An evaluation by midwives and gynecologists of treatability of cervical lesions by cryotherapy among human papillomavirus-positive women

Julia C. Gage, Ana Cecilia Rodriguez, Mark Schiffman, Sydney Adadevoh, Manuel J Alvarez Larraondo, Bandit Chumworathayi, Sandra Vargas Lejarza, Luis Villegas Araya, Francisco Garcia, Scott R. Budihas, Rodney Long, Hormuzd A. Katki, Rolando Herrero, Robert D. Burk, Jose Jeronimo

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Objectives: To estimate efficacy of a visual triage of human papillomavirus (HPV)-positive women to either immediate cryotherapy or referral if not treatable (eg, invasive cancer, large precancers). Methods: We evaluated visual triage in the HPV-positive women aged 25 to 55 years from the 10,000-woman Guanacaste Cohort Study (n = 552). Twelve Peruvian midwives and 5 international gynecologists assessed treatability by cryotherapy using digitized highresolution cervical images taken at enrollment. The reference standard of treatability was determined by 2 lead gynecologists from the entire 7-year follow-up of the women. Women diagnosed with histologic cervical intraepithelial neoplasia grade 2 or worse or 5-year persistence of carcinogenic HPV infection were defined as needing treatment. Results: Midwives and gynecologists judged 30.8% and 41.2% of women not treatable by cryotherapy, respectively (P G 0.01). Among 149 women needing treatment, midwives and gynecologists correctly identified 57.5% and 63.8% (P = 0.07 for difference) of 71 women judged not treatable by the lead gynecologists and 77.6% and 59.7% (P G 0.01 for difference) of 78 women judged treatable by cryotherapy. The proportion of women judged not treatable by a reviewer varied widely and ranged from 18.6%to 61.1%. Interrater agreement was poor with mean pairwise overall agreement of 71.4% and 66.3% and J's of 0.33 and 0.30 for midwives and gynecologists, respectively. Conclusions: In future Bscreen-and-treat cervical cancer prevention programs using HPV testing and cryotherapy, practitioners will visually triage HPV-positive women. The suboptimal performance of visual triage suggests that screen-and-treat programs using cryotherapy might be insufficient for treating precancerous lesions. Improved, low-technology triage methods and/or improved safe and low-technology treatment options are needed.

Original languageEnglish (US)
Pages (from-to)728-733
Number of pages6
JournalInternational Journal of Gynecological Cancer
Volume19
Issue number4
DOIs
StatePublished - May 2009

Fingerprint

Cryotherapy
Midwifery
Triage
Technology
Cervical Intraepithelial Neoplasia
Papillomavirus Infections
Uterine Cervical Neoplasms
Cohort Studies
Therapeutics
Referral and Consultation

Keywords

  • Cervical intraepithelial neoplasia
  • Cryotherapy
  • Human papillomavirus
  • Low-resource settings
  • Screen-and-treat

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Oncology

Cite this

An evaluation by midwives and gynecologists of treatability of cervical lesions by cryotherapy among human papillomavirus-positive women. / Gage, Julia C.; Rodriguez, Ana Cecilia; Schiffman, Mark; Adadevoh, Sydney; Larraondo, Manuel J Alvarez; Chumworathayi, Bandit; Lejarza, Sandra Vargas; Araya, Luis Villegas; Garcia, Francisco; Budihas, Scott R.; Long, Rodney; Katki, Hormuzd A.; Herrero, Rolando; Burk, Robert D.; Jeronimo, Jose.

In: International Journal of Gynecological Cancer, Vol. 19, No. 4, 05.2009, p. 728-733.

Research output: Contribution to journalArticle

Gage, JC, Rodriguez, AC, Schiffman, M, Adadevoh, S, Larraondo, MJA, Chumworathayi, B, Lejarza, SV, Araya, LV, Garcia, F, Budihas, SR, Long, R, Katki, HA, Herrero, R, Burk, RD & Jeronimo, J 2009, 'An evaluation by midwives and gynecologists of treatability of cervical lesions by cryotherapy among human papillomavirus-positive women', International Journal of Gynecological Cancer, vol. 19, no. 4, pp. 728-733. https://doi.org/10.1111/IGC.0b013e3181a48b99
Gage, Julia C. ; Rodriguez, Ana Cecilia ; Schiffman, Mark ; Adadevoh, Sydney ; Larraondo, Manuel J Alvarez ; Chumworathayi, Bandit ; Lejarza, Sandra Vargas ; Araya, Luis Villegas ; Garcia, Francisco ; Budihas, Scott R. ; Long, Rodney ; Katki, Hormuzd A. ; Herrero, Rolando ; Burk, Robert D. ; Jeronimo, Jose. / An evaluation by midwives and gynecologists of treatability of cervical lesions by cryotherapy among human papillomavirus-positive women. In: International Journal of Gynecological Cancer. 2009 ; Vol. 19, No. 4. pp. 728-733.
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abstract = "Objectives: To estimate efficacy of a visual triage of human papillomavirus (HPV)-positive women to either immediate cryotherapy or referral if not treatable (eg, invasive cancer, large precancers). Methods: We evaluated visual triage in the HPV-positive women aged 25 to 55 years from the 10,000-woman Guanacaste Cohort Study (n = 552). Twelve Peruvian midwives and 5 international gynecologists assessed treatability by cryotherapy using digitized highresolution cervical images taken at enrollment. The reference standard of treatability was determined by 2 lead gynecologists from the entire 7-year follow-up of the women. Women diagnosed with histologic cervical intraepithelial neoplasia grade 2 or worse or 5-year persistence of carcinogenic HPV infection were defined as needing treatment. Results: Midwives and gynecologists judged 30.8{\%} and 41.2{\%} of women not treatable by cryotherapy, respectively (P G 0.01). Among 149 women needing treatment, midwives and gynecologists correctly identified 57.5{\%} and 63.8{\%} (P = 0.07 for difference) of 71 women judged not treatable by the lead gynecologists and 77.6{\%} and 59.7{\%} (P G 0.01 for difference) of 78 women judged treatable by cryotherapy. The proportion of women judged not treatable by a reviewer varied widely and ranged from 18.6{\%}to 61.1{\%}. Interrater agreement was poor with mean pairwise overall agreement of 71.4{\%} and 66.3{\%} and J's of 0.33 and 0.30 for midwives and gynecologists, respectively. Conclusions: In future Bscreen-and-treat cervical cancer prevention programs using HPV testing and cryotherapy, practitioners will visually triage HPV-positive women. The suboptimal performance of visual triage suggests that screen-and-treat programs using cryotherapy might be insufficient for treating precancerous lesions. Improved, low-technology triage methods and/or improved safe and low-technology treatment options are needed.",
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AU - Adadevoh, Sydney

AU - Larraondo, Manuel J Alvarez

AU - Chumworathayi, Bandit

AU - Lejarza, Sandra Vargas

AU - Araya, Luis Villegas

AU - Garcia, Francisco

AU - Budihas, Scott R.

AU - Long, Rodney

AU - Katki, Hormuzd A.

AU - Herrero, Rolando

AU - Burk, Robert D.

AU - Jeronimo, Jose

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N2 - Objectives: To estimate efficacy of a visual triage of human papillomavirus (HPV)-positive women to either immediate cryotherapy or referral if not treatable (eg, invasive cancer, large precancers). Methods: We evaluated visual triage in the HPV-positive women aged 25 to 55 years from the 10,000-woman Guanacaste Cohort Study (n = 552). Twelve Peruvian midwives and 5 international gynecologists assessed treatability by cryotherapy using digitized highresolution cervical images taken at enrollment. The reference standard of treatability was determined by 2 lead gynecologists from the entire 7-year follow-up of the women. Women diagnosed with histologic cervical intraepithelial neoplasia grade 2 or worse or 5-year persistence of carcinogenic HPV infection were defined as needing treatment. Results: Midwives and gynecologists judged 30.8% and 41.2% of women not treatable by cryotherapy, respectively (P G 0.01). Among 149 women needing treatment, midwives and gynecologists correctly identified 57.5% and 63.8% (P = 0.07 for difference) of 71 women judged not treatable by the lead gynecologists and 77.6% and 59.7% (P G 0.01 for difference) of 78 women judged treatable by cryotherapy. The proportion of women judged not treatable by a reviewer varied widely and ranged from 18.6%to 61.1%. Interrater agreement was poor with mean pairwise overall agreement of 71.4% and 66.3% and J's of 0.33 and 0.30 for midwives and gynecologists, respectively. Conclusions: In future Bscreen-and-treat cervical cancer prevention programs using HPV testing and cryotherapy, practitioners will visually triage HPV-positive women. The suboptimal performance of visual triage suggests that screen-and-treat programs using cryotherapy might be insufficient for treating precancerous lesions. Improved, low-technology triage methods and/or improved safe and low-technology treatment options are needed.

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