Aminoglycoside microarrays to study antibiotic resistance

Matthew D. Disney, Sophie Magnet, John S. Blanchard, Peter H. Seeberger

Research output: Contribution to journalArticle

50 Scopus citations

Abstract

On to the next round! A sensitive microarray of immobilized aminoglycosides was used to study the binding of antibiotics to resistance-causing enzymes (see picture). This, in combination with other methods, will lead to the identification of new antibiotics that bind weakly to these enzymes and strongly to the therapeutic targets.

Original languageEnglish (US)
Pages (from-to)1591-1594
Number of pages4
JournalAngewandte Chemie - International Edition
Volume43
Issue number12
DOIs
Publication statusPublished - Mar 12 2004

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Keywords

  • Antibiotics
  • Antibiotics combinatorial chemistry
  • Bioorganic chemistry
  • Carbohydrates
  • High-throughput screening

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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