An implantable 64-channel neural interface with reconfigurable recording and stimulation

Jesse J. Wheeler, Keith Baldwin, Alex Kindle, Daniel Guyon, Brian Nugent, Carlos Segura, John Rodriguez, Andrew Czarnecki, Hailey J. Dispirito, John Lachapelle, Philip D. Parks, James Moran, Alik S. Widge, Darin D. Dougherty, Emad N. Eskandar

Research output: Chapter in Book/Report/Conference proceedingConference contribution

15 Citations (Scopus)

Abstract

Next generation implantable medical devices will have the potential to provide more precise and effective therapies through adaptive closed-loop controllers that combine sensing and stimulation across larger numbers of electrode channels. A major challenge in the design of such devices is balancing increased functionality and channel counts with the miniaturization required for implantation within small anatomical spaces. Customized therapies will require adaptive systems capable of tuning which channels are sensed and stimulated to overcome variability in patient-specific needs, surgical placement of electrodes, and chronic physiological responses. In order to address these challenges, we have designed a miniaturized implantable fully-reconfigurable front-end system that is integrated into the distal end of an 8-wire lead, enabling up to 64 electrodes to be dynamically configured for sensing and stimulation. Full reconfigurability is enabled by two custom 32×2 cross-point switch (CPS) matrix ASICs which can route any electrode to either an amplifier with reprogrammable bandwidth and integrated ADC or to one of two independent stimulation channels that can be driven through the lead. The 8-wire circuit includes a digital interface for robust communication as well as a charge-balanced powering scheme for enhanced safety. The system is encased in a hermetic package designed to fit within a 14 mm bur-hole in the skull for neuromodulation of the brain, but could easily be adapted to enhance therapies across a broad spectrum of applications.

Original languageEnglish (US)
Title of host publication2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages7837-7840
Number of pages4
Volume2015-November
ISBN (Electronic)9781424492718
DOIs
StatePublished - Nov 4 2015
Externally publishedYes
Event37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015 - Milan, Italy
Duration: Aug 25 2015Aug 29 2015

Other

Other37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015
CountryItaly
CityMilan
Period8/25/158/29/15

Fingerprint

Electrodes
Lead
Wire
Miniaturization
Equipment Design
Adaptive systems
Application specific integrated circuits
Skull
Brain
Therapeutics
Tuning
Communication
Switches
Bandwidth
Safety
Equipment and Supplies
Controllers
Networks (circuits)

Keywords

  • Neural interfaces - Implantable systems
  • Neural interfaces - Microsystems and microfabrication
  • Neural stimulation - Deep brain

ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

Cite this

Wheeler, J. J., Baldwin, K., Kindle, A., Guyon, D., Nugent, B., Segura, C., ... Eskandar, E. N. (2015). An implantable 64-channel neural interface with reconfigurable recording and stimulation. In 2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015 (Vol. 2015-November, pp. 7837-7840). [7320208] Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/EMBC.2015.7320208

An implantable 64-channel neural interface with reconfigurable recording and stimulation. / Wheeler, Jesse J.; Baldwin, Keith; Kindle, Alex; Guyon, Daniel; Nugent, Brian; Segura, Carlos; Rodriguez, John; Czarnecki, Andrew; Dispirito, Hailey J.; Lachapelle, John; Parks, Philip D.; Moran, James; Widge, Alik S.; Dougherty, Darin D.; Eskandar, Emad N.

2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015. Vol. 2015-November Institute of Electrical and Electronics Engineers Inc., 2015. p. 7837-7840 7320208.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Wheeler, JJ, Baldwin, K, Kindle, A, Guyon, D, Nugent, B, Segura, C, Rodriguez, J, Czarnecki, A, Dispirito, HJ, Lachapelle, J, Parks, PD, Moran, J, Widge, AS, Dougherty, DD & Eskandar, EN 2015, An implantable 64-channel neural interface with reconfigurable recording and stimulation. in 2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015. vol. 2015-November, 7320208, Institute of Electrical and Electronics Engineers Inc., pp. 7837-7840, 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015, Milan, Italy, 8/25/15. https://doi.org/10.1109/EMBC.2015.7320208
Wheeler JJ, Baldwin K, Kindle A, Guyon D, Nugent B, Segura C et al. An implantable 64-channel neural interface with reconfigurable recording and stimulation. In 2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015. Vol. 2015-November. Institute of Electrical and Electronics Engineers Inc. 2015. p. 7837-7840. 7320208 https://doi.org/10.1109/EMBC.2015.7320208
Wheeler, Jesse J. ; Baldwin, Keith ; Kindle, Alex ; Guyon, Daniel ; Nugent, Brian ; Segura, Carlos ; Rodriguez, John ; Czarnecki, Andrew ; Dispirito, Hailey J. ; Lachapelle, John ; Parks, Philip D. ; Moran, James ; Widge, Alik S. ; Dougherty, Darin D. ; Eskandar, Emad N. / An implantable 64-channel neural interface with reconfigurable recording and stimulation. 2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015. Vol. 2015-November Institute of Electrical and Electronics Engineers Inc., 2015. pp. 7837-7840
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