Analysis of the systemic corticosteroid sensitivity of patients with primary open-angle glaucoma

Kenneth A. Foon, Karen Yuen, Elmer J. Ballintine, David L. Rosenstreich

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Patients with primary open-angle glaucoma have an ocular and systemic sensitivity to corticosteroids. We adapted a cellular assay that used peripheral blood lymphocytes to detect this corticosteroid sensitivity in vitro in a microtiter assay. It reduced the time, cost, and amount of blood required to examine a patient. We examined ten subjects on three separate days and demonstrated that the reliability of one 50% inhibitory concentration was about 76%. We then studied 25 patients with primary open-angle glaucoma and 25 control subjects using this in vitro assay. The patients with primary open-angle glaucoma were significantly more sensitive to corticosteroids than the control subjects (P < .001).

Original languageEnglish (US)
Pages (from-to)167-173
Number of pages7
JournalAmerican journal of ophthalmology
Volume83
Issue number2
DOIs
StatePublished - Feb 1977

ASJC Scopus subject areas

  • Ophthalmology

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