An unexpected bis-Ligation of S-nitrosothiols

Jiming Zhang, Hua Wang, Ming Xian

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

A bis-ligation reaction of S-nitrosothiols using triaryl substituted phosphine-thioester substrates has been developed. This reaction converts unstable primary S-nitrosothiols to stable disulfideiminophosphorane products in high yields under mild conditions. It can potentially be applied for the detection of S-nitrosation in protein systems.

Original languageEnglish (US)
Pages (from-to)3854-3855
Number of pages2
JournalJournal of the American Chemical Society
Volume131
Issue number11
DOIs
StatePublished - Mar 25 2009
Externally publishedYes

Fingerprint

S-Nitrosothiols
phosphine
Ligation
Nitrosation
Proteins
Substrates

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis
  • Biochemistry
  • Colloid and Surface Chemistry
  • Medicine(all)

Cite this

An unexpected bis-Ligation of S-nitrosothiols. / Zhang, Jiming; Wang, Hua; Xian, Ming.

In: Journal of the American Chemical Society, Vol. 131, No. 11, 25.03.2009, p. 3854-3855.

Research output: Contribution to journalArticle

Zhang, Jiming ; Wang, Hua ; Xian, Ming. / An unexpected bis-Ligation of S-nitrosothiols. In: Journal of the American Chemical Society. 2009 ; Vol. 131, No. 11. pp. 3854-3855.
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