Animal cell invasion by a large nonenveloped virus: Reovirus delivers the goods

Kartik Chandran, Max L. Nibert

Research output: Contribution to journalReview article

59 Scopus citations

Abstract

Molecular mechanisms by which nonenveloped animal viruses penetrate a cellular membrane to invade the host cytoplasm remain less well characterized than those used by enveloped viruses. Mammalian reoviruses are useful agents for addressing this problem, especially in light of recent crystal structure determinations for the viral proteins and development of a new genetic tool with which to dissect the viral determinants of cell invasion. The roles of penetration protein μ1 and its protector protein σ3 are beginning to come into focus.

Original languageEnglish (US)
Pages (from-to)374-382
Number of pages9
JournalTrends in Microbiology
Volume11
Issue number8
DOIs
StatePublished - Aug 2003

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ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)
  • Infectious Diseases
  • Virology

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