Amyotrophic lateral sclerosis and parkinsonism-dementia complex on Guam: immunohistochemical studies.

A. Hirano

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

The incidence of amyotrophic lateral sclerosis (ALS) and Parkinsonism-dementia complex (PDC) among the Chamorros in Guam is remarkably high. The patients with ALS have clinical and pathological characteristics similar to those in other parts of the world. The PDC patients display parkinsonism and progressive dementia and show a characteristic neuronal loss in certain parts of the central nervous system such as the hippocampus and substantia nigra. The Guamanian patients with ALS and PDC commonly have widespread Alzheimer's neurofibrillary changes, but without the associated senile plaques. We have applied immunohistochemical procedures to examine the expression of marker substances in Guamanian ALS and PDC. The markers studied include tau protein, ubiquitin, beta proteins, synaptophysin, calcineurin, Met-enkephalin, substance P and tyrosine hydroxylase. The results were compared with the findings in patients with Alzheimer's disease, Parkinson's disease, sporadic ALS and familial ALS.

Original languageEnglish (US)
Pages (from-to)6-9
Number of pages4
JournalKeio Journal of Medicine
Volume41
Issue number1
StatePublished - Mar 1992

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Amyotrophic Lateral Sclerosis
Parkinsonian Disorders
Dementia
Guam
tau Proteins
Methionine Enkephalin
Synaptophysin
Calcineurin
Amyloid Plaques
Tyrosine 3-Monooxygenase
Substantia Nigra
Substance P
Ubiquitin
Parkinson Disease
Hippocampus
Alzheimer Disease
Central Nervous System
Incidence
Proteins
Amyotrophic lateral sclerosis 1

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Amyotrophic lateral sclerosis and parkinsonism-dementia complex on Guam : immunohistochemical studies. / Hirano, A.

In: Keio Journal of Medicine, Vol. 41, No. 1, 03.1992, p. 6-9.

Research output: Contribution to journalArticle

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