Angiogenesis and its modulation in the pathophysiology and treatment of endometrial carcinoma

Craig A. Mayr, June Yijuan Hou, Gary L. Goldberg, Dennis Yi Shin Kuo

Research output: Contribution to journalReview article

Abstract

Endometrial cancer is the most common gynecologic malignancy in women. When detected early, this disease has a relatively good prognosis. However, advanced stage disease is associated with a poor outcome. Current therapies for advanced endometrial cancer include surgery, chemotherapy, radiotherapy, and hormonal therapy. Responses to these modalities are variable, but rarely exceed 20%. Angiogenesis plays a critical role in both the normal and the pathologic physiology of the human endometrium. Like a wide array of other tumors, the formation of new blood vessels to feed an enlarging tumor mass occurs in endometrial cancer. This review focuses on the role of angiogenesis and its inhibition in the pathophysiology and treatment of endometrial cancer.

Original languageEnglish (US)
Pages (from-to)43-48
Number of pages6
JournalOncology Reviews
Volume5
Issue number1
DOIs
Publication statusPublished - Mar 1 2011

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Keywords

  • Angiogenesis
  • Antiangiogenesis therapy
  • Endometrial cancer
  • Endometrium

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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