Amelioration of experimental glomerulonephritis by dietary protein restriction

Joel Neugarten, H. D. Feiner, R. G. Schacht, D. S. Baldwin

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

We have examined the effects of various levels of dietary protein intake on the course of nephrotic serum nephritis in the rat by feeding low (4.6% casein), standard (23% casein), and high (57.5% casein) protein diets which were identical in calorie, mineral, and electrolyte content. Nephritic rats on a high protein diet mainfested heavy proteinuremia, hypoalbuminia, hypercholesterolemia, azotemia, and elevated serum creatinine levels. In those subjected to dietary protein restriction, proteinuria remitted and azotemia did not develop. While mesangial widening, interstitial abnormalities, and segmental proliferation and sclerosis of glomeruli occurred regularly in nephritic rats fed high protein diets, histologic abnormalities were virtually absent in those on low protein intake. Animals on a standard protein intake manifested histologic and clinical features intermediate in severity. We conclude that the renal functional and histologic consequences of nephrotoxic serum nephritis can be averted by dietary protein restriction.

Original languageEnglish (US)
Pages (from-to)595-601
Number of pages7
JournalKidney International
Volume24
Issue number5
StatePublished - 1983
Externally publishedYes

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Dietary Proteins
Glomerulonephritis
Caseins
Azotemia
Nephritis
Diet
Proteins
Kidney
Serum
Sclerosis
Hypercholesterolemia
Proteinuria
Electrolytes
Minerals
Creatinine

ASJC Scopus subject areas

  • Nephrology

Cite this

Neugarten, J., Feiner, H. D., Schacht, R. G., & Baldwin, D. S. (1983). Amelioration of experimental glomerulonephritis by dietary protein restriction. Kidney International, 24(5), 595-601.

Amelioration of experimental glomerulonephritis by dietary protein restriction. / Neugarten, Joel; Feiner, H. D.; Schacht, R. G.; Baldwin, D. S.

In: Kidney International, Vol. 24, No. 5, 1983, p. 595-601.

Research output: Contribution to journalArticle

Neugarten, J, Feiner, HD, Schacht, RG & Baldwin, DS 1983, 'Amelioration of experimental glomerulonephritis by dietary protein restriction', Kidney International, vol. 24, no. 5, pp. 595-601.
Neugarten, Joel ; Feiner, H. D. ; Schacht, R. G. ; Baldwin, D. S. / Amelioration of experimental glomerulonephritis by dietary protein restriction. In: Kidney International. 1983 ; Vol. 24, No. 5. pp. 595-601.
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