An Open Resource for Non-human Primate Optogenetics

Sébastien Tremblay, Leah Acker, Arash Afraz, Daniel L. Albaugh, Hidetoshi Amita, Ariana R. Andrei, Alessandra Angelucci, Amir Aschner, Puiu F. Balan, Michele A. Basso, Giacomo Benvenuti, Martin O. Bohlen, Michael J. Caiola, Roberto Calcedo, James Cavanaugh, Yuzhi Chen, Spencer Chen, Mykyta M. Chernov, Andrew M. Clark, Ji DaiSamantha R. Debes, Karl Deisseroth, Robert Desimone, Valentin Dragoi, Seth W. Egger, Mark A.G. Eldridge, Hala G. El-Nahal, Francesco Fabbrini, Frederick Federer, Christopher R. Fetsch, Michal G. Fortuna, Robert M. Friedman, Naotaka Fujii, Alexander Gail, Adriana Galvan, Supriya Ghosh, Marc Alwin Gieselmann, Roberto A. Gulli, Okihide Hikosaka, Eghbal A. Hosseini, Xing Hu, Janina Hüer, Ken ichi Inoue, Roger Janz, Mehrdad Jazayeri, Rundong Jiang, Niansheng Ju, Kohitij Kar, Carsten Klein, Adam Kohn, Misako Komatsu, Kazutaka Maeda, Julio C. Martinez-Trujillo, Masayuki Matsumoto, John H.R. Maunsell, Diego Mendoza-Halliday, Ilya E. Monosov, Ross S. Muers, Lauri Nurminen, Michael Ortiz-Rios, Daniel J. O'Shea, Stéphane Palfi, Christopher I. Petkov, Sorin Pojoga, Rishi Rajalingham, Charu Ramakrishnan, Evan D. Remington, Cambria Revsine, Anna W. Roe, Philip N. Sabes, Richard C. Saunders, Hansjörg Scherberger, Michael C. Schmid, Wolfram Schultz, Eyal Seidemann, Yann Suhan Senova, Michael N. Shadlen, David L. Sheinberg, Caitlin Siu, Yoland Smith, Selina S. Solomon, Marc A. Sommer, John L. Spudich, William R. Stauffer, Masahiko Takada, Shiming Tang, Alexander Thiele, Stefan Treue, Wim Vanduffel, Rufin Vogels, Matthew P. Whitmire, Thomas Wichmann, Robert H. Wurtz, Haoran Xu, Azadeh Yazdan-Shahmorad, Krishna V. Shenoy, James J. DiCarlo, Michael L. Platt

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Optogenetics has revolutionized neuroscience in small laboratory animals, but its effect on animal models more closely related to humans, such as non-human primates (NHPs), has been mixed. To make evidence-based decisions in primate optogenetics, the scientific community would benefit from a centralized database listing all attempts, successful and unsuccessful, of using optogenetics in the primate brain. We contacted members of the community to ask for their contributions to an open science initiative. As of this writing, 45 laboratories around the world contributed more than 1,000 injection experiments, including precise details regarding their methods and outcomes. Of those entries, more than half had not been published. The resource is free for everyone to consult and contribute to on the Open Science Framework website. Here we review some of the insights from this initial release of the database and discuss methodological considerations to improve the success of optogenetic experiments in NHPs.

Original languageEnglish (US)
Pages (from-to)1075-1090.e6
JournalNeuron
Volume108
Issue number6
DOIs
StatePublished - Dec 23 2020

Keywords

  • Gene therapy
  • Monkey
  • Monkeys
  • Non-human primates
  • Nonhuman primates
  • Open Science
  • Optical control
  • Optogenetic
  • Optogenetics
  • Viral vectors

ASJC Scopus subject areas

  • Neuroscience(all)

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