Abstract
OBJECTIVE: Our aim was to examine changes from normal in the composition of amniotic fluid in fetal lambs with mild and severe hypoxemia and intrauterine growth restriction. STUDY DESIGN: Pregnant sheep underwent maternal catheterization at 88 to 93 days' gestation and fetal catheterization at 105-112 days' gestation. Twelve pregnancies (group 1) provided control data (fetal PaO2 18-22 mm Hg), in 12 fetuses (group 2) mild hypoxemia (PaO2 16-19 mm Hg) was induced by prevention of the normal expansion of maternal blood volume, and in 7 fetuses (group 3) chronic hypoxemia (PaO2 12-18 mm Hg) developed spontaneously. RESULTS: In group 2 amniotic fluid osmolality and sodium concentrations were lower (approximately 30 mOsm/kg and 10 mEq/L, P < .05) and urea nitrogen level was higher (10 mg/dL, P < .05) than in group 1, in group 3 osmolality and sodium concentrations at approximately 120 days' gestation were similar to those in group 1. Whereas these values decreased with gestation n groups 1 and 2 (P < .05), they remained unchanged or increased in all fetuses in group 3. Mortality rates in groups 1,2, and 3 were 1 of 12, 4 of 12 (difference not significant), and 5 of 7 (P < .05), respectively. CONCLUSION: Absence of normal decrease in amniotic fluid osmolality with gestation, in association with a high perinatal mortality rate, was found in severely but not in mildly hypoxemic fetuses with intrauterine growth restriction.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 703-710 |
| Number of pages | 8 |
| Journal | American Journal of Obstetrics and Gynecology |
| Volume | 180 |
| Issue number | 3 I |
| DOIs | |
| State | Published - 1999 |
| Externally published | Yes |
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Keywords
- Amniotic fluid
- Hypoxemia
- Intrauterine growth restriction
- Osmolality
- Sheep
ASJC Scopus subject areas
- Medicine(all)
- Obstetrics and Gynecology
Cite this
Amniotic fluid composition in the fetal lamb with intrauterine growth restriction. / Daniel, S. S.; Stark, R. I.; Tropper, P. J.; James, L. S.
In: American Journal of Obstetrics and Gynecology, Vol. 180, No. 3 I, 1999, p. 703-710.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Amniotic fluid composition in the fetal lamb with intrauterine growth restriction
AU - Daniel, S. S.
AU - Stark, R. I.
AU - Tropper, P. J.
AU - James, L. S.
PY - 1999
Y1 - 1999
N2 - OBJECTIVE: Our aim was to examine changes from normal in the composition of amniotic fluid in fetal lambs with mild and severe hypoxemia and intrauterine growth restriction. STUDY DESIGN: Pregnant sheep underwent maternal catheterization at 88 to 93 days' gestation and fetal catheterization at 105-112 days' gestation. Twelve pregnancies (group 1) provided control data (fetal PaO2 18-22 mm Hg), in 12 fetuses (group 2) mild hypoxemia (PaO2 16-19 mm Hg) was induced by prevention of the normal expansion of maternal blood volume, and in 7 fetuses (group 3) chronic hypoxemia (PaO2 12-18 mm Hg) developed spontaneously. RESULTS: In group 2 amniotic fluid osmolality and sodium concentrations were lower (approximately 30 mOsm/kg and 10 mEq/L, P < .05) and urea nitrogen level was higher (10 mg/dL, P < .05) than in group 1, in group 3 osmolality and sodium concentrations at approximately 120 days' gestation were similar to those in group 1. Whereas these values decreased with gestation n groups 1 and 2 (P < .05), they remained unchanged or increased in all fetuses in group 3. Mortality rates in groups 1,2, and 3 were 1 of 12, 4 of 12 (difference not significant), and 5 of 7 (P < .05), respectively. CONCLUSION: Absence of normal decrease in amniotic fluid osmolality with gestation, in association with a high perinatal mortality rate, was found in severely but not in mildly hypoxemic fetuses with intrauterine growth restriction.
AB - OBJECTIVE: Our aim was to examine changes from normal in the composition of amniotic fluid in fetal lambs with mild and severe hypoxemia and intrauterine growth restriction. STUDY DESIGN: Pregnant sheep underwent maternal catheterization at 88 to 93 days' gestation and fetal catheterization at 105-112 days' gestation. Twelve pregnancies (group 1) provided control data (fetal PaO2 18-22 mm Hg), in 12 fetuses (group 2) mild hypoxemia (PaO2 16-19 mm Hg) was induced by prevention of the normal expansion of maternal blood volume, and in 7 fetuses (group 3) chronic hypoxemia (PaO2 12-18 mm Hg) developed spontaneously. RESULTS: In group 2 amniotic fluid osmolality and sodium concentrations were lower (approximately 30 mOsm/kg and 10 mEq/L, P < .05) and urea nitrogen level was higher (10 mg/dL, P < .05) than in group 1, in group 3 osmolality and sodium concentrations at approximately 120 days' gestation were similar to those in group 1. Whereas these values decreased with gestation n groups 1 and 2 (P < .05), they remained unchanged or increased in all fetuses in group 3. Mortality rates in groups 1,2, and 3 were 1 of 12, 4 of 12 (difference not significant), and 5 of 7 (P < .05), respectively. CONCLUSION: Absence of normal decrease in amniotic fluid osmolality with gestation, in association with a high perinatal mortality rate, was found in severely but not in mildly hypoxemic fetuses with intrauterine growth restriction.
KW - Amniotic fluid
KW - Hypoxemia
KW - Intrauterine growth restriction
KW - Osmolality
KW - Sheep
UR - http://www.scopus.com/inward/record.url?scp=0032980223&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032980223&partnerID=8YFLogxK
U2 - 10.1016/S0002-9378(99)70276-0
DO - 10.1016/S0002-9378(99)70276-0
M3 - Article
VL - 180
SP - 703
EP - 710
JO - American Journal of Obstetrics and Gynecology
JF - American Journal of Obstetrics and Gynecology
SN - 0002-9378
IS - 3 I
ER -