Analysis of the systemic corticosteroid sensitivity of patients with primary open-angle glaucoma

Kenneth A. Foon, Karen Yuen, Elmer J. Ballintine, David L. Rosenstreich

Research output: Contribution to journalArticle

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Abstract

Patients with primary open-angle glaucoma have an ocular and systemic sensitivity to corticosteroids. We adapted a cellular assay that used peripheral blood lymphocytes to detect this corticosteroid sensitivity in vitro in a microtiter assay. It reduced the time, cost, and amount of blood required to examine a patient. We examined ten subjects on three separate days and demonstrated that the reliability of one 50% inhibitory concentration was about 76%. We then studied 25 patients with primary open-angle glaucoma and 25 control subjects using this in vitro assay. The patients with primary open-angle glaucoma were significantly more sensitive to corticosteroids than the control subjects (P < .001).

Original languageEnglish (US)
Pages (from-to)167-173
Number of pages7
JournalAmerican Journal of Ophthalmology
Volume83
Issue number2
StatePublished - 1977
Externally publishedYes

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Adrenal Cortex Hormones
Inhibitory Concentration 50
Lymphocytes
Costs and Cost Analysis
Primary Open Angle Glaucoma
In Vitro Techniques

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Analysis of the systemic corticosteroid sensitivity of patients with primary open-angle glaucoma. / Foon, Kenneth A.; Yuen, Karen; Ballintine, Elmer J.; Rosenstreich, David L.

In: American Journal of Ophthalmology, Vol. 83, No. 2, 1977, p. 167-173.

Research output: Contribution to journalArticle

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