Analysis of the β-tubulin genes from Enterocytozoon bieneusi isolates from a human and rhesus macaque

Donna E. Akiyoshi; Louis M. Weiss; Xiaochuan Feng; Bryony A.P. Williams; Patrick J. Keeling; Quanshun Zhang; Saul Tzipori

doi:10.1111/j.1550-7408.2006.00140.x

Analysis of the β-tubulin genes from Enterocytozoon bieneusi isolates from a human and rhesus macaque

Donna E. Akiyoshi, Louis M. Weiss, Xiaochuan Feng, Bryony A.P. Williams, Patrick J. Keeling, Quanshun Zhang, Saul Tzipori

Pathology

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

Enterocytozoon bieneusi is the most common and clinically significant microsporidium associated with chronic diarrhea and wasting in immunocompromised humans. Albendazole, which is effective against several helminths, protozoa, and microsporidia, is relatively ineffective against infections due to E. bieneusi. A likely explanation for the observed clinical resistance to albendazole was discovered from sequence analysis of the E. bieneusi β-tubulin from isolates from an infected human and a naturally infected rhesus macaque. The β-tubulin of E. bieneusi has a substitution at Glu ₁₉₈, which is one of six amino acids reported to be associated with benzimidazole sensitivity.

Original language	English (US)
Pages (from-to)	38-41
Number of pages	4
Journal	Journal of Eukaryotic Microbiology
Volume	54
Issue number	1
DOIs	https://doi.org/10.1111/j.1550-7408.2006.00140.x
State	Published - Jan 2007

Keywords

Albendazole resistance
Beta-tubulin gene
Microsporidia

ASJC Scopus subject areas

Microbiology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1111/j.1550-7408.2006.00140.x

Cite this

@article{ae692d0dc014495bb3cdb15fdc5166e2,

title = "Analysis of the β-tubulin genes from Enterocytozoon bieneusi isolates from a human and rhesus macaque",

abstract = "Enterocytozoon bieneusi is the most common and clinically significant microsporidium associated with chronic diarrhea and wasting in immunocompromised humans. Albendazole, which is effective against several helminths, protozoa, and microsporidia, is relatively ineffective against infections due to E. bieneusi. A likely explanation for the observed clinical resistance to albendazole was discovered from sequence analysis of the E. bieneusi β-tubulin from isolates from an infected human and a naturally infected rhesus macaque. The β-tubulin of E. bieneusi has a substitution at Glu 198, which is one of six amino acids reported to be associated with benzimidazole sensitivity.",

keywords = "Albendazole resistance, Beta-tubulin gene, Microsporidia",

author = "Akiyoshi, {Donna E.} and Weiss, {Louis M.} and Xiaochuan Feng and Williams, {Bryony A.P.} and Keeling, {Patrick J.} and Quanshun Zhang and Saul Tzipori",

year = "2007",

month = jan,

doi = "10.1111/j.1550-7408.2006.00140.x",

language = "English (US)",

volume = "54",

pages = "38--41",

journal = "Journal of Eukaryotic Microbiology",

issn = "1066-5234",

publisher = "Wiley-Blackwell",

number = "1",

}

TY - JOUR

T1 - Analysis of the β-tubulin genes from Enterocytozoon bieneusi isolates from a human and rhesus macaque

AU - Akiyoshi, Donna E.

AU - Weiss, Louis M.

AU - Feng, Xiaochuan

AU - Williams, Bryony A.P.

AU - Keeling, Patrick J.

AU - Zhang, Quanshun

AU - Tzipori, Saul

PY - 2007/1

Y1 - 2007/1

N2 - Enterocytozoon bieneusi is the most common and clinically significant microsporidium associated with chronic diarrhea and wasting in immunocompromised humans. Albendazole, which is effective against several helminths, protozoa, and microsporidia, is relatively ineffective against infections due to E. bieneusi. A likely explanation for the observed clinical resistance to albendazole was discovered from sequence analysis of the E. bieneusi β-tubulin from isolates from an infected human and a naturally infected rhesus macaque. The β-tubulin of E. bieneusi has a substitution at Glu 198, which is one of six amino acids reported to be associated with benzimidazole sensitivity.

AB - Enterocytozoon bieneusi is the most common and clinically significant microsporidium associated with chronic diarrhea and wasting in immunocompromised humans. Albendazole, which is effective against several helminths, protozoa, and microsporidia, is relatively ineffective against infections due to E. bieneusi. A likely explanation for the observed clinical resistance to albendazole was discovered from sequence analysis of the E. bieneusi β-tubulin from isolates from an infected human and a naturally infected rhesus macaque. The β-tubulin of E. bieneusi has a substitution at Glu 198, which is one of six amino acids reported to be associated with benzimidazole sensitivity.

KW - Albendazole resistance

KW - Beta-tubulin gene

KW - Microsporidia

UR - http://www.scopus.com/inward/record.url?scp=33846645044&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33846645044&partnerID=8YFLogxK

U2 - 10.1111/j.1550-7408.2006.00140.x

DO - 10.1111/j.1550-7408.2006.00140.x

M3 - Article

C2 - 17300517

AN - SCOPUS:33846645044

SN - 1066-5234

VL - 54

SP - 38

EP - 41

JO - Journal of Eukaryotic Microbiology

JF - Journal of Eukaryotic Microbiology

IS - 1

ER -

Analysis of the β-tubulin genes from Enterocytozoon bieneusi isolates from a human and rhesus macaque

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this