Analyses of Factors Affecting Endothelial Cell Density in an Eye Bank Corneal Donor Database

Ji Won Kwon, Kyong Jin Cho, Hong Kyu Kim, Jimmy K. Lee, Patrick K. Gore, Mitchell D. McCartney, Roy S. Chuck

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

PURPOSE:: To analyze the factors affecting central corneal endothelial cell density (ECD) in an eye bank corneal donor database. METHODS:: The Lionʼs Eye Institute corneal donor database consisting of 18,665 donors (34,234 corneas) aged 20 years or older was analyzed. In particular, differences in the ECD based on age, sex, race, prior ocular surgery, a history of systemic diseases, and smoking were investigated. Furthermore, risk factors for donor cell count inadequacy (defined here as ECD less than 2000/mm) were identified. RESULTS:: ECD decreased with age. Regarding race, the average ECD of African American donors was higher than those of white or Hispanic donors. A history of diabetes mellitus (DM) and ocular surgery were associated with a lower ECD. Donor medical history of hypertension, glaucoma, depression, dementia, Parkinson disease, hyper- or hypothyroidism, or smoking did not seem to affect the ECD. The risk factors for donor cell count inadequacy, based on binary logistic regression analyses were advanced age [65–74 years yielded an odds ratio of 17.8; confidence interval (CI), 10.6–29.8; P <0.001; and 75–99 years yielded an odds ratio of 24.6 (CI, 14.5–41.61; P <0.001) when compared with 20–34 years], cataract surgery (odds ratio, 4.3; CI, 4.0–4.8; P <0.001), and DM (odds ratio, 1.2; CI, 1.1–1.3; P = 0.001). CONCLUSIONS:: Age, race, ocular surgery (cataract and refractive), and DM seem to significantly affect donor corneal ECD. Of these variables, age, a history of cataract surgery, and DM were found to be the greatest risk factors for inadequate donor cell density (less than 2000/mm).

Original languageEnglish (US)
JournalCornea
DOIs
StateAccepted/In press - Jun 15 2016

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Eye Banks
Statistical Factor Analysis
Endothelial Cells
Cell Count
Tissue Donors
Databases
Diabetes Mellitus
Odds Ratio
Confidence Intervals
Cataract
Smoking
Lions
Refractive Surgical Procedures
Hyperthyroidism
Hypothyroidism
Hispanic Americans
African Americans
Glaucoma
Cornea
Parkinson Disease

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Analyses of Factors Affecting Endothelial Cell Density in an Eye Bank Corneal Donor Database. / Kwon, Ji Won; Cho, Kyong Jin; Kim, Hong Kyu; Lee, Jimmy K.; Gore, Patrick K.; McCartney, Mitchell D.; Chuck, Roy S.

In: Cornea, 15.06.2016.

Research output: Contribution to journalArticle

Kwon, Ji Won ; Cho, Kyong Jin ; Kim, Hong Kyu ; Lee, Jimmy K. ; Gore, Patrick K. ; McCartney, Mitchell D. ; Chuck, Roy S. / Analyses of Factors Affecting Endothelial Cell Density in an Eye Bank Corneal Donor Database. In: Cornea. 2016.
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abstract = "PURPOSE:: To analyze the factors affecting central corneal endothelial cell density (ECD) in an eye bank corneal donor database. METHODS:: The Lionʼs Eye Institute corneal donor database consisting of 18,665 donors (34,234 corneas) aged 20 years or older was analyzed. In particular, differences in the ECD based on age, sex, race, prior ocular surgery, a history of systemic diseases, and smoking were investigated. Furthermore, risk factors for donor cell count inadequacy (defined here as ECD less than 2000/mm) were identified. RESULTS:: ECD decreased with age. Regarding race, the average ECD of African American donors was higher than those of white or Hispanic donors. A history of diabetes mellitus (DM) and ocular surgery were associated with a lower ECD. Donor medical history of hypertension, glaucoma, depression, dementia, Parkinson disease, hyper- or hypothyroidism, or smoking did not seem to affect the ECD. The risk factors for donor cell count inadequacy, based on binary logistic regression analyses were advanced age [65–74 years yielded an odds ratio of 17.8; confidence interval (CI), 10.6–29.8; P <0.001; and 75–99 years yielded an odds ratio of 24.6 (CI, 14.5–41.61; P <0.001) when compared with 20–34 years], cataract surgery (odds ratio, 4.3; CI, 4.0–4.8; P <0.001), and DM (odds ratio, 1.2; CI, 1.1–1.3; P = 0.001). CONCLUSIONS:: Age, race, ocular surgery (cataract and refractive), and DM seem to significantly affect donor corneal ECD. Of these variables, age, a history of cataract surgery, and DM were found to be the greatest risk factors for inadequate donor cell density (less than 2000/mm).",
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AU - McCartney, Mitchell D.

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N2 - PURPOSE:: To analyze the factors affecting central corneal endothelial cell density (ECD) in an eye bank corneal donor database. METHODS:: The Lionʼs Eye Institute corneal donor database consisting of 18,665 donors (34,234 corneas) aged 20 years or older was analyzed. In particular, differences in the ECD based on age, sex, race, prior ocular surgery, a history of systemic diseases, and smoking were investigated. Furthermore, risk factors for donor cell count inadequacy (defined here as ECD less than 2000/mm) were identified. RESULTS:: ECD decreased with age. Regarding race, the average ECD of African American donors was higher than those of white or Hispanic donors. A history of diabetes mellitus (DM) and ocular surgery were associated with a lower ECD. Donor medical history of hypertension, glaucoma, depression, dementia, Parkinson disease, hyper- or hypothyroidism, or smoking did not seem to affect the ECD. The risk factors for donor cell count inadequacy, based on binary logistic regression analyses were advanced age [65–74 years yielded an odds ratio of 17.8; confidence interval (CI), 10.6–29.8; P <0.001; and 75–99 years yielded an odds ratio of 24.6 (CI, 14.5–41.61; P <0.001) when compared with 20–34 years], cataract surgery (odds ratio, 4.3; CI, 4.0–4.8; P <0.001), and DM (odds ratio, 1.2; CI, 1.1–1.3; P = 0.001). CONCLUSIONS:: Age, race, ocular surgery (cataract and refractive), and DM seem to significantly affect donor corneal ECD. Of these variables, age, a history of cataract surgery, and DM were found to be the greatest risk factors for inadequate donor cell density (less than 2000/mm).

AB - PURPOSE:: To analyze the factors affecting central corneal endothelial cell density (ECD) in an eye bank corneal donor database. METHODS:: The Lionʼs Eye Institute corneal donor database consisting of 18,665 donors (34,234 corneas) aged 20 years or older was analyzed. In particular, differences in the ECD based on age, sex, race, prior ocular surgery, a history of systemic diseases, and smoking were investigated. Furthermore, risk factors for donor cell count inadequacy (defined here as ECD less than 2000/mm) were identified. RESULTS:: ECD decreased with age. Regarding race, the average ECD of African American donors was higher than those of white or Hispanic donors. A history of diabetes mellitus (DM) and ocular surgery were associated with a lower ECD. Donor medical history of hypertension, glaucoma, depression, dementia, Parkinson disease, hyper- or hypothyroidism, or smoking did not seem to affect the ECD. The risk factors for donor cell count inadequacy, based on binary logistic regression analyses were advanced age [65–74 years yielded an odds ratio of 17.8; confidence interval (CI), 10.6–29.8; P <0.001; and 75–99 years yielded an odds ratio of 24.6 (CI, 14.5–41.61; P <0.001) when compared with 20–34 years], cataract surgery (odds ratio, 4.3; CI, 4.0–4.8; P <0.001), and DM (odds ratio, 1.2; CI, 1.1–1.3; P = 0.001). CONCLUSIONS:: Age, race, ocular surgery (cataract and refractive), and DM seem to significantly affect donor corneal ECD. Of these variables, age, a history of cataract surgery, and DM were found to be the greatest risk factors for inadequate donor cell density (less than 2000/mm).

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