American Society of Clinical Oncology guideline for antiemetics in oncology: Update 2006

Mark G. Kris, Paul J. Hesketh, Mark R. Somerfield, Petra Feyer, Rebecca Clark-Snow, James M. Koeller, Gary R. Morrow, Lawrence W. Chinnery, Maurice J. Chesney, Richard J. Gralla, Steven M. Grunberg

Research output: Contribution to journalArticle

637 Citations (Scopus)

Abstract

Purpose: To update the 1999 American Society of Clinical Oncology guideline for antiemetics in oncology. Update Methodology: The Update Committee completed a review and analysis of data published from 1998 thru February 2006. The literature review focused on published randomized controlled trials, and systematic reviews and meta-analyses of published phase II and phase III randomized controlled trials. Recommendations: The three-drug combination of a 5-hydroxytryptamine-3 (5-HT3) serotonin receptor antagonist, dexamethasone, and aprepitant is recommended before chemotherapy of high emetic risk, For persons receiving chemotherapy of high emetic risk, there is no group of patients for whom agents of lower therapeutic index are appropriate first-choice antiemetics. These agents should be reserved for patients intolerant of or refractory to 5-HT3 serotonin receptor antagonists, neurokinin-1 receptor antagonists, and dexamethasone. The three-drug combination of a 5-HT3 receptor serotonin antagonist, dexamethasone, and aprepitant is recommended for patients receiving an anthracycline and cyclophosphamide. For patients receiving other chemotherapy of moderate emetic risk, the Update Committee continues to recommend the two-drug combination of a 5-HT3 receptor serotonin antagonist and dexamethasone. In all patients receiving cisplatin and all other agents of high emetic risk, the two-drug combination of dexamethasone and aprepitant is recommended for the prevention of delayed emesis. The Update Committee no longer recommends the combination of a 5-HT3 serotonin receptor antagonist and dexamethasone for the prevention of delayed emesis after chemotherapeutic agents of high emetic risk. Conclusion: The Update Committee recommends that clinicians administer antiemetics while considering patients' emetic risk categories and other characteristics.

Original languageEnglish (US)
Pages (from-to)2932-2947
Number of pages16
JournalJournal of Clinical Oncology
Volume24
Issue number18
DOIs
StatePublished - Jun 20 2006
Externally publishedYes

Fingerprint

Emetics
Antiemetics
Receptors, Serotonin, 5-HT3
aprepitant
Serotonin Antagonists
Dexamethasone
Guidelines
Drug Combinations
Drug Therapy
Vomiting
Randomized Controlled Trials
Neurokinin-1 Receptor Antagonists
Anthracyclines
Proxy
Cyclophosphamide
Cisplatin
Meta-Analysis

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Kris, M. G., Hesketh, P. J., Somerfield, M. R., Feyer, P., Clark-Snow, R., Koeller, J. M., ... Grunberg, S. M. (2006). American Society of Clinical Oncology guideline for antiemetics in oncology: Update 2006. Journal of Clinical Oncology, 24(18), 2932-2947. https://doi.org/10.1200/JCO.2006.06.9591

American Society of Clinical Oncology guideline for antiemetics in oncology : Update 2006. / Kris, Mark G.; Hesketh, Paul J.; Somerfield, Mark R.; Feyer, Petra; Clark-Snow, Rebecca; Koeller, James M.; Morrow, Gary R.; Chinnery, Lawrence W.; Chesney, Maurice J.; Gralla, Richard J.; Grunberg, Steven M.

In: Journal of Clinical Oncology, Vol. 24, No. 18, 20.06.2006, p. 2932-2947.

Research output: Contribution to journalArticle

Kris, MG, Hesketh, PJ, Somerfield, MR, Feyer, P, Clark-Snow, R, Koeller, JM, Morrow, GR, Chinnery, LW, Chesney, MJ, Gralla, RJ & Grunberg, SM 2006, 'American Society of Clinical Oncology guideline for antiemetics in oncology: Update 2006', Journal of Clinical Oncology, vol. 24, no. 18, pp. 2932-2947. https://doi.org/10.1200/JCO.2006.06.9591
Kris MG, Hesketh PJ, Somerfield MR, Feyer P, Clark-Snow R, Koeller JM et al. American Society of Clinical Oncology guideline for antiemetics in oncology: Update 2006. Journal of Clinical Oncology. 2006 Jun 20;24(18):2932-2947. https://doi.org/10.1200/JCO.2006.06.9591
Kris, Mark G. ; Hesketh, Paul J. ; Somerfield, Mark R. ; Feyer, Petra ; Clark-Snow, Rebecca ; Koeller, James M. ; Morrow, Gary R. ; Chinnery, Lawrence W. ; Chesney, Maurice J. ; Gralla, Richard J. ; Grunberg, Steven M. / American Society of Clinical Oncology guideline for antiemetics in oncology : Update 2006. In: Journal of Clinical Oncology. 2006 ; Vol. 24, No. 18. pp. 2932-2947.
@article{d27db21213e54e02b7c5fd5a3ab6fee1,
title = "American Society of Clinical Oncology guideline for antiemetics in oncology: Update 2006",
abstract = "Purpose: To update the 1999 American Society of Clinical Oncology guideline for antiemetics in oncology. Update Methodology: The Update Committee completed a review and analysis of data published from 1998 thru February 2006. The literature review focused on published randomized controlled trials, and systematic reviews and meta-analyses of published phase II and phase III randomized controlled trials. Recommendations: The three-drug combination of a 5-hydroxytryptamine-3 (5-HT3) serotonin receptor antagonist, dexamethasone, and aprepitant is recommended before chemotherapy of high emetic risk, For persons receiving chemotherapy of high emetic risk, there is no group of patients for whom agents of lower therapeutic index are appropriate first-choice antiemetics. These agents should be reserved for patients intolerant of or refractory to 5-HT3 serotonin receptor antagonists, neurokinin-1 receptor antagonists, and dexamethasone. The three-drug combination of a 5-HT3 receptor serotonin antagonist, dexamethasone, and aprepitant is recommended for patients receiving an anthracycline and cyclophosphamide. For patients receiving other chemotherapy of moderate emetic risk, the Update Committee continues to recommend the two-drug combination of a 5-HT3 receptor serotonin antagonist and dexamethasone. In all patients receiving cisplatin and all other agents of high emetic risk, the two-drug combination of dexamethasone and aprepitant is recommended for the prevention of delayed emesis. The Update Committee no longer recommends the combination of a 5-HT3 serotonin receptor antagonist and dexamethasone for the prevention of delayed emesis after chemotherapeutic agents of high emetic risk. Conclusion: The Update Committee recommends that clinicians administer antiemetics while considering patients' emetic risk categories and other characteristics.",
author = "Kris, {Mark G.} and Hesketh, {Paul J.} and Somerfield, {Mark R.} and Petra Feyer and Rebecca Clark-Snow and Koeller, {James M.} and Morrow, {Gary R.} and Chinnery, {Lawrence W.} and Chesney, {Maurice J.} and Gralla, {Richard J.} and Grunberg, {Steven M.}",
year = "2006",
month = "6",
day = "20",
doi = "10.1200/JCO.2006.06.9591",
language = "English (US)",
volume = "24",
pages = "2932--2947",
journal = "Journal of Clinical Oncology",
issn = "0732-183X",
publisher = "American Society of Clinical Oncology",
number = "18",

}

TY - JOUR

T1 - American Society of Clinical Oncology guideline for antiemetics in oncology

T2 - Update 2006

AU - Kris, Mark G.

AU - Hesketh, Paul J.

AU - Somerfield, Mark R.

AU - Feyer, Petra

AU - Clark-Snow, Rebecca

AU - Koeller, James M.

AU - Morrow, Gary R.

AU - Chinnery, Lawrence W.

AU - Chesney, Maurice J.

AU - Gralla, Richard J.

AU - Grunberg, Steven M.

PY - 2006/6/20

Y1 - 2006/6/20

N2 - Purpose: To update the 1999 American Society of Clinical Oncology guideline for antiemetics in oncology. Update Methodology: The Update Committee completed a review and analysis of data published from 1998 thru February 2006. The literature review focused on published randomized controlled trials, and systematic reviews and meta-analyses of published phase II and phase III randomized controlled trials. Recommendations: The three-drug combination of a 5-hydroxytryptamine-3 (5-HT3) serotonin receptor antagonist, dexamethasone, and aprepitant is recommended before chemotherapy of high emetic risk, For persons receiving chemotherapy of high emetic risk, there is no group of patients for whom agents of lower therapeutic index are appropriate first-choice antiemetics. These agents should be reserved for patients intolerant of or refractory to 5-HT3 serotonin receptor antagonists, neurokinin-1 receptor antagonists, and dexamethasone. The three-drug combination of a 5-HT3 receptor serotonin antagonist, dexamethasone, and aprepitant is recommended for patients receiving an anthracycline and cyclophosphamide. For patients receiving other chemotherapy of moderate emetic risk, the Update Committee continues to recommend the two-drug combination of a 5-HT3 receptor serotonin antagonist and dexamethasone. In all patients receiving cisplatin and all other agents of high emetic risk, the two-drug combination of dexamethasone and aprepitant is recommended for the prevention of delayed emesis. The Update Committee no longer recommends the combination of a 5-HT3 serotonin receptor antagonist and dexamethasone for the prevention of delayed emesis after chemotherapeutic agents of high emetic risk. Conclusion: The Update Committee recommends that clinicians administer antiemetics while considering patients' emetic risk categories and other characteristics.

AB - Purpose: To update the 1999 American Society of Clinical Oncology guideline for antiemetics in oncology. Update Methodology: The Update Committee completed a review and analysis of data published from 1998 thru February 2006. The literature review focused on published randomized controlled trials, and systematic reviews and meta-analyses of published phase II and phase III randomized controlled trials. Recommendations: The three-drug combination of a 5-hydroxytryptamine-3 (5-HT3) serotonin receptor antagonist, dexamethasone, and aprepitant is recommended before chemotherapy of high emetic risk, For persons receiving chemotherapy of high emetic risk, there is no group of patients for whom agents of lower therapeutic index are appropriate first-choice antiemetics. These agents should be reserved for patients intolerant of or refractory to 5-HT3 serotonin receptor antagonists, neurokinin-1 receptor antagonists, and dexamethasone. The three-drug combination of a 5-HT3 receptor serotonin antagonist, dexamethasone, and aprepitant is recommended for patients receiving an anthracycline and cyclophosphamide. For patients receiving other chemotherapy of moderate emetic risk, the Update Committee continues to recommend the two-drug combination of a 5-HT3 receptor serotonin antagonist and dexamethasone. In all patients receiving cisplatin and all other agents of high emetic risk, the two-drug combination of dexamethasone and aprepitant is recommended for the prevention of delayed emesis. The Update Committee no longer recommends the combination of a 5-HT3 serotonin receptor antagonist and dexamethasone for the prevention of delayed emesis after chemotherapeutic agents of high emetic risk. Conclusion: The Update Committee recommends that clinicians administer antiemetics while considering patients' emetic risk categories and other characteristics.

UR - http://www.scopus.com/inward/record.url?scp=33745515076&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33745515076&partnerID=8YFLogxK

U2 - 10.1200/JCO.2006.06.9591

DO - 10.1200/JCO.2006.06.9591

M3 - Article

C2 - 16717289

AN - SCOPUS:33745515076

VL - 24

SP - 2932

EP - 2947

JO - Journal of Clinical Oncology

JF - Journal of Clinical Oncology

SN - 0732-183X

IS - 18

ER -