An emerging role for cytopathology in precision oncology

Chantal Pauli; Loredana Puca; Juan Miguel Mosquera; Brian D. Robinson; Himisha Beltran; Mark A. Rubin; Rema A. Rao

doi:10.1002/cncy.21647

An emerging role for cytopathology in precision oncology

Chantal Pauli, Loredana Puca, Juan Miguel Mosquera, Brian D. Robinson, Himisha Beltran, Mark A. Rubin, Rema A. Rao

Research output: Contribution to journal › Review article › peer-review

20 Scopus citations

Abstract

Precision medicine is an emerging field in medicine for disease prevention and treatment that takes into account the individual variability in genes, environment, and lifestyle for each individual patient. The authors have developed a special program as part of the Englander Institute for Precision Medicine to grow patient-derived, 3-dimensional tumor organoids for tumor-specific drug testing, tailoring treatment strategies, and as models for studying drug resistance. Routine cytology preparations represent a cost-effective and powerful tool to aid in performing molecular testing in the age of personalized medicine. In this commentary, the platforms used for the characterization and validation of patient-derived, 3-dimensional tumor organoids are outlined and discussed, and the role of cytology as a cost-effective and powerful quality-control measure is illustrated.

Original language	English (US)
Pages (from-to)	167-173
Number of pages	7
Journal	Cancer Cytopathology
Volume	124
Issue number	3
DOIs	https://doi.org/10.1002/cncy.21647
State	Published - Mar 1 2016
Externally published	Yes

Keywords

3-dimensional (3D) tumor organoid
cytology
cytology smear
in vitro models
next-generation sequencing
organoids
precision medicine

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/cncy.21647

Cite this

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title = "An emerging role for cytopathology in precision oncology",

abstract = "Precision medicine is an emerging field in medicine for disease prevention and treatment that takes into account the individual variability in genes, environment, and lifestyle for each individual patient. The authors have developed a special program as part of the Englander Institute for Precision Medicine to grow patient-derived, 3-dimensional tumor organoids for tumor-specific drug testing, tailoring treatment strategies, and as models for studying drug resistance. Routine cytology preparations represent a cost-effective and powerful tool to aid in performing molecular testing in the age of personalized medicine. In this commentary, the platforms used for the characterization and validation of patient-derived, 3-dimensional tumor organoids are outlined and discussed, and the role of cytology as a cost-effective and powerful quality-control measure is illustrated.",

keywords = "3-dimensional (3D) tumor organoid, cytology, cytology smear, in vitro models, next-generation sequencing, organoids, precision medicine",

author = "Chantal Pauli and Loredana Puca and Mosquera, {Juan Miguel} and Robinson, {Brian D.} and Himisha Beltran and Rubin, {Mark A.} and Rao, {Rema A.}",

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AU - Robinson, Brian D.

AU - Beltran, Himisha

AU - Rubin, Mark A.

AU - Rao, Rema A.

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An emerging role for cytopathology in precision oncology

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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