TY - JOUR
T1 - Alzheimer's disease
T2 - A healthcare burden of epidemic proportion
AU - Dharmarajan, T. S.
AU - Gunturu, Srinivas G.
PY - 2009
Y1 - 2009
N2 - Alzheimer's disease is the most common cause of dementia and increases in prevalence exponentially with age, with trends in the United States likely to worsen in ensuing decades. The pathology in Alzheimer's disease is characterized by an increase in extracellular amyloid plaques and intraneural neurofibrillary tangles, with neuronal destruction in several areas of the brain, and biochemically by a deficiency in acetylcholine; clinical manifestations include progressive loss of memory, change in personality, and behavioral disturbances. Pharmacotherapy includes the use of cholinesterase inhibitors and memantine; addressing the many behavioral manifestations of the disease, especially in advanced stages, imposes tremendous burden to caregivers and healthcare resources.
AB - Alzheimer's disease is the most common cause of dementia and increases in prevalence exponentially with age, with trends in the United States likely to worsen in ensuing decades. The pathology in Alzheimer's disease is characterized by an increase in extracellular amyloid plaques and intraneural neurofibrillary tangles, with neuronal destruction in several areas of the brain, and biochemically by a deficiency in acetylcholine; clinical manifestations include progressive loss of memory, change in personality, and behavioral disturbances. Pharmacotherapy includes the use of cholinesterase inhibitors and memantine; addressing the many behavioral manifestations of the disease, especially in advanced stages, imposes tremendous burden to caregivers and healthcare resources.
UR - http://www.scopus.com/inward/record.url?scp=77953429975&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77953429975&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:77953429975
SN - 1942-2962
VL - 2
SP - 39
EP - 47
JO - American Health and Drug Benefits
JF - American Health and Drug Benefits
IS - 1
ER -
