Amelioration of radiation-induced liver damage in partially hepatectomized rats by hepatocyte transplantation

Chandan Guha, Anand Sharma, Sanjeev Gupta, Alan Alfieri, Giridhar R. Gorla, Singh Gagandeep, Rana Sokhi, Namita Roy-Chowdhury, Kathryn E. Tanaka, Bhadrasain Vikram, Jayanta Roy-Chowdhury

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150 Citations (Scopus)

Abstract

Hepatic tumors often recur in the liver after surgical resection. Postoperative radiotherapy (RT) could improve survival, but curative RT may induce delayed life-threatening radiation-induced liver damage. Because RT inhibits liver regeneration, we hypothesized that unirradiated, transplanted hepatocytes would proliferate preferentially in a partially resected and irradiated liver, providing metabolic support. We subjected F344 rats to hepatic RT and partial hepatectomy with/without a single intrasplenic, syngeneic hepatocyte transplantation. Hepatocyte transplantation ameliorated radiation-induced liver damage and improved survival of rats receiving RT after partial hepatectomy. We further demonstrated that transplanted hepatocytes extensively repopulate and function in a heavily irradiated rat liver.

Original languageEnglish (US)
Pages (from-to)5871-5874
Number of pages4
JournalCancer Research
Volume59
Issue number23
StatePublished - Dec 1 1999

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Hepatocytes
Transplantation
Radiation
Liver
Radiotherapy
Hepatectomy
Isogeneic Transplantation
Liver Regeneration
Inbred F344 Rats
Neoplasms

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Amelioration of radiation-induced liver damage in partially hepatectomized rats by hepatocyte transplantation. / Guha, Chandan; Sharma, Anand; Gupta, Sanjeev; Alfieri, Alan; Gorla, Giridhar R.; Gagandeep, Singh; Sokhi, Rana; Roy-Chowdhury, Namita; Tanaka, Kathryn E.; Vikram, Bhadrasain; Roy-Chowdhury, Jayanta.

In: Cancer Research, Vol. 59, No. 23, 01.12.1999, p. 5871-5874.

Research output: Contribution to journalArticle

Guha, C, Sharma, A, Gupta, S, Alfieri, A, Gorla, GR, Gagandeep, S, Sokhi, R, Roy-Chowdhury, N, Tanaka, KE, Vikram, B & Roy-Chowdhury, J 1999, 'Amelioration of radiation-induced liver damage in partially hepatectomized rats by hepatocyte transplantation', Cancer Research, vol. 59, no. 23, pp. 5871-5874.
Guha, Chandan ; Sharma, Anand ; Gupta, Sanjeev ; Alfieri, Alan ; Gorla, Giridhar R. ; Gagandeep, Singh ; Sokhi, Rana ; Roy-Chowdhury, Namita ; Tanaka, Kathryn E. ; Vikram, Bhadrasain ; Roy-Chowdhury, Jayanta. / Amelioration of radiation-induced liver damage in partially hepatectomized rats by hepatocyte transplantation. In: Cancer Research. 1999 ; Vol. 59, No. 23. pp. 5871-5874.
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AU - Sokhi, Rana

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