Amelioration of radiation-induced liver damage in partially hepatectomized rats by hepatocyte transplantation

Chandan Guha; Anand Sharma; Sanjeev Gupta; Alan Alfieri; Giridhar R. Gorla; Singh Gagandeep; Rana Sokhi; Namita Roy-Chowdhury; Kathryn E. Tanaka; Bhadrasain Vikram; Jayanta Roy-Chowdhury

Amelioration of radiation-induced liver damage in partially hepatectomized rats by hepatocyte transplantation

Chandan Guha, Anand Sharma, Sanjeev Gupta, Alan Alfieri, Giridhar R. Gorla, Singh Gagandeep, Rana Sokhi, Namita Roy-Chowdhury, Kathryn E. Tanaka, Bhadrasain Vikram, Jayanta Roy-Chowdhury

Research output: Contribution to journal › Article › peer-review

166 Scopus citations

Abstract

Hepatic tumors often recur in the liver after surgical resection. Postoperative radiotherapy (RT) could improve survival, but curative RT may induce delayed life-threatening radiation-induced liver damage. Because RT inhibits liver regeneration, we hypothesized that unirradiated, transplanted hepatocytes would proliferate preferentially in a partially resected and irradiated liver, providing metabolic support. We subjected F344 rats to hepatic RT and partial hepatectomy with/without a single intrasplenic, syngeneic hepatocyte transplantation. Hepatocyte transplantation ameliorated radiation-induced liver damage and improved survival of rats receiving RT after partial hepatectomy. We further demonstrated that transplanted hepatocytes extensively repopulate and function in a heavily irradiated rat liver.

Original language	English (US)
Pages (from-to)	5871-5874
Number of pages	4
Journal	Cancer research
Volume	59
Issue number	23
State	Published - Dec 1 1999

ASJC Scopus subject areas

Oncology
Cancer Research

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Cite this

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title = "Amelioration of radiation-induced liver damage in partially hepatectomized rats by hepatocyte transplantation",

abstract = "Hepatic tumors often recur in the liver after surgical resection. Postoperative radiotherapy (RT) could improve survival, but curative RT may induce delayed life-threatening radiation-induced liver damage. Because RT inhibits liver regeneration, we hypothesized that unirradiated, transplanted hepatocytes would proliferate preferentially in a partially resected and irradiated liver, providing metabolic support. We subjected F344 rats to hepatic RT and partial hepatectomy with/without a single intrasplenic, syngeneic hepatocyte transplantation. Hepatocyte transplantation ameliorated radiation-induced liver damage and improved survival of rats receiving RT after partial hepatectomy. We further demonstrated that transplanted hepatocytes extensively repopulate and function in a heavily irradiated rat liver.",

author = "Chandan Guha and Anand Sharma and Sanjeev Gupta and Alan Alfieri and Gorla, {Giridhar R.} and Singh Gagandeep and Rana Sokhi and Namita Roy-Chowdhury and Tanaka, {Kathryn E.} and Bhadrasain Vikram and Jayanta Roy-Chowdhury",

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T1 - Amelioration of radiation-induced liver damage in partially hepatectomized rats by hepatocyte transplantation

AU - Guha, Chandan

AU - Sharma, Anand

AU - Gupta, Sanjeev

AU - Alfieri, Alan

AU - Gorla, Giridhar R.

AU - Gagandeep, Singh

AU - Sokhi, Rana

AU - Roy-Chowdhury, Namita

AU - Tanaka, Kathryn E.

AU - Vikram, Bhadrasain

AU - Roy-Chowdhury, Jayanta

PY - 1999/12/1

Y1 - 1999/12/1

N2 - Hepatic tumors often recur in the liver after surgical resection. Postoperative radiotherapy (RT) could improve survival, but curative RT may induce delayed life-threatening radiation-induced liver damage. Because RT inhibits liver regeneration, we hypothesized that unirradiated, transplanted hepatocytes would proliferate preferentially in a partially resected and irradiated liver, providing metabolic support. We subjected F344 rats to hepatic RT and partial hepatectomy with/without a single intrasplenic, syngeneic hepatocyte transplantation. Hepatocyte transplantation ameliorated radiation-induced liver damage and improved survival of rats receiving RT after partial hepatectomy. We further demonstrated that transplanted hepatocytes extensively repopulate and function in a heavily irradiated rat liver.

AB - Hepatic tumors often recur in the liver after surgical resection. Postoperative radiotherapy (RT) could improve survival, but curative RT may induce delayed life-threatening radiation-induced liver damage. Because RT inhibits liver regeneration, we hypothesized that unirradiated, transplanted hepatocytes would proliferate preferentially in a partially resected and irradiated liver, providing metabolic support. We subjected F344 rats to hepatic RT and partial hepatectomy with/without a single intrasplenic, syngeneic hepatocyte transplantation. Hepatocyte transplantation ameliorated radiation-induced liver damage and improved survival of rats receiving RT after partial hepatectomy. We further demonstrated that transplanted hepatocytes extensively repopulate and function in a heavily irradiated rat liver.

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ER -

Amelioration of radiation-induced liver damage in partially hepatectomized rats by hepatocyte transplantation

Abstract

ASJC Scopus subject areas

UN SDGs

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