Amyloid-β alters ongoing neuronal activity and excitability in the frontal cortex

Vered Kellner, Noa Menkes-Caspi, Shlomit Beker, Edward A. Stern

Research output: Contribution to journalArticlepeer-review

26 Scopus citations


The effects of amyloid-β on the activity and excitability of individual neurons in the early and advanced stages of the pathological progression of Alzheimer's disease remain unknown. We used invivo intracellular recordings to measure the ongoing and evoked activity of pyramidal neurons in the frontal cortex of APPswe/PS1dE9 transgenic mice and age-matched nontransgenic littermate controls. Evoked excitability was altered in both transgenic groups: neurons in young transgenic mice displayed hypoexcitability, whereas those in older transgenic mice displayed hyperexcitability, suggesting changes in intrinsic electrical properties of the neurons. However, the ongoing activity of neurons in both young and old transgenic groups showed signs of hyperexcitability in the depolarized state of the membrane potential. The membrane potential of neurons in old transgenic mice had an increased tendency to fail to transition to the depolarized state, and the depolarized states had shorter durations on average than did controls. This suggests a combination of both intrinsic electrical and synaptic dysfunctions as mechanisms for activity changes at later stages of the neuropathological progression.

Original languageEnglish (US)
Pages (from-to)1982-1991
Number of pages10
JournalNeurobiology of Aging
Issue number9
StatePublished - Sep 2014
Externally publishedYes


  • APPswe/PS1dE9
  • Alzheimer's disease
  • Background activity
  • Down state
  • Hyperexcitability
  • Invivo
  • Membrane potential
  • Mouse model
  • Up state

ASJC Scopus subject areas

  • Neuroscience(all)
  • Aging
  • Developmental Biology
  • Clinical Neurology
  • Geriatrics and Gerontology


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