Analysis of serum insulin growth factor-1 concentrations in localized osteosarcoma: A children's oncology group study

Scott C. Borinstein; Donald A. Barkauskas; Mark Bernstein; Allen Goorin; Richard Gorlick; Mark Krailo; Cindy L. Schwartz; Leonard H. Wexler; Jeffrey A. Toretsky

doi:10.1002/pbc.24778

Analysis of serum insulin growth factor-1 concentrations in localized osteosarcoma: A children's oncology group study

Scott C. Borinstein, Donald A. Barkauskas, Mark Bernstein, Allen Goorin, Richard Gorlick, Mark Krailo, Cindy L. Schwartz, Leonard H. Wexler, Jeffrey A. Toretsky

Pediatrics

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

To investigate the role of insulin-like growth factor-1 (IGF-1), in localized osteosarcoma, serum levels of IGF-1, IGFBP-2, and IGFBP-3 were measured in 224 similarly treated, newly diagnosed patients. We demonstrated that younger patients had lower concentrations of IGF-1 and IGFBP-3 compared to older (P<0.001) along with lower IGFBP-3:IGF-1 and IGFBP-2:IGF-1 ratios (P<0.001). IGFBP-2 did not correlate with age (P=0.16), yet IGFBP-2:IGF-1 ratios were higher in the younger population (P<0.001). These findings show that older patients have higher concentrations of free IGF-1. None of IGF-1, IGFBP-2, nor IGFBP-3 concentrations were associated with event-free nor overall survival.

Original language	English (US)
Pages (from-to)	749-752
Number of pages	4
Journal	Pediatric Blood and Cancer
Volume	61
Issue number	4
DOIs	https://doi.org/10.1002/pbc.24778
State	Published - Apr 2014

Keywords

Cancer biology
Clinical trials
Osteosarcoma

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Hematology
Oncology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/pbc.24778

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title = "Analysis of serum insulin growth factor-1 concentrations in localized osteosarcoma: A children's oncology group study",

abstract = "To investigate the role of insulin-like growth factor-1 (IGF-1), in localized osteosarcoma, serum levels of IGF-1, IGFBP-2, and IGFBP-3 were measured in 224 similarly treated, newly diagnosed patients. We demonstrated that younger patients had lower concentrations of IGF-1 and IGFBP-3 compared to older (P<0.001) along with lower IGFBP-3:IGF-1 and IGFBP-2:IGF-1 ratios (P<0.001). IGFBP-2 did not correlate with age (P=0.16), yet IGFBP-2:IGF-1 ratios were higher in the younger population (P<0.001). These findings show that older patients have higher concentrations of free IGF-1. None of IGF-1, IGFBP-2, nor IGFBP-3 concentrations were associated with event-free nor overall survival.",

keywords = "Cancer biology, Clinical trials, Osteosarcoma",

author = "Borinstein, {Scott C.} and Barkauskas, {Donald A.} and Mark Bernstein and Allen Goorin and Richard Gorlick and Mark Krailo and Schwartz, {Cindy L.} and Wexler, {Leonard H.} and Toretsky, {Jeffrey A.}",

year = "2014",

month = apr,

doi = "10.1002/pbc.24778",

language = "English (US)",

volume = "61",

pages = "749--752",

journal = "Pediatric Blood and Cancer",

issn = "1545-5009",

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T2 - A children's oncology group study

AU - Borinstein, Scott C.

AU - Barkauskas, Donald A.

AU - Bernstein, Mark

AU - Goorin, Allen

AU - Gorlick, Richard

AU - Krailo, Mark

AU - Schwartz, Cindy L.

AU - Wexler, Leonard H.

AU - Toretsky, Jeffrey A.

PY - 2014/4

Y1 - 2014/4

N2 - To investigate the role of insulin-like growth factor-1 (IGF-1), in localized osteosarcoma, serum levels of IGF-1, IGFBP-2, and IGFBP-3 were measured in 224 similarly treated, newly diagnosed patients. We demonstrated that younger patients had lower concentrations of IGF-1 and IGFBP-3 compared to older (P<0.001) along with lower IGFBP-3:IGF-1 and IGFBP-2:IGF-1 ratios (P<0.001). IGFBP-2 did not correlate with age (P=0.16), yet IGFBP-2:IGF-1 ratios were higher in the younger population (P<0.001). These findings show that older patients have higher concentrations of free IGF-1. None of IGF-1, IGFBP-2, nor IGFBP-3 concentrations were associated with event-free nor overall survival.

AB - To investigate the role of insulin-like growth factor-1 (IGF-1), in localized osteosarcoma, serum levels of IGF-1, IGFBP-2, and IGFBP-3 were measured in 224 similarly treated, newly diagnosed patients. We demonstrated that younger patients had lower concentrations of IGF-1 and IGFBP-3 compared to older (P<0.001) along with lower IGFBP-3:IGF-1 and IGFBP-2:IGF-1 ratios (P<0.001). IGFBP-2 did not correlate with age (P=0.16), yet IGFBP-2:IGF-1 ratios were higher in the younger population (P<0.001). These findings show that older patients have higher concentrations of free IGF-1. None of IGF-1, IGFBP-2, nor IGFBP-3 concentrations were associated with event-free nor overall survival.

KW - Cancer biology

KW - Clinical trials

KW - Osteosarcoma

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M3 - Article

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JO - Pediatric Blood and Cancer

JF - Pediatric Blood and Cancer

IS - 4

ER -

Analysis of serum insulin growth factor-1 concentrations in localized osteosarcoma: A children's oncology group study

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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