Animal cell invasion by a large nonenveloped virus: Reovirus delivers the goods

Kartik Chandran; Max L. Nibert

doi:10.1016/S0966-842X(03)00178-1

Animal cell invasion by a large nonenveloped virus: Reovirus delivers the goods

Kartik Chandran, Max L. Nibert

Research output: Contribution to journal › Review article › peer-review

66 Scopus citations

Abstract

Molecular mechanisms by which nonenveloped animal viruses penetrate a cellular membrane to invade the host cytoplasm remain less well characterized than those used by enveloped viruses. Mammalian reoviruses are useful agents for addressing this problem, especially in light of recent crystal structure determinations for the viral proteins and development of a new genetic tool with which to dissect the viral determinants of cell invasion. The roles of penetration protein μ1 and its protector protein σ3 are beginning to come into focus.

Original language	English (US)
Pages (from-to)	374-382
Number of pages	9
Journal	Trends in Microbiology
Volume	11
Issue number	8
DOIs	https://doi.org/10.1016/S0966-842X(03)00178-1
State	Published - Aug 2003
Externally published	Yes

ASJC Scopus subject areas

Microbiology
Microbiology (medical)
Infectious Diseases
Virology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0966-842X(03)00178-1

Cite this

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title = "Animal cell invasion by a large nonenveloped virus: Reovirus delivers the goods",

abstract = "Molecular mechanisms by which nonenveloped animal viruses penetrate a cellular membrane to invade the host cytoplasm remain less well characterized than those used by enveloped viruses. Mammalian reoviruses are useful agents for addressing this problem, especially in light of recent crystal structure determinations for the viral proteins and development of a new genetic tool with which to dissect the viral determinants of cell invasion. The roles of penetration protein μ1 and its protector protein σ3 are beginning to come into focus.",

author = "Kartik Chandran and Nibert, {Max L.}",

note = "Funding Information: We thank T.S. Baker, S.C. Harrison, T. Kirchhausen, J.K. Middleton, L.A. Schiff and J. Yin for helpful discussions. We also thank T.J. Broering, I. S. Kim, K.S. Myers, A.L. Odegard, J.S.L. Parker and other members of our laboratory for helpful discussions or critiques. We apologize to colleagues whose work may not have been cited due to length constraints. Work on reovirus invasion and mRNA synthesis is supported in our laboratory by United States Public Health Service grants AI46440 and AI47904 from the NIH. ",

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doi = "10.1016/S0966-842X(03)00178-1",

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AU - Nibert, Max L.

N1 - Funding Information: We thank T.S. Baker, S.C. Harrison, T. Kirchhausen, J.K. Middleton, L.A. Schiff and J. Yin for helpful discussions. We also thank T.J. Broering, I. S. Kim, K.S. Myers, A.L. Odegard, J.S.L. Parker and other members of our laboratory for helpful discussions or critiques. We apologize to colleagues whose work may not have been cited due to length constraints. Work on reovirus invasion and mRNA synthesis is supported in our laboratory by United States Public Health Service grants AI46440 and AI47904 from the NIH.

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N2 - Molecular mechanisms by which nonenveloped animal viruses penetrate a cellular membrane to invade the host cytoplasm remain less well characterized than those used by enveloped viruses. Mammalian reoviruses are useful agents for addressing this problem, especially in light of recent crystal structure determinations for the viral proteins and development of a new genetic tool with which to dissect the viral determinants of cell invasion. The roles of penetration protein μ1 and its protector protein σ3 are beginning to come into focus.

AB - Molecular mechanisms by which nonenveloped animal viruses penetrate a cellular membrane to invade the host cytoplasm remain less well characterized than those used by enveloped viruses. Mammalian reoviruses are useful agents for addressing this problem, especially in light of recent crystal structure determinations for the viral proteins and development of a new genetic tool with which to dissect the viral determinants of cell invasion. The roles of penetration protein μ1 and its protector protein σ3 are beginning to come into focus.

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Animal cell invasion by a large nonenveloped virus: Reovirus delivers the goods

Abstract

ASJC Scopus subject areas

UN SDGs

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