Amoxicillin-clavulanate therapy increases childhood nasal colonization by methicillin-susceptible Staphylococcus aureus strains producing high levels of penicillinase

Didier Guillemot, Stephane Bonacorsi, John S. Blanchard, Philippe Weber, Sylvie Simon, Bruno Guesnon, Edouard Bingen, Claude Carbon

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

We examined factors associated with penicillinase production by nasal carriage Staphylococcus aureus strains in 648 children aged 3 to 6 years attending 20 randomly sampled playschools. The children were prospectively monitored for drug use and medical events for 6 months and were then screened for S. aureus carriage. Isolates were tested for their susceptibility to penicillin G and methicillin, and penicillinase production by methicillin-susceptible, penicillin-resistant strains was quantified. S. aureus was isolated from 166 children (25.6%). Exposure to amoxicillin-clavulanate during the previous 3 months was associated with higher penicillinase production by penicillin-resistant, methicillin-susceptible strains (odds ratio, 3.6; F = 0.03). These results suggest that use of the amoxicillin-clavulanate combination could induce a herd selection process of S. aureus strains producing higher levels of penicillinase.

Original languageEnglish (US)
Pages (from-to)4618-4623
Number of pages6
JournalAntimicrobial agents and chemotherapy
Volume48
Issue number12
DOIs
StatePublished - Dec 2004

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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