Abstract
To investigate the role of insulin-like growth factor-1 (IGF-1), in localized osteosarcoma, serum levels of IGF-1, IGFBP-2, and IGFBP-3 were measured in 224 similarly treated, newly diagnosed patients. We demonstrated that younger patients had lower concentrations of IGF-1 and IGFBP-3 compared to older (P<0.001) along with lower IGFBP-3:IGF-1 and IGFBP-2:IGF-1 ratios (P<0.001). IGFBP-2 did not correlate with age (P=0.16), yet IGFBP-2:IGF-1 ratios were higher in the younger population (P<0.001). These findings show that older patients have higher concentrations of free IGF-1. None of IGF-1, IGFBP-2, nor IGFBP-3 concentrations were associated with event-free nor overall survival.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 749-752 |
| Number of pages | 4 |
| Journal | Pediatric Blood and Cancer |
| Volume | 61 |
| Issue number | 4 |
| DOIs | |
| State | Published - Apr 2014 |
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Keywords
- Cancer biology
- Clinical trials
- Osteosarcoma
ASJC Scopus subject areas
- Oncology
- Pediatrics, Perinatology, and Child Health
- Hematology
Cite this
Analysis of serum insulin growth factor-1 concentrations in localized osteosarcoma : A children's oncology group study. / Borinstein, Scott C.; Barkauskas, Donald A.; Bernstein, Mark; Goorin, Allen; Gorlick, Richard; Krailo, Mark; Schwartz, Cindy L.; Wexler, Leonard H.; Toretsky, Jeffrey A.
In: Pediatric Blood and Cancer, Vol. 61, No. 4, 04.2014, p. 749-752.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Analysis of serum insulin growth factor-1 concentrations in localized osteosarcoma
T2 - A children's oncology group study
AU - Borinstein, Scott C.
AU - Barkauskas, Donald A.
AU - Bernstein, Mark
AU - Goorin, Allen
AU - Gorlick, Richard
AU - Krailo, Mark
AU - Schwartz, Cindy L.
AU - Wexler, Leonard H.
AU - Toretsky, Jeffrey A.
PY - 2014/4
Y1 - 2014/4
N2 - To investigate the role of insulin-like growth factor-1 (IGF-1), in localized osteosarcoma, serum levels of IGF-1, IGFBP-2, and IGFBP-3 were measured in 224 similarly treated, newly diagnosed patients. We demonstrated that younger patients had lower concentrations of IGF-1 and IGFBP-3 compared to older (P<0.001) along with lower IGFBP-3:IGF-1 and IGFBP-2:IGF-1 ratios (P<0.001). IGFBP-2 did not correlate with age (P=0.16), yet IGFBP-2:IGF-1 ratios were higher in the younger population (P<0.001). These findings show that older patients have higher concentrations of free IGF-1. None of IGF-1, IGFBP-2, nor IGFBP-3 concentrations were associated with event-free nor overall survival.
AB - To investigate the role of insulin-like growth factor-1 (IGF-1), in localized osteosarcoma, serum levels of IGF-1, IGFBP-2, and IGFBP-3 were measured in 224 similarly treated, newly diagnosed patients. We demonstrated that younger patients had lower concentrations of IGF-1 and IGFBP-3 compared to older (P<0.001) along with lower IGFBP-3:IGF-1 and IGFBP-2:IGF-1 ratios (P<0.001). IGFBP-2 did not correlate with age (P=0.16), yet IGFBP-2:IGF-1 ratios were higher in the younger population (P<0.001). These findings show that older patients have higher concentrations of free IGF-1. None of IGF-1, IGFBP-2, nor IGFBP-3 concentrations were associated with event-free nor overall survival.
KW - Cancer biology
KW - Clinical trials
KW - Osteosarcoma
UR - http://www.scopus.com/inward/record.url?scp=84893451918&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84893451918&partnerID=8YFLogxK
U2 - 10.1002/pbc.24778
DO - 10.1002/pbc.24778
M3 - Article
C2 - 24178953
AN - SCOPUS:84893451918
VL - 61
SP - 749
EP - 752
JO - Pediatric Blood and Cancer
JF - Pediatric Blood and Cancer
SN - 1545-5009
IS - 4
ER -