An inhibitory septum to lateral hypothalamus circuit that suppresses feeding

Patrick Sweeney, Yunlei Yang

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Feeding behavior is orchestrated by neural circuits primarily residing in the hypothalamus and hindbrain. However, the relative influence of cognitive and emotional brain circuits to the feeding circuitry in the hypothalamus and hindbrain remains unclear. Here, using the cell-type selectivity of genetic methods, circuit mapping, and behavior assays, we sought to decipher neural circuits emanating from the septal nucleus to the lateral hypothalamus (LH) that contribute to neural regulation of food intake in mice. We found that chemogenetic and optogenetic activation of septal vesicular GABA transporter (vGAT)-containing neurons or their projections in the LH reduced food intake in mice. Consistently, chemogenetic inhibition of septal vGAT neurons increased food intake. Furthermore, we investigated a previously unknown neural circuit originating from septal vGAT neurons to a subset of vGAT neurons in the LH, an area involved in homeostatic and hedonic control of energy states. Collectively, our data reveal an inhibitory septohypothalamic feeding circuit that might serve as a therapeutic target for the treatment of eating disorders such as anorexia nervosa.

Original languageEnglish (US)
Pages (from-to)11185-11195
Number of pages11
JournalJournal of Neuroscience
Volume36
Issue number44
DOIs
StatePublished - Nov 2 2016
Externally publishedYes

Fingerprint

Lateral Hypothalamic Area
GABAergic Neurons
Rhombencephalon
Hypothalamus
Eating
Optogenetics
Appetite Regulation
Septal Nuclei
Pleasure
Anorexia Nervosa
Feeding Behavior
Neurons
vesicular GABA transporter
Brain
Therapeutics

Keywords

  • Chemogenetics
  • Food intake
  • Lateral hypothalamus
  • Optogenetics
  • Septum

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

An inhibitory septum to lateral hypothalamus circuit that suppresses feeding. / Sweeney, Patrick; Yang, Yunlei.

In: Journal of Neuroscience, Vol. 36, No. 44, 02.11.2016, p. 11185-11195.

Research output: Contribution to journalArticle

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