An innate immune system cell is a major determinant of species-related susceptibility differences to fungal pneumonia

Xiuping Shao, Aron Mednick, Mauricio Alvarez, Nico Van Rooijen, Arturo Casadevall, David L. Goldman

Research output: Contribution to journalArticle

84 Citations (Scopus)

Abstract

Rats and mice are considered resistant and susceptible hosts, respectively, for experimental cryptococcosis. For both species, alveolar macrophages (AM) are central components of the host response to pulmonary Cryptococcus neoformans infection. We explored the role of AM in three strains of mice and three strains of rats during cryptococcal infection by comparing the outcome of infection after macrophage depletion using liposomal clodronate. AM depletion was associated with enhancement and amelioration of disease in rats and mice, respectively, as measured by lung fungal burden. The apparent protective role for AM in rats correlated with enhanced anticryptococcal activity as measured by phagocytic activity, oxidative burst, lysozyme secretion, and ability to limit intracellular growth of C. neoformans. Furthermore, rat AM were more resistant to lysis in association with intracellular infection. In summary, differences in AM function in rats and mice suggest an explanation for the species differences in susceptibility to C. neoformans based on the inherent efficacy of a central effector cell of the innate immune system.

Original languageEnglish (US)
Pages (from-to)3244-3251
Number of pages8
JournalJournal of Immunology
Volume175
Issue number5
StatePublished - Sep 1 2005

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Alveolar Macrophages
Immune System
Pneumonia
Cryptococcus neoformans
Infection
Clodronic Acid
Cryptococcosis
Lung
Respiratory Burst
Muramidase
Macrophages
Growth

ASJC Scopus subject areas

  • Immunology

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An innate immune system cell is a major determinant of species-related susceptibility differences to fungal pneumonia. / Shao, Xiuping; Mednick, Aron; Alvarez, Mauricio; Van Rooijen, Nico; Casadevall, Arturo; Goldman, David L.

In: Journal of Immunology, Vol. 175, No. 5, 01.09.2005, p. 3244-3251.

Research output: Contribution to journalArticle

Shao, X, Mednick, A, Alvarez, M, Van Rooijen, N, Casadevall, A & Goldman, DL 2005, 'An innate immune system cell is a major determinant of species-related susceptibility differences to fungal pneumonia', Journal of Immunology, vol. 175, no. 5, pp. 3244-3251.
Shao, Xiuping ; Mednick, Aron ; Alvarez, Mauricio ; Van Rooijen, Nico ; Casadevall, Arturo ; Goldman, David L. / An innate immune system cell is a major determinant of species-related susceptibility differences to fungal pneumonia. In: Journal of Immunology. 2005 ; Vol. 175, No. 5. pp. 3244-3251.
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