Abstract
The underlying mechanisms that result in neurophysiological changes and cognitive sequelae in the context of repetitive mild traumatic brain injury (rmTBI) remain poorly understood. Animal models provide a unique opportunity to examine cellular and molecular responses using histological assessment, which can give important insights on the neurophysiological changes associated with the evolution of brain injury. To better understand the potential cumulative effects of multiple concussions, the focus of animal models is shifting from single to repetitive head impacts. With a growing body of literature on this subject, a review and discussion of current findings is valuable to better understand the neuropathology associated with rmTBI, to evaluate the current state of the field, and to guide future research efforts. Despite variability in experimental settings, existing animal models of rmTBI have contributed to our understanding of the underlying mechanisms following repeat concussion. However, how to reconcile the various impact methods remains one of the major challenges in the field today.
| Original language | English (US) |
|---|---|
| Journal | Pharmacology and Therapeutics |
| DOIs | |
| State | Published - Jan 1 2019 |
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Keywords
- Animal research
- Concussion
- Mild traumatic brain injury
- Neuropathology
- Repetitive head impacts
ASJC Scopus subject areas
- Pharmacology
- Pharmacology (medical)
Cite this
Animal models of closed-skull, repetitive mild traumatic brain injury. / Hoogenboom, Wouter S.; Branch, Craig A.; Lipton, Michael L.
In: Pharmacology and Therapeutics, 01.01.2019.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Animal models of closed-skull, repetitive mild traumatic brain injury
AU - Hoogenboom, Wouter S.
AU - Branch, Craig A.
AU - Lipton, Michael L.
PY - 2019/1/1
Y1 - 2019/1/1
N2 - The underlying mechanisms that result in neurophysiological changes and cognitive sequelae in the context of repetitive mild traumatic brain injury (rmTBI) remain poorly understood. Animal models provide a unique opportunity to examine cellular and molecular responses using histological assessment, which can give important insights on the neurophysiological changes associated with the evolution of brain injury. To better understand the potential cumulative effects of multiple concussions, the focus of animal models is shifting from single to repetitive head impacts. With a growing body of literature on this subject, a review and discussion of current findings is valuable to better understand the neuropathology associated with rmTBI, to evaluate the current state of the field, and to guide future research efforts. Despite variability in experimental settings, existing animal models of rmTBI have contributed to our understanding of the underlying mechanisms following repeat concussion. However, how to reconcile the various impact methods remains one of the major challenges in the field today.
AB - The underlying mechanisms that result in neurophysiological changes and cognitive sequelae in the context of repetitive mild traumatic brain injury (rmTBI) remain poorly understood. Animal models provide a unique opportunity to examine cellular and molecular responses using histological assessment, which can give important insights on the neurophysiological changes associated with the evolution of brain injury. To better understand the potential cumulative effects of multiple concussions, the focus of animal models is shifting from single to repetitive head impacts. With a growing body of literature on this subject, a review and discussion of current findings is valuable to better understand the neuropathology associated with rmTBI, to evaluate the current state of the field, and to guide future research efforts. Despite variability in experimental settings, existing animal models of rmTBI have contributed to our understanding of the underlying mechanisms following repeat concussion. However, how to reconcile the various impact methods remains one of the major challenges in the field today.
KW - Animal research
KW - Concussion
KW - Mild traumatic brain injury
KW - Neuropathology
KW - Repetitive head impacts
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U2 - 10.1016/j.pharmthera.2019.02.016
DO - 10.1016/j.pharmthera.2019.02.016
M3 - Article
JO - Pharmacology and Therapeutics
JF - Pharmacology and Therapeutics
SN - 0163-7258
ER -