Amelioration of radiation-induced liver damage in partially hepatectomized rats by hepatocyte transplantation

Chandan Guha, Anand Sharma, Sanjeev Gupta, Alan Alfieri, Giridhar R. Gorla, Singh Gagandeep, Rana Sokhi, Namita Roy-Chowdhury, Kathryn E. Tanaka, Bhadrasain Vikram, Jayanta Roy-Chowdhury

Research output: Contribution to journalArticle

152 Scopus citations

Abstract

Hepatic tumors often recur in the liver after surgical resection. Postoperative radiotherapy (RT) could improve survival, but curative RT may induce delayed life-threatening radiation-induced liver damage. Because RT inhibits liver regeneration, we hypothesized that unirradiated, transplanted hepatocytes would proliferate preferentially in a partially resected and irradiated liver, providing metabolic support. We subjected F344 rats to hepatic RT and partial hepatectomy with/without a single intrasplenic, syngeneic hepatocyte transplantation. Hepatocyte transplantation ameliorated radiation-induced liver damage and improved survival of rats receiving RT after partial hepatectomy. We further demonstrated that transplanted hepatocytes extensively repopulate and function in a heavily irradiated rat liver.

Original languageEnglish (US)
Pages (from-to)5871-5874
Number of pages4
JournalCancer Research
Volume59
Issue number23
StatePublished - Dec 1 1999

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Guha, C., Sharma, A., Gupta, S., Alfieri, A., Gorla, G. R., Gagandeep, S., Sokhi, R., Roy-Chowdhury, N., Tanaka, K. E., Vikram, B., & Roy-Chowdhury, J. (1999). Amelioration of radiation-induced liver damage in partially hepatectomized rats by hepatocyte transplantation. Cancer Research, 59(23), 5871-5874.