An antimicrobial activity of cytolytic T cells mediated by granulysin

Steffen Stenger, Dennis A. Hanson, Rachel Teitelbaum, Puneet Dewan, Kayvan R. Niazi, Christopher J. Froelich, Tomas Ganz, Sybille Thoma-Uszynski, Agustín Melián, Christian Bogdan, Steven A. Porcelli, Barry R. Bloom, Alan M. Krensky, Robert L. Modlin

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812 Scopus citations

Abstract

Cytolytic T lymphocytes (CTLs) kill intracellular pathogens by a granule-dependent mechanism. Granulysin, a protein found in granules of CTLs, reduced the viability of a broad spectrum of pathogenic bacteria, fungi, and parasites in vitro. Granulysin directly killed extracellular Mycobacterium tuberculosis, altering the membrane integrity of the bacillus, and, in combination with perforin, decreased the viability of intracellular M. tuberculosis. The ability of CTLs to kill intracellular M. tuberculosis was dependent on the presence of granulysin in cytotoxic granules, defining a mechanism by which T cells directly contribute to immunity against intracellular pathogens.

Original languageEnglish (US)
Pages (from-to)121-125
Number of pages5
JournalScience
Volume282
Issue number5386
DOIs
StatePublished - Oct 2 1998
Externally publishedYes

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    Stenger, S., Hanson, D. A., Teitelbaum, R., Dewan, P., Niazi, K. R., Froelich, C. J., Ganz, T., Thoma-Uszynski, S., Melián, A., Bogdan, C., Porcelli, S. A., Bloom, B. R., Krensky, A. M., & Modlin, R. L. (1998). An antimicrobial activity of cytolytic T cells mediated by granulysin. Science, 282(5386), 121-125. https://doi.org/10.1126/science.282.5386.121