Angiopoietin-like proteins: A comprehensive look

Gaetano Santulli

Research output: Contribution to journalShort survey

116 Scopus citations

Abstract

Angiopoietin-like proteins (ANGPTLs) are a family of proteins structurally similar to the angiopoietins. To date, eight ANGPTLs have been discovered, namely ANGPTL1 to ANGPTL8. Emerging evidence implies a key role for ANGPTLs in the regulation of a plethora of physiological and pathophysiological processes. Most of the ANGPTLs exhibit multibiological properties, including established functional roles in lipid and glucose metabolism, inflammation, hematopoiesis, and cancer. This report represents a systematic and updated appraisal of this class of proteins, focusing on the main features of each ANGPTL.

Original languageEnglish (US)
Article numberArticle 4
JournalFrontiers in Endocrinology
Volume5
Issue numberJAN
DOIs
StatePublished - Jan 1 2014

Keywords

  • Angiopoietin-like proteins
  • Angptl
  • Cancer
  • Glucose homeostasis
  • Hematopoietic stem cells
  • Inflammation
  • Insulin
  • Metabolism

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

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