An ultrastructural study of cultured human meningioma cells

K. Kawamoto, F. Herz, H. Kajikawa, A. Hirano

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Ultrastructural alterations in human meningioma cells grown in vitro are reported. In early passages the cells retain some of the characteristic features of the original tumors. These include interdigitations associated with intercellular junctional devices (e.g., desmosomes, gap junctions). However, with repeated subculture these features tend to be less frequent. Typical whorl formations are observed only in primary cultures. The nunber of cytoplasmic filaments, lipid inclusions and other dense bodies increases with time in culture. Cytoplasmic invaginations into nuclei and the appearance of very large cells become more frequent in repeatedly transferred cultures.

Original languageEnglish (US)
Pages (from-to)11-15
Number of pages5
JournalActa Neuropathologica
Issue number1-2
StatePublished - Jan 1 1979


  • Cell culture
  • Cell junctions
  • Meningioma
  • Ultrastructure

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Clinical Neurology
  • Cellular and Molecular Neuroscience

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