Amplified C(λ) and c-abl genes are on the same marker chromosome in K562 leukemia cells

J. R. Selden, B. S. Emanuel, E. Wang, L. Cannizzaro, A. Palumbo, J. Erikson, P. C. Nowell, G. Rovera, C. M. Croce

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

The human leukemia cell line K562, derived from a patient with Philadelphia chromosome-positive chronic myelogenous leukemia, contains amplified c-abl oncogenes and unrearranged C(λ) genes. Using in situ hybridization techniques, we have determined that the amplified c-abl and C(λ) DNA sequences of K562 cells are both located on the same abnormal acrocentric marker chromosome, which may represent an altered Philadelphia chromosome.

Original languageEnglish (US)
Pages (from-to)7289-7292
Number of pages4
JournalProceedings of the National Academy of Sciences of the United States of America
Volume80
Issue number23 I
StatePublished - 1983
Externally publishedYes

Fingerprint

abl Genes
Philadelphia Chromosome
K562 Cells
Genetic Markers
Leukemia
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
In Situ Hybridization
Cell Line
Genes

ASJC Scopus subject areas

  • Genetics
  • General

Cite this

Selden, J. R., Emanuel, B. S., Wang, E., Cannizzaro, L., Palumbo, A., Erikson, J., ... Croce, C. M. (1983). Amplified C(λ) and c-abl genes are on the same marker chromosome in K562 leukemia cells. Proceedings of the National Academy of Sciences of the United States of America, 80(23 I), 7289-7292.

Amplified C(λ) and c-abl genes are on the same marker chromosome in K562 leukemia cells. / Selden, J. R.; Emanuel, B. S.; Wang, E.; Cannizzaro, L.; Palumbo, A.; Erikson, J.; Nowell, P. C.; Rovera, G.; Croce, C. M.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 80, No. 23 I, 1983, p. 7289-7292.

Research output: Contribution to journalArticle

Selden, JR, Emanuel, BS, Wang, E, Cannizzaro, L, Palumbo, A, Erikson, J, Nowell, PC, Rovera, G & Croce, CM 1983, 'Amplified C(λ) and c-abl genes are on the same marker chromosome in K562 leukemia cells', Proceedings of the National Academy of Sciences of the United States of America, vol. 80, no. 23 I, pp. 7289-7292.
Selden, J. R. ; Emanuel, B. S. ; Wang, E. ; Cannizzaro, L. ; Palumbo, A. ; Erikson, J. ; Nowell, P. C. ; Rovera, G. ; Croce, C. M. / Amplified C(λ) and c-abl genes are on the same marker chromosome in K562 leukemia cells. In: Proceedings of the National Academy of Sciences of the United States of America. 1983 ; Vol. 80, No. 23 I. pp. 7289-7292.
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