Abstract
Molecular mechanisms by which nonenveloped animal viruses penetrate a cellular membrane to invade the host cytoplasm remain less well characterized than those used by enveloped viruses. Mammalian reoviruses are useful agents for addressing this problem, especially in light of recent crystal structure determinations for the viral proteins and development of a new genetic tool with which to dissect the viral determinants of cell invasion. The roles of penetration protein μ1 and its protector protein σ3 are beginning to come into focus.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 374-382 |
| Number of pages | 9 |
| Journal | Trends in Microbiology |
| Volume | 11 |
| Issue number | 8 |
| DOIs | |
| State | Published - Aug 2003 |
| Externally published | Yes |
ASJC Scopus subject areas
- Microbiology
- Microbiology (medical)
- Infectious Diseases
- Virology
Fingerprint Dive into the research topics of 'Animal cell invasion by a large nonenveloped virus: Reovirus delivers the goods'. Together they form a unique fingerprint.
Cite this
Chandran, K., & Nibert, M. L. (2003). Animal cell invasion by a large nonenveloped virus: Reovirus delivers the goods. Trends in Microbiology, 11(8), 374-382. https://doi.org/10.1016/S0966-842X(03)00178-1