Aminoglycoside microarrays to study antibiotic resistance

Matthew D. Disney; Sophie Magnet; John S. Blanchard; Peter H. Seeberger

doi:10.1002/anie.200353236

Aminoglycoside microarrays to study antibiotic resistance

Matthew D. Disney, Sophie Magnet, John S. Blanchard, Peter H. Seeberger

Biochemistry

Research output: Contribution to journal › Article › peer-review

55 Scopus citations

Abstract

On to the next round! A sensitive microarray of immobilized aminoglycosides was used to study the binding of antibiotics to resistance-causing enzymes (see picture). This, in combination with other methods, will lead to the identification of new antibiotics that bind weakly to these enzymes and strongly to the therapeutic targets.

Original language	English (US)
Pages (from-to)	1591-1594
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	43
Issue number	12
DOIs	https://doi.org/10.1002/anie.200353236
State	Published - Mar 12 2004

Keywords

Antibiotics
Antibiotics combinatorial chemistry
Bioorganic chemistry
Carbohydrates
High-throughput screening

ASJC Scopus subject areas

Catalysis
Chemistry(all)

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10.1002/anie.200353236

Cite this

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abstract = "On to the next round! A sensitive microarray of immobilized aminoglycosides was used to study the binding of antibiotics to resistance-causing enzymes (see picture). This, in combination with other methods, will lead to the identification of new antibiotics that bind weakly to these enzymes and strongly to the therapeutic targets.",

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AU - Magnet, Sophie

AU - Blanchard, John S.

AU - Seeberger, Peter H.

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KW - Antibiotics combinatorial chemistry

KW - Bioorganic chemistry

KW - Carbohydrates

KW - High-throughput screening

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Aminoglycoside microarrays to study antibiotic resistance

Abstract

Keywords

ASJC Scopus subject areas

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