Analysis of serum insulin growth factor-1 concentrations in localized osteosarcoma: A children's oncology group study

Scott C. Borinstein, Donald A. Barkauskas, Mark Bernstein, Allen Goorin, Richard Gorlick, Mark Krailo, Cindy L. Schwartz, Leonard H. Wexler, Jeffrey A. Toretsky

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

To investigate the role of insulin-like growth factor-1 (IGF-1), in localized osteosarcoma, serum levels of IGF-1, IGFBP-2, and IGFBP-3 were measured in 224 similarly treated, newly diagnosed patients. We demonstrated that younger patients had lower concentrations of IGF-1 and IGFBP-3 compared to older (P<0.001) along with lower IGFBP-3:IGF-1 and IGFBP-2:IGF-1 ratios (P<0.001). IGFBP-2 did not correlate with age (P=0.16), yet IGFBP-2:IGF-1 ratios were higher in the younger population (P<0.001). These findings show that older patients have higher concentrations of free IGF-1. None of IGF-1, IGFBP-2, nor IGFBP-3 concentrations were associated with event-free nor overall survival.

Original languageEnglish (US)
Pages (from-to)749-752
Number of pages4
JournalPediatric Blood and Cancer
Volume61
Issue number4
DOIs
StatePublished - Apr 1 2014

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Keywords

  • Cancer biology
  • Clinical trials
  • Osteosarcoma

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

Cite this

Borinstein, S. C., Barkauskas, D. A., Bernstein, M., Goorin, A., Gorlick, R., Krailo, M., Schwartz, C. L., Wexler, L. H., & Toretsky, J. A. (2014). Analysis of serum insulin growth factor-1 concentrations in localized osteosarcoma: A children's oncology group study. Pediatric Blood and Cancer, 61(4), 749-752. https://doi.org/10.1002/pbc.24778