An orphan gyrB in the Mycobacterium smegmatis genome uncovered by comparative genomics

P. Jain; V. Nagaraja

doi:10.1007/BF02715907

An orphan gyrB in the Mycobacterium smegmatis genome uncovered by comparative genomics

P. Jain, V. Nagaraja

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

DNA gyrase is an essential topoisomerase found in all bacteria. It is encoded by gyrB and gyrA genes. These genes are organized differently in different bacteria. Direct comparison of Mycobacterium tuberculosis and Mycobacterium smegmatis genomes reveals presence of an additional gyrB in M. smegmatis flanked by novel genes. Analysis of the amino acid sequence of GyrB from different organisms suggests that the orphan GyrB in M. smegmatis may have an important cellular role.

Original language	English (US)
Pages (from-to)	105-110
Number of pages	6
Journal	Journal of Genetics
Volume	81
Issue number	3
DOIs	https://doi.org/10.1007/BF02715907
State	Published - Dec 2002
Externally published	Yes

Keywords

Comparative genomics
DNA gyrase
Mycobacterium smegmatis
Topoisomerase
gyr genes

ASJC Scopus subject areas

Genetics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/BF02715907

Cite this

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title = "An orphan gyrB in the Mycobacterium smegmatis genome uncovered by comparative genomics",

abstract = "DNA gyrase is an essential topoisomerase found in all bacteria. It is encoded by gyrB and gyrA genes. These genes are organized differently in different bacteria. Direct comparison of Mycobacterium tuberculosis and Mycobacterium smegmatis genomes reveals presence of an additional gyrB in M. smegmatis flanked by novel genes. Analysis of the amino acid sequence of GyrB from different organisms suggests that the orphan GyrB in M. smegmatis may have an important cellular role.",

keywords = "Comparative genomics, DNA gyrase, Mycobacterium smegmatis, Topoisomerase, gyr genes",

author = "P. Jain and V. Nagaraja",

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language = "English (US)",

volume = "81",

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AU - Jain, P.

AU - Nagaraja, V.

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AB - DNA gyrase is an essential topoisomerase found in all bacteria. It is encoded by gyrB and gyrA genes. These genes are organized differently in different bacteria. Direct comparison of Mycobacterium tuberculosis and Mycobacterium smegmatis genomes reveals presence of an additional gyrB in M. smegmatis flanked by novel genes. Analysis of the amino acid sequence of GyrB from different organisms suggests that the orphan GyrB in M. smegmatis may have an important cellular role.

KW - Comparative genomics

KW - DNA gyrase

KW - Mycobacterium smegmatis

KW - Topoisomerase

KW - gyr genes

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ER -

An orphan gyrB in the Mycobacterium smegmatis genome uncovered by comparative genomics

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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