Analysis of interacting cell populations in cultures of marrow from patients with neutropenia

J. S. Senn, H. A. Messner, E. R. Stanley

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Utilizing an adherence separation procedure, marrow cells from six neutropenic patients were studied in cell culture for colony forming ability (CFU C), and for colony stimulating function of the adherent cell (A C) population. Assays on 2 patients showed reduced CFU C and A C function, while assays on 3 patients yielded normal CFU C and A C function; studies on the remaining patient exhibited reduced CFU C in the presence of normal A C function. The demonstration of these various abnormalities in marrow cell culture from neutropenic patients suggests that the in vitro techniques have relevance to the study of granulopoiesis in vivo.

Original languageEnglish (US)
Pages (from-to)33-40
Number of pages8
JournalBlood
Volume44
Issue number1
StatePublished - 1974
Externally publishedYes

Fingerprint

Neutropenia
Cell culture
Bone Marrow
Cells
Population
Assays
Cell Culture Techniques
Demonstrations

ASJC Scopus subject areas

  • Hematology

Cite this

Senn, J. S., Messner, H. A., & Stanley, E. R. (1974). Analysis of interacting cell populations in cultures of marrow from patients with neutropenia. Blood, 44(1), 33-40.

Analysis of interacting cell populations in cultures of marrow from patients with neutropenia. / Senn, J. S.; Messner, H. A.; Stanley, E. R.

In: Blood, Vol. 44, No. 1, 1974, p. 33-40.

Research output: Contribution to journalArticle

Senn, JS, Messner, HA & Stanley, ER 1974, 'Analysis of interacting cell populations in cultures of marrow from patients with neutropenia', Blood, vol. 44, no. 1, pp. 33-40.
Senn, J. S. ; Messner, H. A. ; Stanley, E. R. / Analysis of interacting cell populations in cultures of marrow from patients with neutropenia. In: Blood. 1974 ; Vol. 44, No. 1. pp. 33-40.
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