An unusual cause of upper gastrointestinal bleeding: Duodenal GIST. A case report and literature review

Chinar Mehta, Vivek V. Gumaste, Anatoly Leytin, Aaron Walfish

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

A duodenal GIST is an unusual cause of upper gastrointestinal bleeding. Duodenal GISTs are rare and constitute 5% of all GISTs. A significant percentage of duodenal GISTs are located in the third and fourth portion of the duodenum and may not be detected on routine upper endoscopy. Push enteroscopy is necessary to locate these lesions. It is extremely important to differentiate a duodenal GIST from other submucosal tumors like leiomyomas, leiomyosarcomas or leiomyoblastomas which may present in a similar manner, because the treatment and prognosis differ significantly. Appropriate histological and immunohistiochemical staining is required to confirm the diagnosis. Surgical resection is the treatment of choice and may involve limited resection or a pancreaticoduodenectomy. Adjuvant therapy with Imatinib has been shown to prolong survival in patients with GIST in general.

Original languageEnglish (US)
Pages (from-to)347-351
Number of pages5
JournalActa Gastro-Enterologica Belgica
Volume74
Issue number2
StatePublished - Jun 2011
Externally publishedYes

Fingerprint

Hemorrhage
Epithelioid Leiomyoma
Pancreaticoduodenectomy
Leiomyosarcoma
Leiomyoma
Duodenum
Endoscopy
Therapeutics
Staining and Labeling
Survival
Neoplasms
Imatinib Mesylate

ASJC Scopus subject areas

  • Gastroenterology

Cite this

An unusual cause of upper gastrointestinal bleeding : Duodenal GIST. A case report and literature review. / Mehta, Chinar; Gumaste, Vivek V.; Leytin, Anatoly; Walfish, Aaron.

In: Acta Gastro-Enterologica Belgica, Vol. 74, No. 2, 06.2011, p. 347-351.

Research output: Contribution to journalArticle

Mehta, Chinar ; Gumaste, Vivek V. ; Leytin, Anatoly ; Walfish, Aaron. / An unusual cause of upper gastrointestinal bleeding : Duodenal GIST. A case report and literature review. In: Acta Gastro-Enterologica Belgica. 2011 ; Vol. 74, No. 2. pp. 347-351.
@article{b2b058d494b24c2aa09ab341f299d536,
title = "An unusual cause of upper gastrointestinal bleeding: Duodenal GIST. A case report and literature review",
abstract = "A duodenal GIST is an unusual cause of upper gastrointestinal bleeding. Duodenal GISTs are rare and constitute 5{\%} of all GISTs. A significant percentage of duodenal GISTs are located in the third and fourth portion of the duodenum and may not be detected on routine upper endoscopy. Push enteroscopy is necessary to locate these lesions. It is extremely important to differentiate a duodenal GIST from other submucosal tumors like leiomyomas, leiomyosarcomas or leiomyoblastomas which may present in a similar manner, because the treatment and prognosis differ significantly. Appropriate histological and immunohistiochemical staining is required to confirm the diagnosis. Surgical resection is the treatment of choice and may involve limited resection or a pancreaticoduodenectomy. Adjuvant therapy with Imatinib has been shown to prolong survival in patients with GIST in general.",
author = "Chinar Mehta and Gumaste, {Vivek V.} and Anatoly Leytin and Aaron Walfish",
year = "2011",
month = "6",
language = "English (US)",
volume = "74",
pages = "347--351",
journal = "Acta Gastro-Enterologica Belgica",
issn = "0001-5644",
publisher = "Universa Press",
number = "2",

}

TY - JOUR

T1 - An unusual cause of upper gastrointestinal bleeding

T2 - Duodenal GIST. A case report and literature review

AU - Mehta, Chinar

AU - Gumaste, Vivek V.

AU - Leytin, Anatoly

AU - Walfish, Aaron

PY - 2011/6

Y1 - 2011/6

N2 - A duodenal GIST is an unusual cause of upper gastrointestinal bleeding. Duodenal GISTs are rare and constitute 5% of all GISTs. A significant percentage of duodenal GISTs are located in the third and fourth portion of the duodenum and may not be detected on routine upper endoscopy. Push enteroscopy is necessary to locate these lesions. It is extremely important to differentiate a duodenal GIST from other submucosal tumors like leiomyomas, leiomyosarcomas or leiomyoblastomas which may present in a similar manner, because the treatment and prognosis differ significantly. Appropriate histological and immunohistiochemical staining is required to confirm the diagnosis. Surgical resection is the treatment of choice and may involve limited resection or a pancreaticoduodenectomy. Adjuvant therapy with Imatinib has been shown to prolong survival in patients with GIST in general.

AB - A duodenal GIST is an unusual cause of upper gastrointestinal bleeding. Duodenal GISTs are rare and constitute 5% of all GISTs. A significant percentage of duodenal GISTs are located in the third and fourth portion of the duodenum and may not be detected on routine upper endoscopy. Push enteroscopy is necessary to locate these lesions. It is extremely important to differentiate a duodenal GIST from other submucosal tumors like leiomyomas, leiomyosarcomas or leiomyoblastomas which may present in a similar manner, because the treatment and prognosis differ significantly. Appropriate histological and immunohistiochemical staining is required to confirm the diagnosis. Surgical resection is the treatment of choice and may involve limited resection or a pancreaticoduodenectomy. Adjuvant therapy with Imatinib has been shown to prolong survival in patients with GIST in general.

UR - http://www.scopus.com/inward/record.url?scp=80052903951&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80052903951&partnerID=8YFLogxK

M3 - Article

C2 - 21861323

AN - SCOPUS:80052903951

VL - 74

SP - 347

EP - 351

JO - Acta Gastro-Enterologica Belgica

JF - Acta Gastro-Enterologica Belgica

SN - 0001-5644

IS - 2

ER -