American thyroid association guidelines for use of laboratory tests in thyroid disorders

Martin I. Surks, Inder J. Chopra, Cary N. Mariash, John T. Nicoloff, David H. Solomon, Leonard Wartofsky

Research output: Contribution to journalArticle

214 Citations (Scopus)

Abstract

Selection of appropriate laboratory determinations will enable the clinician to diagnose thyroid dysfunction readily in the majority of patients. At the present time, estimation of free thyroxine and a "sensitive" thyrotropin assay are recommended as the principal laboratory tests for thyroid disease. A decrease in serum free thyroxine estimate and a raised level of serum thyrotropin confirm the diagnosis of hypothyroidism caused by thyroid gland failure. An increase in free thyroxine estimate combined with a serum sensitive thyrotropin level suppressed to less than 0.1 mU/L establishes the diagnosis of thyrotoxicosis. In sick patients, a normal or raised serum free thyroxine estimate together with a normal level of serum thyrotropin suggests that the patient has neither hypothyroidism nor thyrotoxicosis. Patients with severe illnesses, generally in the intensive care unit, and those treated with certain drugs, as well as individuals with unusual thyroid disorders, may present with confusing laboratory findings. An understanding of the regulation of the thyroid hormone system and/or judicious consultation with an endocrinologist should enable the clinician to diagnose thyroid disease, if present, in such patients.

Original languageEnglish (US)
Pages (from-to)1529-1532
Number of pages4
JournalJournal of the American Medical Association
Volume263
Issue number11
StatePublished - Mar 16 1990

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Thyrotropin
Thyroid Gland
Thyroxine
Guidelines
Serum
Thyrotoxicosis
Thyroid Diseases
Hypothyroidism
Thyroid Hormones
Intensive Care Units
Referral and Consultation
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Surks, M. I., Chopra, I. J., Mariash, C. N., Nicoloff, J. T., Solomon, D. H., & Wartofsky, L. (1990). American thyroid association guidelines for use of laboratory tests in thyroid disorders. Journal of the American Medical Association, 263(11), 1529-1532.

American thyroid association guidelines for use of laboratory tests in thyroid disorders. / Surks, Martin I.; Chopra, Inder J.; Mariash, Cary N.; Nicoloff, John T.; Solomon, David H.; Wartofsky, Leonard.

In: Journal of the American Medical Association, Vol. 263, No. 11, 16.03.1990, p. 1529-1532.

Research output: Contribution to journalArticle

Surks, MI, Chopra, IJ, Mariash, CN, Nicoloff, JT, Solomon, DH & Wartofsky, L 1990, 'American thyroid association guidelines for use of laboratory tests in thyroid disorders', Journal of the American Medical Association, vol. 263, no. 11, pp. 1529-1532.
Surks MI, Chopra IJ, Mariash CN, Nicoloff JT, Solomon DH, Wartofsky L. American thyroid association guidelines for use of laboratory tests in thyroid disorders. Journal of the American Medical Association. 1990 Mar 16;263(11):1529-1532.
Surks, Martin I. ; Chopra, Inder J. ; Mariash, Cary N. ; Nicoloff, John T. ; Solomon, David H. ; Wartofsky, Leonard. / American thyroid association guidelines for use of laboratory tests in thyroid disorders. In: Journal of the American Medical Association. 1990 ; Vol. 263, No. 11. pp. 1529-1532.
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