An inexpensive drivable cannulated microelectrode array for simultaneous unit recording and drug infusion in the same brain nucleus of behaving rats

Johann du Hoffmann, James J. Kim, Saleem M. Nicola

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Neurons are functionally segregated into discrete populations that perform specific computations. These computations, mediated by neuron-neuron electrochemical signaling, form the neural basis of behavior. Thus fundamental to a brain-based understanding of behavior is the precise determination of the contribution made by specific neurotransmitters to behaviorally relevant neural activity. To facilitate this understanding, we have developed a cannulated microelectrode array for use in behaving rats that enables simultaneous neural ensemble recordings and local infusion of drugs in the same brain nucleus. The system is inexpensive, easy to use, and produces robust and quantitatively reproducible drug effects on recorded neurons. 2011 the American Physiological Society.

Original languageEnglish (US)
Pages (from-to)1054-1064
Number of pages11
JournalJournal of Neurophysiology
Volume106
Issue number2
DOIs
StatePublished - Aug 2011

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Microelectrodes
Neurons
Brain
Pharmaceutical Preparations
Neurotransmitter Agents
Population

Keywords

  • In vivo electrophysiology
  • Intracranial microinjections
  • Pharmacology

ASJC Scopus subject areas

  • Physiology
  • Neuroscience(all)

Cite this

An inexpensive drivable cannulated microelectrode array for simultaneous unit recording and drug infusion in the same brain nucleus of behaving rats. / du Hoffmann, Johann; Kim, James J.; Nicola, Saleem M.

In: Journal of Neurophysiology, Vol. 106, No. 2, 08.2011, p. 1054-1064.

Research output: Contribution to journalArticle

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