TY - JOUR
T1 - Analysis of risk factors for chronic hepatic encephalopathy
T2 - The role of Helicobacter pylori infection
AU - Dasani, Bharat M.
AU - Sigal, Samuel H.
AU - Lieber, Charles S.
N1 - Funding Information:
Supported in part by the Department of Veterans Affairs, National Institutes of Health grants AA07275 and AA03508, and the Kingsbridge Research Foundation.
PY - 1998/5
Y1 - 1998/5
N2 - Objective: Elevated blood ammonia is an important pathogenic factor of hepatic encephalopathy. Although colonic bacteria are considered the main source of ammonia, the stomach in subjects with urease-producing Helicobacter pylori (H. pylori) is an alternative site. The objective of this study was to determine whether H. pylori is associated with this complication. Methods: After assessing liver function and portal hypertension, 55 cirrhotics were evaluated for encephalopathy and H. pylori infection. Response to 2 weeks of amoxicillin (2 g/day) and omeprazole (40 mg/day) was then assessed in 17 (13 H. pylori-positive, four H. pylori-negative) encephalopathic subjects. Results: H. pylori infection was more common (67% vs 33%, p = 0.004) among encephalopathic patients. Additional factors associated with encephalopathy included older age (60.1 ± 1.5 vs 49.8 ± 2.4 yr, p = 0.001), lower albumin (3.17 ± 0.08 vs 3.69 ± 0.12 g/dl, p = 0.001), higher total bilirubin (2.24 ± 0.20 vs 1.53 ± 0.23 mg/dl, p = 0.034), greater ascites score (0.8 ± 0.1 vs 0.3 ± 0.1, p = 0.01), greater diuretic score (1.1 ± 0.1 vs 0.3 ± 0.1, p = 0.002), and greater modified Child score (6.7 ± 0.3 vs 5.1 ± 0.3, p = 0.001). When adjusted for severity of cirrhosis and age, H. pylori continued to demonstrate a statistical association (p = 0.039). After anti-H. pylori therapy, symptomatology in infected encephalopathic patients appeared to improve, whereas noninfected subjects were unaffected. Conclusion: In cirrhotic patients, H. pylori infection is associated with hepatic encephalopathy, especially in younger patients with decompensated liver disease.
AB - Objective: Elevated blood ammonia is an important pathogenic factor of hepatic encephalopathy. Although colonic bacteria are considered the main source of ammonia, the stomach in subjects with urease-producing Helicobacter pylori (H. pylori) is an alternative site. The objective of this study was to determine whether H. pylori is associated with this complication. Methods: After assessing liver function and portal hypertension, 55 cirrhotics were evaluated for encephalopathy and H. pylori infection. Response to 2 weeks of amoxicillin (2 g/day) and omeprazole (40 mg/day) was then assessed in 17 (13 H. pylori-positive, four H. pylori-negative) encephalopathic subjects. Results: H. pylori infection was more common (67% vs 33%, p = 0.004) among encephalopathic patients. Additional factors associated with encephalopathy included older age (60.1 ± 1.5 vs 49.8 ± 2.4 yr, p = 0.001), lower albumin (3.17 ± 0.08 vs 3.69 ± 0.12 g/dl, p = 0.001), higher total bilirubin (2.24 ± 0.20 vs 1.53 ± 0.23 mg/dl, p = 0.034), greater ascites score (0.8 ± 0.1 vs 0.3 ± 0.1, p = 0.01), greater diuretic score (1.1 ± 0.1 vs 0.3 ± 0.1, p = 0.002), and greater modified Child score (6.7 ± 0.3 vs 5.1 ± 0.3, p = 0.001). When adjusted for severity of cirrhosis and age, H. pylori continued to demonstrate a statistical association (p = 0.039). After anti-H. pylori therapy, symptomatology in infected encephalopathic patients appeared to improve, whereas noninfected subjects were unaffected. Conclusion: In cirrhotic patients, H. pylori infection is associated with hepatic encephalopathy, especially in younger patients with decompensated liver disease.
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U2 - 10.1111/j.1572-0241.1998.214_a.x
DO - 10.1111/j.1572-0241.1998.214_a.x
M3 - Article
C2 - 9625117
AN - SCOPUS:0032081008
SN - 0002-9270
VL - 93
SP - 726
EP - 731
JO - American Journal of Gastroenterology
JF - American Journal of Gastroenterology
IS - 5
ER -