On to the next round! A sensitive microarray of immobilized aminoglycosides was used to study the binding of antibiotics to resistance-causing enzymes (see picture). This, in combination with other methods, will lead to the identification of new antibiotics that bind weakly to these enzymes and strongly to the therapeutic targets.
- Antibiotics combinatorial chemistry
- Bioorganic chemistry
- High-throughput screening
ASJC Scopus subject areas