TY - JOUR
T1 - An Evolutionary Approach to Clonally Complex Hematologic Disorders
AU - Schwenger, Emily
AU - Steidl, Ulrich
N1 - Publisher Copyright:
©2021 American Association for Cancer Research.
PY - 2021/5/1
Y1 - 2021/5/1
N2 - Emerging clonal complexity has brought into question the way in which we perceive and, in turn, treat disorders of the hematopoietic system. Former models of cell-intrinsic clonal dominance driven by acquisition of driver genes in a stereotypic sequence are often insufficient in explaining observations such as clonal hematopoiesis, and new paradigms are in order. Here, we review the evidence within the hematologic malignancy field and also borrow from perspectives rooted in evolutionary biology to reframe pathogenesis of hematologic disorders as dynamic processes involving complex interplays of genetic and nongenetic subclones and the tissue microenvironment in which they reside.
AB - Emerging clonal complexity has brought into question the way in which we perceive and, in turn, treat disorders of the hematopoietic system. Former models of cell-intrinsic clonal dominance driven by acquisition of driver genes in a stereotypic sequence are often insufficient in explaining observations such as clonal hematopoiesis, and new paradigms are in order. Here, we review the evidence within the hematologic malignancy field and also borrow from perspectives rooted in evolutionary biology to reframe pathogenesis of hematologic disorders as dynamic processes involving complex interplays of genetic and nongenetic subclones and the tissue microenvironment in which they reside.
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U2 - 10.1158/2643-3230.BCD-20-0219
DO - 10.1158/2643-3230.BCD-20-0219
M3 - Review article
C2 - 34027415
AN - SCOPUS:85129991948
SN - 2643-3230
VL - 2
SP - 201
EP - 215
JO - Blood cancer discovery
JF - Blood cancer discovery
IS - 3
ER -