Analysis of serum insulin growth factor-1 concentrations in localized osteosarcoma: A children's oncology group study

Scott C. Borinstein; Donald A. Barkauskas; Mark Bernstein; Allen Goorin; Richard Gorlick; Mark Krailo; Cindy L. Schwartz; Leonard H. Wexler; Jeffrey A. Toretsky

doi:10.1002/pbc.24778

Analysis of serum insulin growth factor-1 concentrations in localized osteosarcoma: A children's oncology group study

Scott C. Borinstein, Donald A. Barkauskas, Mark Bernstein, Allen Goorin, Richard Gorlick, Mark Krailo, Cindy L. Schwartz, Leonard H. Wexler, Jeffrey A. Toretsky

Pediatrics

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

To investigate the role of insulin-like growth factor-1 (IGF-1), in localized osteosarcoma, serum levels of IGF-1, IGFBP-2, and IGFBP-3 were measured in 224 similarly treated, newly diagnosed patients. We demonstrated that younger patients had lower concentrations of IGF-1 and IGFBP-3 compared to older (P<0.001) along with lower IGFBP-3:IGF-1 and IGFBP-2:IGF-1 ratios (P<0.001). IGFBP-2 did not correlate with age (P=0.16), yet IGFBP-2:IGF-1 ratios were higher in the younger population (P<0.001). These findings show that older patients have higher concentrations of free IGF-1. None of IGF-1, IGFBP-2, nor IGFBP-3 concentrations were associated with event-free nor overall survival.

Original language	English (US)
Pages (from-to)	749-752
Number of pages	4
Journal	Pediatric Blood and Cancer
Volume	61
Issue number	4
DOIs	https://doi.org/10.1002/pbc.24778
State	Published - Apr 2014

Keywords

Cancer biology
Clinical trials
Osteosarcoma

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Hematology
Oncology

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10.1002/pbc.24778

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Analysis of serum insulin growth factor-1 concentrations in localized osteosarcoma : A children's oncology group study. / Borinstein, Scott C.; Barkauskas, Donald A.; Bernstein, Mark; Goorin, Allen; Gorlick, Richard; Krailo, Mark; Schwartz, Cindy L.; Wexler, Leonard H.; Toretsky, Jeffrey A.

In: Pediatric Blood and Cancer, Vol. 61, No. 4, 04.2014, p. 749-752.

Research output: Contribution to journal › Article › peer-review

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abstract = "To investigate the role of insulin-like growth factor-1 (IGF-1), in localized osteosarcoma, serum levels of IGF-1, IGFBP-2, and IGFBP-3 were measured in 224 similarly treated, newly diagnosed patients. We demonstrated that younger patients had lower concentrations of IGF-1 and IGFBP-3 compared to older (P<0.001) along with lower IGFBP-3:IGF-1 and IGFBP-2:IGF-1 ratios (P<0.001). IGFBP-2 did not correlate with age (P=0.16), yet IGFBP-2:IGF-1 ratios were higher in the younger population (P<0.001). These findings show that older patients have higher concentrations of free IGF-1. None of IGF-1, IGFBP-2, nor IGFBP-3 concentrations were associated with event-free nor overall survival.",

keywords = "Cancer biology, Clinical trials, Osteosarcoma",

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AU - Gorlick, Richard

AU - Krailo, Mark

AU - Schwartz, Cindy L.

AU - Wexler, Leonard H.

AU - Toretsky, Jeffrey A.

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AB - To investigate the role of insulin-like growth factor-1 (IGF-1), in localized osteosarcoma, serum levels of IGF-1, IGFBP-2, and IGFBP-3 were measured in 224 similarly treated, newly diagnosed patients. We demonstrated that younger patients had lower concentrations of IGF-1 and IGFBP-3 compared to older (P<0.001) along with lower IGFBP-3:IGF-1 and IGFBP-2:IGF-1 ratios (P<0.001). IGFBP-2 did not correlate with age (P=0.16), yet IGFBP-2:IGF-1 ratios were higher in the younger population (P<0.001). These findings show that older patients have higher concentrations of free IGF-1. None of IGF-1, IGFBP-2, nor IGFBP-3 concentrations were associated with event-free nor overall survival.

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Analysis of serum insulin growth factor-1 concentrations in localized osteosarcoma: A children's oncology group study

Abstract

Keywords

ASJC Scopus subject areas

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