Analysis of transcripts from 17p13.3 in medulloblastoma suggests ROX/MNT as a potential tumour suppressor gene

Ales Cvekl, Jiri Zavadil, Barbara K. Birshtein, Michael A. Grotzer, Ales Cvekl

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

Haploinsufficiency of the human 17p13.3 region is associated with 35% to 50% of medulloblastomas, indicating the presence of one or more tumour suppressor genes which have not yet been identified. Of 119 genes residing in this region, seven genes- 14-3-3ε (YWHAE), HIC-1, ROX/MNT (a helix-loop-helix transcription factor and member of the MYC/MAX superfamily), KIAA0399, UBE2G1 (ubiquitin ligase), ALOX15, and MINK - encode proteins with potential links to cancer. We investigated these genes and found significant levels of expression of ROX/MNT in adult human cerebellum, and in embryonic and postnatal mouse cerebellum. Six of 14 medulloblastomas showed a reduction of ROX/MNT expression, accompanied by a reduction of both UBE2G1 and 14-3-3ε in three tumours and a reduction of UBE2G1 in one tumour. Moreover, the relative expression of MYC to ROX/MNT was increased in 4 of the 14 medulloblastomas. Collectively, these data suggest that ROX/MNT should be considered a potential tumour suppressor gene in medulloblastoma.

Original languageEnglish (US)
Pages (from-to)2525-2532
Number of pages8
JournalEuropean Journal of Cancer
Volume40
Issue number16
DOIs
StatePublished - Nov 1 2004

Keywords

  • Medulloblastoma
  • Quantitative RT-PCR
  • ROX/MNT
  • c-MYC

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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