American Society of Hematology living guidelines on the use of anticoagulation for thromboprophylaxis in patients with COVID-19: July 2021 update on postdischarge thromboprophylaxis

Adam Cuker, Eric K. Tseng, Robby Nieuwlaat, Pantep Angchaisuksiri, Clifton Blair, Kathryn Dane, Jennifer Davila, Maria T. DeSancho, David Diuguid, Daniel O. Griffin, Susan R. Kahn, Frederikus A. Klok, Alfred Ian Lee, Ignacio Neumann, Ashok Pai, Marc Righini, Kristen M. Sanfilippo, Deborah Siegal, Mike Skara, Deirdra R. TerrellKamshad Touri, Elie A. Akl, Reyad Nayif Al Jabiri, Yazan Nayif Al Jabiri, Angela M. Barbara, Antonio Bognanni, Imad Bou Akl, Mary Boulos, Romina Brignardello-Petersen, Rana Charide, Matthew Chan, Luis E. Colunga-Lozano, Karin Dearness, Andrea J. Darzi, Heba Hussein, Samer G. Karam, Philipp Kolb, Razan Mansour, Gian Paolo Morgano, Rami Z. Morsi, Giovanna Muti-Schunemann, Menatalla K. Nadim, Atefeh Noori, Binu A. Philip, Thomas Piggott, Yuan Qiu, Yetiani Roldan Benitez, Finn Schunemann, Adrienne Stevens, Karla Solo, Wojtek Wiercioch, Reem A. Mustafa, Holger J. Schunemann

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Background: COVID-19-related acute illness is associated with an increased risk of venous thromboembolism (VTE). Objective: These evidence-based guidelines of the American Society of Hematology (ASH) are intended to support patients, clinicians, and other health care professionals in decisions about the use of anticoagulation for thromboprophylaxis in patients with COVID-19 who do not have confirmed or suspected VTE. Methods: ASH formed a multidisciplinary guideline panel, including 3 patient representatives, and applied strategies to minimize potential bias from conflicts of interest. The McMaster University GRADE Centre supported the guideline development process, including performing systematic evidence reviews (up to March 2021). The panel prioritized clinical questions and outcomes according to their importance for clinicians and patients. The panel used the grading of recommendations assessment, development, and evaluation (GRADE) approach to assess evidence and make recommendations, which were subject to public comment. Results: The panel agreed on 1 additional recommendation. The panel issued a conditional recommendation against the use of outpatient anticoagulant prophylaxis in patients with COVID-19 who are discharged from the hospital and who do not have suspected or confirmed VTE or another indication for anticoagulation. Conclusions: This recommendation was based on very low certainty in the evidence, underscoring the need for high-quality randomized controlled trials assessing the role of postdischarge thromboprophylaxis. Other key research priorities include better evidence on assessing risk of thrombosis and bleeding outcomes in patients with COVID-19 after hospital discharge.

Original languageEnglish (US)
Pages (from-to)664-671
Number of pages8
JournalBlood Advances
Volume6
Issue number2
DOIs
StatePublished - Jan 25 2022

ASJC Scopus subject areas

  • Hematology

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