Abstract
Angiopoietin-like proteins (ANGPTLs) are a family of proteins structurally similar to the angiopoietins. To date, eight ANGPTLs have been discovered, namely ANGPTL1 to ANGPTL8. Emerging evidence implies a key role for ANGPTLs in the regulation of a plethora of physiological and pathophysiological processes. Most of the ANGPTLs exhibit multibiological properties, including established functional roles in lipid and glucose metabolism, inflammation, hematopoiesis, and cancer. This report represents a systematic and updated appraisal of this class of proteins, focusing on the main features of each ANGPTL.
| Original language | English (US) |
|---|---|
| Article number | Article 4 |
| Journal | Frontiers in Endocrinology |
| Volume | 5 |
| Issue number | JAN |
| DOIs | |
| State | Published - 2014 |
| Externally published | Yes |
Keywords
- Angiopoietin-like proteins
- Angptl
- Cancer
- Glucose homeostasis
- Hematopoietic stem cells
- Inflammation
- Insulin
- Metabolism
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
