An orphan gyrB in the Mycobacterium smegmatis genome uncovered by comparative genomics

P. Jain, V. Nagaraja

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

DNA gyrase is an essential topoisomerase found in all bacteria. It is encoded by gyrB and gyrA genes. These genes are organized differently in different bacteria. Direct comparison of Mycobacterium tuberculosis and Mycobacterium smegmatis genomes reveals presence of an additional gyrB in M. smegmatis flanked by novel genes. Analysis of the amino acid sequence of GyrB from different organisms suggests that the orphan GyrB in M. smegmatis may have an important cellular role.

Original languageEnglish (US)
Pages (from-to)105-110
Number of pages6
JournalJournal of Genetics
Volume81
Issue number3
StatePublished - Dec 2002
Externally publishedYes

Fingerprint

Mycobacterium smegmatis
Genomics
Genome
DNA Gyrase
Genes
Bacteria
Protein Sequence Analysis
Mycobacterium tuberculosis

Keywords

  • Comparative genomics
  • DNA gyrase
  • gyr genes
  • Mycobacterium smegmatis
  • Topoisomerase

ASJC Scopus subject areas

  • Genetics

Cite this

An orphan gyrB in the Mycobacterium smegmatis genome uncovered by comparative genomics. / Jain, P.; Nagaraja, V.

In: Journal of Genetics, Vol. 81, No. 3, 12.2002, p. 105-110.

Research output: Contribution to journalArticle

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