An antimicrobial activity of cytolytic T cells mediated by granulysin

Steffen Stenger, Dennis A. Hanson, Rachel Teitelbaum, Puneet Dewan, Kayvan R. Niazi, Christopher J. Froelich, Tomas Ganz, Sybille Thoma-Uszynski, Agustín Melián, Christian Bogdan, Steven A. Porcelli, Barry R. Bloom, Alan M. Krensky, Robert L. Modlin

Research output: Contribution to journalArticle

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Abstract

Cytolytic T lymphocytes (CTLs) kill intracellular pathogens by a granule-dependent mechanism. Granulysin, a protein found in granules of CTLs, reduced the viability of a broad spectrum of pathogenic bacteria, fungi, and parasites in vitro. Granulysin directly killed extracellular Mycobacterium tuberculosis, altering the membrane integrity of the bacillus, and, in combination with perforin, decreased the viability of intracellular M. tuberculosis. The ability of CTLs to kill intracellular M. tuberculosis was dependent on the presence of granulysin in cytotoxic granules, defining a mechanism by which T cells directly contribute to immunity against intracellular pathogens.

Original languageEnglish (US)
Pages (from-to)121-125
Number of pages5
JournalScience
Volume282
Issue number5386
DOIs
StatePublished - Oct 2 1998
Externally publishedYes

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Mycobacterium tuberculosis
T-Lymphocytes
Perforin
Bacillus
Immunity
Parasites
Fungi
Bacteria
Membranes
Proteins

ASJC Scopus subject areas

  • General

Cite this

Stenger, S., Hanson, D. A., Teitelbaum, R., Dewan, P., Niazi, K. R., Froelich, C. J., ... Modlin, R. L. (1998). An antimicrobial activity of cytolytic T cells mediated by granulysin. Science, 282(5386), 121-125. https://doi.org/10.1126/science.282.5386.121

An antimicrobial activity of cytolytic T cells mediated by granulysin. / Stenger, Steffen; Hanson, Dennis A.; Teitelbaum, Rachel; Dewan, Puneet; Niazi, Kayvan R.; Froelich, Christopher J.; Ganz, Tomas; Thoma-Uszynski, Sybille; Melián, Agustín; Bogdan, Christian; Porcelli, Steven A.; Bloom, Barry R.; Krensky, Alan M.; Modlin, Robert L.

In: Science, Vol. 282, No. 5386, 02.10.1998, p. 121-125.

Research output: Contribution to journalArticle

Stenger, S, Hanson, DA, Teitelbaum, R, Dewan, P, Niazi, KR, Froelich, CJ, Ganz, T, Thoma-Uszynski, S, Melián, A, Bogdan, C, Porcelli, SA, Bloom, BR, Krensky, AM & Modlin, RL 1998, 'An antimicrobial activity of cytolytic T cells mediated by granulysin', Science, vol. 282, no. 5386, pp. 121-125. https://doi.org/10.1126/science.282.5386.121
Stenger S, Hanson DA, Teitelbaum R, Dewan P, Niazi KR, Froelich CJ et al. An antimicrobial activity of cytolytic T cells mediated by granulysin. Science. 1998 Oct 2;282(5386):121-125. https://doi.org/10.1126/science.282.5386.121
Stenger, Steffen ; Hanson, Dennis A. ; Teitelbaum, Rachel ; Dewan, Puneet ; Niazi, Kayvan R. ; Froelich, Christopher J. ; Ganz, Tomas ; Thoma-Uszynski, Sybille ; Melián, Agustín ; Bogdan, Christian ; Porcelli, Steven A. ; Bloom, Barry R. ; Krensky, Alan M. ; Modlin, Robert L. / An antimicrobial activity of cytolytic T cells mediated by granulysin. In: Science. 1998 ; Vol. 282, No. 5386. pp. 121-125.
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