An orphan gyrB in the Mycobacterium smegmatis genome uncovered by comparative genomics

P. Jain, V. Nagaraja

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

DNA gyrase is an essential topoisomerase found in all bacteria. It is encoded by gyrB and gyrA genes. These genes are organized differently in different bacteria. Direct comparison of Mycobacterium tuberculosis and Mycobacterium smegmatis genomes reveals presence of an additional gyrB in M. smegmatis flanked by novel genes. Analysis of the amino acid sequence of GyrB from different organisms suggests that the orphan GyrB in M. smegmatis may have an important cellular role.

Original languageEnglish (US)
Pages (from-to)105-110
Number of pages6
JournalJournal of Genetics
Volume81
Issue number3
DOIs
StatePublished - Dec 2002

Keywords

  • Comparative genomics
  • DNA gyrase
  • Mycobacterium smegmatis
  • Topoisomerase
  • gyr genes

ASJC Scopus subject areas

  • Genetics

Fingerprint Dive into the research topics of 'An orphan gyrB in the Mycobacterium smegmatis genome uncovered by comparative genomics'. Together they form a unique fingerprint.

  • Cite this