Amplified C(λ) and c-abl genes are on the same marker chromosome in K562 leukemia cells

J. R. Selden, B. S. Emanuel, E. Wang, L. Cannizzaro, A. Palumbo, J. Erikson, P. C. Nowell, G. Rovera, C. M. Croce

Research output: Contribution to journalArticlepeer-review

63 Scopus citations

Abstract

The human leukemia cell line K562, derived from a patient with Philadelphia chromosome-positive chronic myelogenous leukemia, contains amplified c-abl oncogenes and unrearranged C(λ) genes. Using in situ hybridization techniques, we have determined that the amplified c-abl and C(λ) DNA sequences of K562 cells are both located on the same abnormal acrocentric marker chromosome, which may represent an altered Philadelphia chromosome.

Original languageEnglish (US)
Pages (from-to)7289-7292
Number of pages4
JournalProceedings of the National Academy of Sciences of the United States of America
Volume80
Issue number23 I
DOIs
StatePublished - 1983

ASJC Scopus subject areas

  • General

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