An update on the use of NOD mice to study autoimmune (Type 1) diabetes

Rodolfo José Chaparro, Teresa P. DiLorenzo

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

The widely used nonobese diabetic (NOD) mouse model of autoimmune (Type 1) diabetes mellitus shares multiple characteristics with the human disease, and studies employing this model continue to yield clinically relevant and important information. Here, we review some of the recent key findings obtained from NOD mouse investigations that have both advanced our understanding of disease pathogenesis and suggested new therapeutic targets and approaches. Areas discussed include antigen discovery, identification of genes and pathways contributing to disease susceptibility, development of strategies to image islet inflammation and the testing of therapeutics. We also review recent technical advances that, combined with an improved understanding of the NOD mouse models limitations, should work to ensure its popularity, utility and relevance in the years ahead.

Original languageEnglish (US)
Pages (from-to)939-955
Number of pages17
JournalExpert Review of Clinical Immunology
Volume6
Issue number6
DOIs
StatePublished - Nov 2010

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Inbred NOD Mouse
Type 1 Diabetes Mellitus
Disease Susceptibility
Genetic Association Studies
Inflammation
Antigens
Therapeutics

Keywords

  • antigens
  • autoimmune
  • diabetes
  • humanized mice
  • NOD mice
  • therapies
  • Type 1 diabetes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

An update on the use of NOD mice to study autoimmune (Type 1) diabetes. / Chaparro, Rodolfo José; DiLorenzo, Teresa P.

In: Expert Review of Clinical Immunology, Vol. 6, No. 6, 11.2010, p. 939-955.

Research output: Contribution to journalArticle

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