Analysis of the β-tubulin genes from Enterocytozoon bieneusi isolates from a human and rhesus macaque

Donna E. Akiyoshi, Louis M. Weiss, Xiaochuan Feng, Bryony A.P. Williams, Patrick J. Keeling, Quanshun Zhang, Saul Tzipori

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Abstract

Enterocytozoon bieneusi is the most common and clinically significant microsporidium associated with chronic diarrhea and wasting in immunocompromised humans. Albendazole, which is effective against several helminths, protozoa, and microsporidia, is relatively ineffective against infections due to E. bieneusi. A likely explanation for the observed clinical resistance to albendazole was discovered from sequence analysis of the E. bieneusi β-tubulin from isolates from an infected human and a naturally infected rhesus macaque. The β-tubulin of E. bieneusi has a substitution at Glu 198, which is one of six amino acids reported to be associated with benzimidazole sensitivity.

Original languageEnglish (US)
Pages (from-to)38-41
Number of pages4
JournalJournal of Eukaryotic Microbiology
Volume54
Issue number1
DOIs
StatePublished - Jan 1 2007

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Keywords

  • Albendazole resistance
  • Beta-tubulin gene
  • Microsporidia

ASJC Scopus subject areas

  • Microbiology

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