Abstract
Molecular mechanisms by which nonenveloped animal viruses penetrate a cellular membrane to invade the host cytoplasm remain less well characterized than those used by enveloped viruses. Mammalian reoviruses are useful agents for addressing this problem, especially in light of recent crystal structure determinations for the viral proteins and development of a new genetic tool with which to dissect the viral determinants of cell invasion. The roles of penetration protein μ1 and its protector protein σ3 are beginning to come into focus.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 374-382 |
| Number of pages | 9 |
| Journal | Trends in Microbiology |
| Volume | 11 |
| Issue number | 8 |
| DOIs | |
| State | Published - Aug 2003 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Infectious Diseases
- Microbiology
Cite this
Animal cell invasion by a large nonenveloped virus : Reovirus delivers the goods. / Chandran, Kartik; Nibert, Max L.
In: Trends in Microbiology, Vol. 11, No. 8, 08.2003, p. 374-382.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Animal cell invasion by a large nonenveloped virus
T2 - Reovirus delivers the goods
AU - Chandran, Kartik
AU - Nibert, Max L.
PY - 2003/8
Y1 - 2003/8
N2 - Molecular mechanisms by which nonenveloped animal viruses penetrate a cellular membrane to invade the host cytoplasm remain less well characterized than those used by enveloped viruses. Mammalian reoviruses are useful agents for addressing this problem, especially in light of recent crystal structure determinations for the viral proteins and development of a new genetic tool with which to dissect the viral determinants of cell invasion. The roles of penetration protein μ1 and its protector protein σ3 are beginning to come into focus.
AB - Molecular mechanisms by which nonenveloped animal viruses penetrate a cellular membrane to invade the host cytoplasm remain less well characterized than those used by enveloped viruses. Mammalian reoviruses are useful agents for addressing this problem, especially in light of recent crystal structure determinations for the viral proteins and development of a new genetic tool with which to dissect the viral determinants of cell invasion. The roles of penetration protein μ1 and its protector protein σ3 are beginning to come into focus.
UR - http://www.scopus.com/inward/record.url?scp=0141907317&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0141907317&partnerID=8YFLogxK
U2 - 10.1016/S0966-842X(03)00178-1
DO - 10.1016/S0966-842X(03)00178-1
M3 - Article
C2 - 12915095
AN - SCOPUS:0141907317
VL - 11
SP - 374
EP - 382
JO - Trends in Microbiology
JF - Trends in Microbiology
SN - 0966-842X
IS - 8
ER -