Amoxicillin-clavulanate therapy increases childhood nasal colonization by methicillin-susceptible Staphylococcus aureus strains producing high levels of penicillinase

Didier Guillemot, Stephane Bonacorsi, John S. Blanchard, Philippe Weber, Sylvie Simon, Bruno Guesnon, Edouard Bingen, Claude Carbon

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

We examined factors associated with penicillinase production by nasal carriage Staphylococcus aureus strains in 648 children aged 3 to 6 years attending 20 randomly sampled playschools. The children were prospectively monitored for drug use and medical events for 6 months and were then screened for S. aureus carriage. Isolates were tested for their susceptibility to penicillin G and methicillin, and penicillinase production by methicillin-susceptible, penicillin-resistant strains was quantified. S. aureus was isolated from 166 children (25.6%). Exposure to amoxicillin-clavulanate during the previous 3 months was associated with higher penicillinase production by penicillin-resistant, methicillin-susceptible strains (odds ratio, 3.6; F = 0.03). These results suggest that use of the amoxicillin-clavulanate combination could induce a herd selection process of S. aureus strains producing higher levels of penicillinase.

Original languageEnglish (US)
Pages (from-to)4618-4623
Number of pages6
JournalAntimicrobial Agents and Chemotherapy
Volume48
Issue number12
DOIs
StatePublished - Dec 2004

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Penicillinase
Clavulanic Acid
Methicillin
Amoxicillin
Nose
Staphylococcus aureus
Penicillins
Methicillin Resistance
Penicillin G
Therapeutics
Odds Ratio
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

Amoxicillin-clavulanate therapy increases childhood nasal colonization by methicillin-susceptible Staphylococcus aureus strains producing high levels of penicillinase. / Guillemot, Didier; Bonacorsi, Stephane; Blanchard, John S.; Weber, Philippe; Simon, Sylvie; Guesnon, Bruno; Bingen, Edouard; Carbon, Claude.

In: Antimicrobial Agents and Chemotherapy, Vol. 48, No. 12, 12.2004, p. 4618-4623.

Research output: Contribution to journalArticle

Guillemot, Didier ; Bonacorsi, Stephane ; Blanchard, John S. ; Weber, Philippe ; Simon, Sylvie ; Guesnon, Bruno ; Bingen, Edouard ; Carbon, Claude. / Amoxicillin-clavulanate therapy increases childhood nasal colonization by methicillin-susceptible Staphylococcus aureus strains producing high levels of penicillinase. In: Antimicrobial Agents and Chemotherapy. 2004 ; Vol. 48, No. 12. pp. 4618-4623.
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