs Wellcome Foundation Grant (PUP program); NIH/National Institute of Neurological Disorders and Stroke R01 NS082432; and a grant from the Dana Foundation.
Publisher Copyright:
© 2019 Elsevier Inc.
PY - 2019/6
Y1 - 2019/6
N2 - The underlying mechanisms that result in neurophysiological changes and cognitive sequelae in the context of repetitive mild traumatic brain injury (rmTBI) remain poorly understood. Animal models provide a unique opportunity to examine cellular and molecular responses using histological assessment, which can give important insights on the neurophysiological changes associated with the evolution of brain injury. To better understand the potential cumulative effects of multiple concussions, the focus of animal models is shifting from single to repetitive head impacts. With a growing body of literature on this subject, a review and discussion of current findings is valuable to better understand the neuropathology associated with rmTBI, to evaluate the current state of the field, and to guide future research efforts. Despite variability in experimental settings, existing animal models of rmTBI have contributed to our understanding of the underlying mechanisms following repeat concussion. However, how to reconcile the various impact methods remains one of the major challenges in the field today.
AB - The underlying mechanisms that result in neurophysiological changes and cognitive sequelae in the context of repetitive mild traumatic brain injury (rmTBI) remain poorly understood. Animal models provide a unique opportunity to examine cellular and molecular responses using histological assessment, which can give important insights on the neurophysiological changes associated with the evolution of brain injury. To better understand the potential cumulative effects of multiple concussions, the focus of animal models is shifting from single to repetitive head impacts. With a growing body of literature on this subject, a review and discussion of current findings is valuable to better understand the neuropathology associated with rmTBI, to evaluate the current state of the field, and to guide future research efforts. Despite variability in experimental settings, existing animal models of rmTBI have contributed to our understanding of the underlying mechanisms following repeat concussion. However, how to reconcile the various impact methods remains one of the major challenges in the field today.
KW - Animal research
KW - Concussion
KW - Mild traumatic brain injury
KW - Neuropathology
KW - Repetitive head impacts
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U2 - 10.1016/j.pharmthera.2019.02.016
DO - 10.1016/j.pharmthera.2019.02.016
M3 - Article
C2 - 30822463
AN - SCOPUS:85062356891
VL - 198
SP - 109
EP - 122
JO - Pharmacology and Therapeutics, Part A: Chemotherapy, Toxicology and
JF - Pharmacology and Therapeutics, Part A: Chemotherapy, Toxicology and
SN - 0163-7258
ER -