An update on the use of NOD mice to study autoimmune (Type 1) diabetes

Rodolfo José Chaparro, Teresa P. Dilorenzo

Research output: Contribution to journalReview article

40 Scopus citations

Abstract

The widely used nonobese diabetic (NOD) mouse model of autoimmune (Type 1) diabetes mellitus shares multiple characteristics with the human disease, and studies employing this model continue to yield clinically relevant and important information. Here, we review some of the recent key findings obtained from NOD mouse investigations that have both advanced our understanding of disease pathogenesis and suggested new therapeutic targets and approaches. Areas discussed include antigen discovery, identification of genes and pathways contributing to disease susceptibility, development of strategies to image islet inflammation and the testing of therapeutics. We also review recent technical advances that, combined with an improved understanding of the NOD mouse models limitations, should work to ensure its popularity, utility and relevance in the years ahead.

Original languageEnglish (US)
Pages (from-to)939-955
Number of pages17
JournalExpert Review of Clinical Immunology
Volume6
Issue number6
DOIs
StatePublished - Nov 1 2010

Keywords

  • NOD mice
  • Type 1 diabetes
  • antigens
  • autoimmune
  • diabetes
  • humanized mice
  • therapies

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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