Analysis of Rejection Episodes in Over 100 Pediatric Intestinal Transplant Recipients

G. Selvaggi, T. Kato, J. J. Gaynor, John F. Thompson, S. Nishida, J. Madariaga, D. Levi, J. Moon, P. Ruiz, P. Cantwell, S. Tuteja, A. Tzakis

Research output: Contribution to journalArticle

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Abstract

Rejection after intestinal transplant is a significant source of morbidity and mortality. We analyzed number of rejections, severity, and duration of episodes in pediatric recipients of intestinal transplants. One hundred eighteen intestinal transplants were performed: intestine (n = 27), liver-intestine (n = 27), modified multivisceral (n = 7), and multivisceral (n = 57). A total of 186 rejections were classified: mild (n = 89), moderate (n = 70), severe (n = 27). Duration of episodes doubled for each increasing step in severity. Treatment of mild rejection was with steroids, moderate rejection was treated with OKT3, severe rejection required OKT3 and organ removal. Most rejections occurred during the first month posttransplant, with the incidence of all rejections declining after 6 months posttransplant. Intestine and liver-intestine recipients had significantly higher probability of developing severe rejections, as compared to MVT. In summary, recipients of MVT seemed to be protected from rejection as compared to intestine or liver-intestine recipients.

Original languageEnglish (US)
Pages (from-to)1711-1712
Number of pages2
JournalTransplantation Proceedings
Volume38
Issue number6
DOIs
StatePublished - Jul 2006
Externally publishedYes

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Intestines
Pediatrics
Muromonab-CD3
Liver
Transplants
Transplant Recipients
Steroids
Morbidity
Mortality
Incidence

ASJC Scopus subject areas

  • Surgery
  • Transplantation

Cite this

Analysis of Rejection Episodes in Over 100 Pediatric Intestinal Transplant Recipients. / Selvaggi, G.; Kato, T.; Gaynor, J. J.; Thompson, John F.; Nishida, S.; Madariaga, J.; Levi, D.; Moon, J.; Ruiz, P.; Cantwell, P.; Tuteja, S.; Tzakis, A.

In: Transplantation Proceedings, Vol. 38, No. 6, 07.2006, p. 1711-1712.

Research output: Contribution to journalArticle

Selvaggi, G, Kato, T, Gaynor, JJ, Thompson, JF, Nishida, S, Madariaga, J, Levi, D, Moon, J, Ruiz, P, Cantwell, P, Tuteja, S & Tzakis, A 2006, 'Analysis of Rejection Episodes in Over 100 Pediatric Intestinal Transplant Recipients', Transplantation Proceedings, vol. 38, no. 6, pp. 1711-1712. https://doi.org/10.1016/j.transproceed.2006.05.061
Selvaggi, G. ; Kato, T. ; Gaynor, J. J. ; Thompson, John F. ; Nishida, S. ; Madariaga, J. ; Levi, D. ; Moon, J. ; Ruiz, P. ; Cantwell, P. ; Tuteja, S. ; Tzakis, A. / Analysis of Rejection Episodes in Over 100 Pediatric Intestinal Transplant Recipients. In: Transplantation Proceedings. 2006 ; Vol. 38, No. 6. pp. 1711-1712.
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