An unusual case of Cushing's syndrome, hilus cell tumor and polycystic ovaries

S. Korth Schutz, L. S. Levine, Irwin R. Merkatz, M. I. New

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

An unusual case of Cushing's syndrome in a 10 yr old girl is presented. The patient originally exhibited features of Cushing's syndrome and acanthosis nigricans, but still maintained dexamethasone suppressibility. Following adrenalectomy, virilization became more severe, leading to the diagnosis of polycystic ovary syndrome and hilus cell tumor of the right ovary. After bilateral wedge resection and removal of the ovarian tumor, virilism decreased only slightly. Pigmentation changes became more severe and extremely high levels of adrenocorticotropic hormone with incomplete suppression after hydrocortisone were noted. At this time, prolactin levels were elevated. A primary hypothalamic lesion is suggested in this patient, beginning as an unusual form of Cushing's syndrome with Nelson's syndrome following adrenalectomy. The process progressed over a 6 yr period to involve the luteinizing hormone ovarian axis with resultant virilism, polycystic ovaries and hilus cell tumor. Prolactin hypersecretion and acanthosis nigricans probably also reflect the hypothalamic disease process.

Original languageEnglish (US)
Pages (from-to)794-800
Number of pages7
JournalJournal of Clinical Endocrinology and Metabolism
Volume38
Issue number5
StatePublished - 1974
Externally publishedYes

Fingerprint

Virilism
Cushing Syndrome
Acanthosis Nigricans
Tumors
Ovary
Adrenalectomy
Prolactin
Hypothalamic Diseases
Nelson Syndrome
Neoplasms
Polycystic Ovary Syndrome
Pigmentation
Luteinizing Hormone
Adrenocorticotropic Hormone
Dexamethasone
Hydrocortisone

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

An unusual case of Cushing's syndrome, hilus cell tumor and polycystic ovaries. / Korth Schutz, S.; Levine, L. S.; Merkatz, Irwin R.; New, M. I.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 38, No. 5, 1974, p. 794-800.

Research output: Contribution to journalArticle

@article{7d0cf745b8094ae6a98879b2c1006f47,
title = "An unusual case of Cushing's syndrome, hilus cell tumor and polycystic ovaries",
abstract = "An unusual case of Cushing's syndrome in a 10 yr old girl is presented. The patient originally exhibited features of Cushing's syndrome and acanthosis nigricans, but still maintained dexamethasone suppressibility. Following adrenalectomy, virilization became more severe, leading to the diagnosis of polycystic ovary syndrome and hilus cell tumor of the right ovary. After bilateral wedge resection and removal of the ovarian tumor, virilism decreased only slightly. Pigmentation changes became more severe and extremely high levels of adrenocorticotropic hormone with incomplete suppression after hydrocortisone were noted. At this time, prolactin levels were elevated. A primary hypothalamic lesion is suggested in this patient, beginning as an unusual form of Cushing's syndrome with Nelson's syndrome following adrenalectomy. The process progressed over a 6 yr period to involve the luteinizing hormone ovarian axis with resultant virilism, polycystic ovaries and hilus cell tumor. Prolactin hypersecretion and acanthosis nigricans probably also reflect the hypothalamic disease process.",
author = "{Korth Schutz}, S. and Levine, {L. S.} and Merkatz, {Irwin R.} and New, {M. I.}",
year = "1974",
language = "English (US)",
volume = "38",
pages = "794--800",
journal = "Journal of Clinical Endocrinology and Metabolism",
issn = "0021-972X",
publisher = "The Endocrine Society",
number = "5",

}

TY - JOUR

T1 - An unusual case of Cushing's syndrome, hilus cell tumor and polycystic ovaries

AU - Korth Schutz, S.

AU - Levine, L. S.

AU - Merkatz, Irwin R.

AU - New, M. I.

PY - 1974

Y1 - 1974

N2 - An unusual case of Cushing's syndrome in a 10 yr old girl is presented. The patient originally exhibited features of Cushing's syndrome and acanthosis nigricans, but still maintained dexamethasone suppressibility. Following adrenalectomy, virilization became more severe, leading to the diagnosis of polycystic ovary syndrome and hilus cell tumor of the right ovary. After bilateral wedge resection and removal of the ovarian tumor, virilism decreased only slightly. Pigmentation changes became more severe and extremely high levels of adrenocorticotropic hormone with incomplete suppression after hydrocortisone were noted. At this time, prolactin levels were elevated. A primary hypothalamic lesion is suggested in this patient, beginning as an unusual form of Cushing's syndrome with Nelson's syndrome following adrenalectomy. The process progressed over a 6 yr period to involve the luteinizing hormone ovarian axis with resultant virilism, polycystic ovaries and hilus cell tumor. Prolactin hypersecretion and acanthosis nigricans probably also reflect the hypothalamic disease process.

AB - An unusual case of Cushing's syndrome in a 10 yr old girl is presented. The patient originally exhibited features of Cushing's syndrome and acanthosis nigricans, but still maintained dexamethasone suppressibility. Following adrenalectomy, virilization became more severe, leading to the diagnosis of polycystic ovary syndrome and hilus cell tumor of the right ovary. After bilateral wedge resection and removal of the ovarian tumor, virilism decreased only slightly. Pigmentation changes became more severe and extremely high levels of adrenocorticotropic hormone with incomplete suppression after hydrocortisone were noted. At this time, prolactin levels were elevated. A primary hypothalamic lesion is suggested in this patient, beginning as an unusual form of Cushing's syndrome with Nelson's syndrome following adrenalectomy. The process progressed over a 6 yr period to involve the luteinizing hormone ovarian axis with resultant virilism, polycystic ovaries and hilus cell tumor. Prolactin hypersecretion and acanthosis nigricans probably also reflect the hypothalamic disease process.

UR - http://www.scopus.com/inward/record.url?scp=0016241882&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0016241882&partnerID=8YFLogxK

M3 - Article

C2 - 4363071

AN - SCOPUS:0016241882

VL - 38

SP - 794

EP - 800

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

SN - 0021-972X

IS - 5

ER -